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521.
Bo Jin Ph.D. Bo Yi B.A. Qingtao Wei M.D. Linchuan Liao Ph.D. 《Journal of forensic sciences》2019,64(3):941-945
Paraquat poisoning usually results from suicide, occupational, or accidental exposure. Herein, we report a rare fatal case of homicidal paraquat poisoning. A 58‐year‐old man was poisoned by taking paraquat‐mixed medicine and wearing paraquat‐soaked underwear. In the absence of a history of paraquat exposure, the patient was misdiagnosed with pulmonary infection and scrotal dermatitis and died of respiratory failure 24 days after the initial exposure to paraquat. Ultra‐performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) was applied to detect and quantify paraquat in postmortem specimens. The concentration of paraquat in postmortem specimens from high to low is lung (0.49 μg/g), brain (0.32 μg/g), kidney (0.24 μg/g), liver (0.20 μg/g), cardiac blood (0.11 μg/mL), and stomach wall (<LOQ). Identification of homicidal paraquat poisoning is not easy for a clinician or a forensic pathologist, it is important to consider the possibility of paraquat poisoning when patients suffer from rapidly aggravating pneumonia of unknown origin. 相似文献
522.
Marilou Caron‐Cantin B.Sc. Marcia Abbott M.D. Elizabeth Brooks‐Lim M.D. Bamidele Adeagbo M.D. 《Journal of forensic sciences》2018,63(5):1573-1576
Thromboembolic events in the context of carbon monoxide (CO) exposure have been well described in the literature. Six cases of clinically significant coronary thrombosis following CO exposure were previously reported. However, factors affecting the development of coronary thrombus in CO exposure are poorly understood, and the significance of this finding in a forensic context is not clear. This article discusses a case of coronary thrombosis found at autopsy following a death in which CO poisoning was suspected. A 67‐year‐old man was found dead in his garage with four vehicles with their ignition in the “on” position and their tanks empty. At autopsy, severe coronary atherosclerosis and an acute nonocclusive coronary thrombus were found. Given the dissimilarities among cases and the presence of CO exposure, it was suggested that the coronary artery thrombosis is likely due to the inherent prothrombotic mechanism of CO, the only common denominator in all the cases. 相似文献
523.
"适度进口"是在公平国际贸易体制下,基于国内粮食供需平衡合理进口的农业可持续发展策略。受"新自由主义"、有限农业资源与GDP主义等因素的影响,特别是"基因革命","过度"的粮食进口将进一步加剧粮食市场结构性矛盾、农业环境与生命健康的潜在风险以及粮食主权的安全。为此,应以独立平等的立法权、"双反"的司法救济权与农业"特殊保障机制"的自卫权维护粮食主权;以完善农业政策立法调整粮食产业结构,使粮食供需与生态平衡,限制和禁止转基因粮食进口,构建"适度进口"策略的法律框架,确保粮食安全。 相似文献
524.
在我国出口贸易中 ,出口食品“通行证”( HACCP—食品安全卫生预防体系 )具有十分重要的位置。文章对 HACCP的应用状况进行分析 ,提出了在我国全面推行 HACCP体系的举措 ,并提出了完善立法的仪 相似文献
525.
526.
毒鼠强中毒实质性器官组织超微病理变化研究 总被引:4,自引:0,他引:4
目的观察不同浓度毒鼠强中毒大鼠实质性器官的超微病理变化。方法采用灌胃方法使大鼠毒鼠强染毒,制作大鼠中毒模型,并以健康大鼠灌服生理盐水为对照,提取大鼠的脑皮质、脑干桥脑部、心、肝、脾、肾等实质性器官,进行超微病理观察。结果不同浓度的毒鼠强可对心肌细胞、脑神经细胞、神经纤维和肝细胞造成一定损伤,而对肾、脾组织细胞损伤不明显。脑皮质神经元细胞结构模糊,内质网轻度扩张,线粒体扩张水肿,且无明显的剂量-反应关系;脑干桥脑部可见多处弥散性软化灶,神经细胞核溶解,神经纤维细胞有坏死,血管内皮细胞肿胀,血管周围有间隙出现,脑干损伤有明显的剂量-反应关系;心肌细胞表现为不同程度的心肌细胞坏死、线粒体弥漫性崩解或肿胀、肌丝断裂溶解、肌溶灶普遍存在等变化,并呈现出明显的剂量-效应关系;肝细胞表现弥漫性肿胀,细胞模糊,肝窦狭小,内皮细胞肿胀,结构模糊不清,细胞质内线粒体明显肿胀,糖原含量减少,与中毒剂量和时间均呈明显相关性。结论脑、心、肝可能为其毒性作用的主要靶器官或靶组织。 相似文献
527.
528.
作者通过大鼠乌头碱中毒心肌线粒体 CCO 的超微结构定位,观察到乌头碱引起 CCO 的定位紊乱。由于损害程度不同,出现三种情况:(1)CCO 失去在线粒体嵴膜和内膜上的定位,酶反应产物呈自由扩散状态,酶反应强度对照组有所增强或相似;(2)CCO 失去在线粒体嵴膜和内膜上的定位,酶反应强度较对照组明显减弱;(3)在同一线粒体中部分保持 CCO 的嵴膜、内膜定位,部分失去 CCO 在嵴膜和内膜上的定位。实验结果表明,乌头碱干扰了心肌细胞呼吸链的电子传递,抑制氧化磷酸化的正常进行,导致心肌能量代谢障碍。 相似文献
529.
The influence of external organizations and pressures on business risk management practices has hitherto been examined through the influence of state regulatory regimes on businesses. This article concentrates on key socio‐legal concerns about the influence of the law in social and economic life. We know that the sources of regulation and risk management are diversifying beyond the state. What we do not have is much empirically informed research about the range of sources influencing the business world and in particular the weighting of influence exercised by them. In this paper we explore the understandings regulatory actors have of the different external pressures on business risk management through an empirical study of the understandings of those in the food retail sector about the management of food safety and food hygiene risks. A broader objective is to throw some further light onto the debate about regulation within and beyond the state. 相似文献
530.
Globus Pallidus Necrosis Unrelated to Carbon Monoxide Poisoning: Retrospective Analysis of 27 Cases of Basal Ganglia Necrosis
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Nicole A. Yarid M.D. Richard C. Harruff M.D. Ph.D. 《Journal of forensic sciences》2015,60(6):1484-1487
Bilateral globus pallidus necrosis is said to be characteristic of carbon monoxide (CO) poisoning. However, there has been no scientific test of this hypothesis. To examine the assertion that globus pallidus necrosis is typical of CO poisoning, this study examined autopsy cases from the King County Medical Examiner's Office (KCMEO) between 1994 and 2013. Twenty-seven cases with bilateral basal ganglia lesions were identified and examined for associated or causative disease or injury with the following results: 10 cases of drug overdose, seven heart disease, three asphyxia, two chronic ethanolism, two Huntington-like disorder, and one case each of remote trauma, rheumatic heart disease, and cerebral artery gas embolism. Additionally, review of all known cases at KCMEO of CO poisoning found no evidence of globus pallidus or basal ganglia necrosis. Thus, this study provides no support for the assertion that globus pallidus necrosis is characteristic of CO poisoning. 相似文献