全文获取类型
收费全文 | 409篇 |
免费 | 5篇 |
专业分类
工人农民 | 3篇 |
外交国际关系 | 31篇 |
法律 | 366篇 |
中国政治 | 1篇 |
政治理论 | 1篇 |
综合类 | 12篇 |
出版年
2023年 | 1篇 |
2022年 | 11篇 |
2021年 | 6篇 |
2020年 | 11篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 16篇 |
2016年 | 18篇 |
2015年 | 14篇 |
2014年 | 33篇 |
2013年 | 27篇 |
2012年 | 19篇 |
2011年 | 29篇 |
2010年 | 21篇 |
2009年 | 15篇 |
2008年 | 25篇 |
2007年 | 21篇 |
2006年 | 21篇 |
2005年 | 25篇 |
2004年 | 21篇 |
2003年 | 15篇 |
2002年 | 18篇 |
2001年 | 12篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1984年 | 1篇 |
排序方式: 共有414条查询结果,搜索用时 15 毫秒
321.
Alessio Coletti Sara Merigioli Simona Severini Massimo Lancia Susanna Massetti Fabio Suadoni Eugenia Carnevali 《Forensic Science International: Genetics Supplement Series》2009,2(1):202-203
A case of a woman killed in Perugia is reported. The woman was beaten to death and the body showed evidence of bites, kicks and punches. The request of the Court was to verify the presence of bites and if they belonged to humans. Morphological examination and genetic analysis with human Y-specific markers were performed in order to verify the origin of the bites. The DNA profile from the surrounded area of the traces was compared with the profile of the victim's husband (the suspect).The results showed a match between the profile of the suspect and that of the traces for all loci examined. Due to the fact that also other relatives of the husband's male lineage lived in the same house, it was not possible to identify the man who really contributed to the traces. Therefore, the analysis was implemented with autosomal STR markers, which showed a mixed genetic profile. In order to verify the number and the identity of the contributors, statistical analysis based upon peak area information was performed with Probabilistic Expert Systems. 相似文献
322.
323.
目的Y染色体为男性所特有,其遗传标记蕴含着丰富的生物地理信息,故可溯源家系,在嫌疑人排查和追踪中发挥作用。Y-STR突变率较高,而Y-SNP突变率极低,几乎不会发生回复突变,所以后代男性群体携带祖先特有的Y-SNP。本研究期望通过现在我国Y库建设中通用的17个Y-STR的单倍型数据预测Y-SNP单倍群细支。方法基于前期观察,选取千人基因组计划III期中的513例东亚人群(中国及周边区域)作为基础数据集,在Java平台和Microsoft Excel软件框架下,以遗传距离计算和Y染色体进化树构建手段相联合研发Y-STR数据的家系特异性单倍群归属判别分析软件:EA-YPredictor。结果本研究揭示了15个单倍群大支下的核心单倍型。通过随机选取70个公开数据库样本,EA-YPredictor软件预测准确性达到92.8%(95%置信区间:[84.1%,97.6%])。结论在Y-SNP复合扩增检测尚无定论的情况下,本软件可基于二代测序样本对Y-STR数据库样本进行单倍群细支的准确预测,能适用于辅助家系单倍群判断。随着测序技术的不断换代和优化,更多高通量的Y-STR和Y-SNP数据补充将会使本软件进一步优化。此外,本软件对于Y数据库中Y-SNP遗传标记的筛查建库有一定指向作用。 相似文献
324.
325.
326.
We analyzed the accumulation of population polymorphism in 2504 individuals - nuclear genomes (nDNA) of 26 populations (81 genes associated to extreme environments) and 3295 mitochondrial genomes (mtDNA) of 47 populations with the aim to found mitonuclear relationship associated an extremes environment as altitude. For that, we use an algorithm developed by us to determine the accumulation of polymorphisms by segments in the genome and thus be able to perform the multivariate analysis to found SNPs differences and similarities among populations. The results showed in Peruvian population a statistically significant mitonuclear relationship for 113/293970 nDNA SNPs in 16/81 genes. In the case of the mtDNA, we found a statistically significant mitonuclear relationship for 6/22 mtDNA positions – Gene. Additionally for the Peruvian population, the MRPP3 had the greatest polymorphism contribution with respect to other populations. Then, these nDNA and mtDNA SNPs in genetically close populations to Peru can be applied to forensic genomic phenotyping to identify groups likely adapted to extreme conditions (such as altitude) or make individualization between low and high altitude populations. 相似文献
327.
《Forensic Science International: Genetics Supplement Series》2019,7(1):189-190
The Investigator DIPplex® kit (Qiagen) contains components for the simultaneous amplification and analysis of 30 biallelic autosomal InDels and amelogenin. The objective of this study was to estimate the diversity of the 30 markers in a Polish population sample (N = 389) and to evaluate their usefulness in forensic genetics. The DIPplex genotype distributions showed no significant deviation from Hardy-Weinberg rule expectations (Bonferroni corrected). The mean observed heterozygosity value is 0.4611, and the combined Matching Probability value is 1.08x10−13. The investigated marker set has been confirmed as a potential extension to standard STR - based kits or a separate informative system for individual identification and kinship analysis. 相似文献
328.
The presence of more than one DNA contributor in an evidentiary sample may preclude attempts to use forensic genetic genealogy to develop an investigative lead. To address this issue, we developed a workflow for deconvolution of SNP mixtures into single source profiles that are suitable for matching against a genealogical database. Using the method, two-contributor DNA mixtures assayed using a commercial SNP typing kit can produce informative match results for both major and minor contributors. 相似文献
329.
目的考察及评价AGCU Mini系统在法医学实践中的应用价值。方法应用AGCU Mini系统检测12 775份陈旧血样,进行梯度DNA模板浓度分析,并与IdentifilerTM试剂盒检测结果进行比对,评价体系的检测成功率及方法的灵敏度。针对AGCU Mini系统中D19S253基因座,对699份浙江汉族无关个体进行多态性调查。结果 12 775份陈旧血样采用AGCU Mini试剂盒检测,12 885份(96.1%)分型成功,检测灵敏度为40pg(10μL体系),方法成功率及灵敏度均高于IdentifilerTM试剂盒。D19S253基因座共检出9个等位基因,频率范围为0.005 7~0.316 2,杂合度为0.814 0,多态性信息含量为0.772 9。结论 AGCU Mini系统可用于法医微量物证的STR分析,与相关试剂盒联合使用价值更高。 相似文献
330.
《Justice Quarterly》2012,29(5):793-821
Although research regarding the impact of marriage on desistance is important, most romantic relationships during early adulthood, the period in the life course when involvement in criminal offending is relatively high, do not involve marriage. Using the internal moderator approach, we tested hypotheses regarding the impact of non-marital romantic relationships on desistance using longitudinal data from a sample of approximately 600 African American young adults. The results largely supported the study hypotheses. We found no significant association between simply being in a romantic relationship and desistance from offending. On the other hand, for both males and females quality of romantic relationship was rather strongly associated with desistance. Partner antisociality only influenced the offending of females. Much of the effect of quality of romantic relationship on desistance was mediated by a reduction in commitment to a criminogenic knowledge structure (a hostile view of people and relationships, concern with immediate gratification, and cynical view of conduct norms). The mediating effect of change in affiliation with deviant peers was not significant once the contribution of criminogenic knowledge structure was taken into account. The findings are discussed in terms of social control and cognitive accounts of the mechanisms whereby romantic relationships influence desistance. 相似文献