高效液相-二极管阵列法检测当归芍药散中主要化学成分

［摘要］目的 定性分析中药复方当归芍药散中的主要化学成分。方法 采用高相液相 二极管阵列检测法（high performance liquid chromatography-diode array detector, HPLC-DAD）,色谱柱为Welchrom XB C18 (250 mm×4.6 mm,5 μm),流动相为乙腈-0.05%磷酸水溶液（梯度洗脱）。二极管阵列扫描范围：200~400 nm。结果 通过实验并与已有文献的比较,利用HPLC-DAD检测后的三维图谱可找出中药复方当归芍药散中所含的主要化学成分川芎嗪、芍药内酯苷、芍药苷、阿魏酸、白术内酯Ⅰ、藁本内酯、23-乙酰泽泻醇B醋酸酯等。结论 HPLC-DAD可以对当归芍药散中主要化学成分做出准确定性,为其药效学研究提供依据。     

跨文化翻译维护国家文化安全的策略研究

全球化进程既是机遇亦是挑战,世界格局也因此而发生了深刻的变革。机遇意味着发展,不同文化之间的竞争也随之愈演愈烈。在不同文明的交融和碰撞中,国家文化的安全问题凸显出来。国际格局呈现出多极化趋势,文化间的交流与合作是时代的潮流,但是国际环境依然存在不确定性因素,威胁世界和平的单边主义、霸权主义和强权政治等国际因素依然活跃。复杂多变的国际形势要求维护国家文化安全,跨文化翻译涉及文化间的交流,对文化安全负有责任。跨文化翻译工作者应当树立起文化安全意识,并将其与跨文化语境意识结合起来,从国家文化安全的立场出发,提升翻译的语言水平,尊重文化差异,灵活运用“归化”和“异化”的翻译策略,形成具有中国文化特色的英语表达模式。跨文化翻译事业要重点塑造和维护国家形象,积极参与国际对话,提升中国的国际话语权,还要吸收其他国家优秀的文化成果,增强中国文化的国际影响力和感召力,打破“沉默的螺旋”。跨文化翻译要始终坚持中国传统文化的民族性和先进性。在推进翻译事业的过程中,维护中国语言文字安全、风俗习惯安全、价值观安全和生活方式安全,从而全面提升中国文化的软实力,坚定中国模式和文化产品的自信心。跨文化翻译事业将融入中国走向世界的进程,通过对精品文化的内外流通严格把关,为国家的文化安全建设保驾护航。     

复方苦参注射液生物碱类成分及血中移行成分的分析

目的 利用超高效液相色谱—电喷雾离子化—四极杆飞行时间质谱（ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry,UHPLC-ESI-QTOF/MS）结合UNIFI构建靶向筛查策略分析复方苦参注射液（Compound Kushen Injection,CKI）的生物碱类成分及血中移行成分。方法 首先,采用ESI-QTOF/MS的全信息串联质谱技术采集经UHPLC分离的CKI样品及其空白样品、CKI给药后的大鼠血浆样品及空白血浆样品的信息;然后,建立CKI生物碱化学成分数据库,与MSE数据一同导入UNIFI进行靶向筛查;依据母离子、碎片离子的精确质量对筛查出的化合物进行识别;最后,使用MassLynx 4.1工作站对UNIFI输出的结果进行核实。结果 本实验共分离、鉴定了20种CKI生物碱,其中17种生物碱能在大鼠血浆中被检出。结论 该方法能够快速分析CKI生物碱类成分及其血中移行成分,可为CKI的质量控制及药效物质研究提供参考。     

The Adaptive Capacity of Markets and Convergence in Law: UK High Yield Issuers,US Investors and Insolvency Law

This article examines the increasing access by UK issuers of high yield bonds to US investors notwithstanding substantive differences in the approach to valuation of the issuer in financial distress in US and UK restructuring law and, therefore, in anticipated return on default. It examines the development of the market in the context of existing theories on the relationship between law and finance and suggests that previous accounts have overlooked the adaptive capacity of the finance market to legal environment and the implications of such structural adaptation for the prospects of convergence in law. Three states are identified: where the market is poorly adapted to the legal environment and reinforces other pressure for change, where the market is adapted to the legal environment and is a neutral influence on, or even dampens, other pressure for change and where both legacy and adapted structures exist, potentially pulling in different directions at the same time.     

Quantitation of Synthetic Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV Detection (Validated Method)

Plant based products laced with synthetic cannabinoids have become popular substances of abuse over the last decade. Quantitative analysis for synthetic cannabinoid content in the laced materials is necessary for health hazard assessments addressing overall exposure and toxicity when the products are smoked. A validated, broadly applicable HPLC‐UV method for the determination of synthetic cannabinoids in plant materials is presented, using acetonitrile extraction and separation on a commercial phenylhexyl stationary phase. UV detection provides excellent sensitivity with limits of quantitation (LOQs) less than 10 μg/g for many cannabinoids. The method was validated for several structural classes (dibenzopyrans, cyclohexylphenols, naphthoylindoles, benzoylindoles, phenylacetylindoles, tetramethylcyclopropylindoles) based on spike recovery experiments in multiple plant materials over a wide cannabinoid contents range (0.1–81 mg/g). Average recovery across 32 cannabinoids was 94% for marshmallow leaf, 95% for damiana leaf, and 92% for mullein leaf. The method was applied to a series of case‐related products with determined amounts ranging from 0.2 to >100 mg/g.     

Chlorpyrifos Determined in Human Blood by UPLC-MS/MS and Its Application in Poisoning Cases

Objective To determine the chlorpyrifos in human blood by liquid chromatography-tandemmass spectrometry and to validate its application in poisoning cases. Methods The samples were extracted by a simpl...