Identification of 2‐(ethylamino)‐1‐(4‐methylphenyl)‐1‐pentanone (4‐MEAP), a New “Legal High” Sold by an Internet Vendor as 4‐Methyl Pentedrone

Online vendors are offering a new legal high, 4‐methylpentedrone (4‐MPD). Information for potential users provided by internet vendors of 4‐MPD includes incorrect structures and nonexistent CAS numbers. A sample of 4‐MPD was obtained and analyzed using GC‐MS, NMR, and LC‐EIS. The fragmentation data from the GC‐MS and LC‐EIS produced an M‐1 ion that suggested the molecular mass was 219 amu, rather than 205 amu as calculated for 4‐methylpentedrone. The difference in molecular mass corresponded to the addition of a methyl group. Based on the mass and fragmentation pattern, two standards were synthesized, 2‐(ethylamino)‐1‐(4‐methylphenyl)‐1‐pentanone and 1‐(4‐methylphenyl)‐2‐(propylamino)‐1‐butanone. The synthesis involved bromination of the appropriate ketone followed by the reaction with ethylamine or propylamine. Based on the NMR data and unique fragmentation patterns produced by these molecules, the sample was identified as 2‐(ethylamino)‐1‐(4‐methylphenyl)‐1‐pentanone, not 4‐methylpentedrone.     

The Regional Location of Knowledge Based Economy Activities in Israel

The article analyzes the spatial location behavior of economic activity that is knowledge based, by decomposing the Knowledge-based Economy Index developed by the OECD (1999) and elaborated by Cooke and Schwartz (2003) into major components that represent groups with different characteristics. The spatial behavior is analyzed in Israel in the years 1995–2002. We find that business services and high tech services tend to concentrate in metropolitan areas. Business services are found in the main city and high tech services in the satellite urban ring, with the outer-cities becoming stronger over time. Public services supporting the knowledge-based economy are concentrated in the center of the country, though not necessarily in the principal city, and they can represent an important tool in regional policy. The high tech manufacturing is concentrated around the big cities, mainly around the main metropolis. The other knowledge-based manufacturing activities tend to leave for the periphery.     

高职法律专业国际私法教学改革初探

高职法律专业是融理论与能力培养为一体的教育,其中国际私法教学中传统的演绎式教学方法侧重于理论灌输,不利于学生的职业能力培养,很难适应新世纪人才培养的需要,要实现高职法律专业应用性人才培养目标,对国际私法教学方法进行改革已势在必行。本文通过对目前高职法律专业国际私法教学中存在的问题进行分析,结合国际私法的课程特点,并根据笔者自己的教学经验,提出高职法律专业国际私法教学的改革方法。     

现代教育技术如何充分应用于高职教育

现代教育技术是以现代教育理念和理论为基础，现代教育技术是目前教育的优势，更是教学改革的关键措施，这就要求我们要充分应用现代教学技术，实现教学方式及学习方式的根本转变，使现代教学技术更充分的应用于高职教育。     

日本对华高技术出口政策与中日关系探析

长期以来 ,日本对华高技术出口政策不是以经济利益为动因 ,而是受到种种非经济因素的影响 ,极大地制约了对华高技术出口和与中国经贸关系的发展 ,反过来又对政治关系产生了严重影响。本文描述了这一政策的演变和现状 ,试图从日本的对华外交战略以及日本处理中美日大三角关系的角度分析其根源 ,并展望了中日高技术合作的发展大势 ,提出了中国的对策建议。     

创新高校教职工思想政治教育工作的思考

随着高等教育改革的不断深入,高校教职工的思想状况发生了较大变化,本文探讨了面对高校教职工思想反映出的问题,创新教职工思想政治工作的新方法。     

新形势下高技能人才的培养途径

目前我国的高技能人才队伍无论从数量上还是质量上都难以满足经济社会发展的需要,已成为制约我国走新型工业化道路和质量效益型发展道路的主要瓶颈。本文对如何尽快找到一条适合我国国情的高技能人才的培养开发途径,满足当前需求进行了探讨。     

以科学发展观为指导创新高职院校党建工作

科学发展观作为我国经济社会发展的理论,意义重大,高职院校的特殊性决定了党建工作的复杂性,本文就科学发展观对高职院校党建工作的指导意义作简要阐述,并就如何树立科学发展观,创新高职院校党建工作,谈点儿认识。     

RP-HPLC测定镇咳宁胶囊中盐酸麻黄碱的含量

目的:用反相高效液相色谱法测定镇咳宁胶囊中盐酸麻黄碱的含量.方法:采用Kromasil C18分析柱(4.6 mm×250 mm,5 μm),流动相:甲醇-0.1 mol/L磷酸二氢钾(40∶60),检测波长:210 nm,流速:1 ml/min.结果:盐酸麻黄碱进样量在0.96～5.76 μg(r=0.999 8)范围内呈线性关系,加样回收率为99.23%(RSD=0.64%).结论:该方法简便,结果准确可靠.     

公安机关对高危人群管理问题探析

公安工作涉及对吸毒人员、卖淫嫖娼者和流动人口的管理,针对当前艾滋病蔓延的严重态势,加强公安机关对高危人群的管理工作对遏制艾滋病传播有重要的作用。就公安机关对高危人群管理的现状、问题及策略进行研究分析可有效提高公安民警对艾滋病的自防意识和自防能力