栀子苷在正常大鼠体内的药物代谢动力学和组织分布

目的 研究栀子苷(Jasminoidin,JA)在正常大鼠血浆中的药物代谢动力学和在肝、脾、肾、脑中的分布情况.方法 采用phenomenex C18色谱柱(4.6 mm×250 mm, 5 μm),流动相为乙腈-0.1%磷酸(20∶80),流速0.8 ml/min,检测波长238 nm,柱温30 ℃.大鼠按JA单剂量...     

Lowering the age of consent: Legal,ethical, and clinical implications of adolescent-directed therapy

This article discusses a recently enacted Colorado law that aims to reduce the youth suicide rate by lowering the age of consent for psychotherapy from age 15 to age 12. The author discusses the challenges therapists face when young adolescents seek therapy without parental consent in cases involving interparental conflict. Suggestions for managing adolescent-directed therapy are offered.     

The red herring of adolescent mental health

An increase in adolescent distress and mental health symptoms has been clearly documented since the COVID-19 pandemic, as has increased exposure to adverse childhood experiences. Layer on top of these stressors being a youth of divorcing or separating high conflict families, and adolescent symptomatology can suddenly become a flashpoint for parental attention, division and conflict. Approaching cases using an ecological and family systems framework is necessary for accurate conceptualization and assessment of best interests in the context of child custody evaluations. Doing so ensures that adolescent mental health does not become a red herring in high conflict cases, leading to undue focus on the adolescent's mental health without considering other salient factors in the case, such as the broader parent conflict. Programs offered at the Center of Excellence for Children, Families & the Law at William James College designed to improve the lives of youth by addressing parental conflict are described.     

不同炮制方法对附子生物碱类成分的影响

目的 采用高效液相色谱法分析附子不同炮制品中6个生物碱的含量，研究炮制方法对附子中生物碱类成分的影响。方法 采用Waters sunfire C18色谱柱（4.6 mm×250 mm,5 μm），流速0.8 ml/min，柱温30 ℃，检测波长235 nm，流动相乙腈-四氢呋喃(25∶15)和0.1 mol/L醋酸铵溶液(每1 000 ml加冰醋酸0.5 ml)，梯度洗脱。结果 各成分分离度良好。在相应浓度范围内6个生物碱的线性关系良好（r＞0.999 1）；精密度相对标准偏差＜0.44％；加样回收率为95.1％～105.0％。结论 该方法快速、准确，适用于附子不同炮制品6种生物碱成分的定量分析。药典法和蒸制法、炒制法都能有效地降低毒性较大的双酯型生物碱类含量，而蒸制法和炒制法又能增加毒性小、疗效高的单酯型生物碱类含量，达到炮制减毒增效的目的。     

高效液相色谱法测定马兰中大黄酸、大黄素及大黄酚的含量

目的 建立马兰药材中大黄酸、大黄素及大黄酚含量的测定方法。方法 采用高效液相色谱法（high performance liquid chromatography, HPLC）。色谱柱:Kromasil-C18柱（250 mm×4.6 mm, 5 μm）；流动相：甲醇-0.1%磷酸水溶液；梯度洗脱；检测波长：254 nm；流速：1 ml/min；柱温：30 ℃。结果 大黄酸、大黄素、大黄酚浓度分别在0.253～2.530 μg/ml (r=0.999 6)、0.249～2.490 μg/ml(r=0.999 3)、0.257～2.570 μg/ml(r=0.999 7)范围内与峰面积呈良好的线性关系；平均加样回收率（n=6）分别为99.27%(RSD=1.28%)、99.78%(RSD=1.05%)、99.92%(RSD=0.83%)。结论 所建立的方法准确、可靠、简便，适合马兰药材中大黄酸、大黄素及大黄酚含量的测定。     

浅议加强检察官的素质教育

加强素质教育 ,全面提高人才素质已经成为全社会关注的热点 ,转变教育思想 ,实施素质教育也已成为教育界的普遍共识。加强检察官的素质教育 ,是国家经济发展和法制建设的必然要求 ,是服务检察工作大局 ,推动检察工作实践的根本保障。素质教育是加强检察教育培训和检察队伍建设的重要步骤。素质教育将成为检察官教育的一个重要课题。     

高利转贷罪认定中的几个问题

高利转贷罪由套取信贷资金和高利转贷两个相互关联的行为组成。高利是指高于获取贷款的利率。本罪的故意应包括实施套取信贷资金和高利转贷两部分。在实施套取资金行为时 ,行为人的故意内容是获得信贷资金 ;高利转贷时 ,目的是获取非法利益。这两部分必须密切结合在一起 ,套取信贷资金时 ,行为人已具有通过转贷牟利的目的了。     

天麻醒脑胶囊的质量控制

［摘要］目的 建立天麻醒脑胶囊的质量标准。方法 采用薄层色谱法对该制剂中天麻、远志、熟地黄、地龙、石菖蒲进行定性鉴别；采用高效液相色谱法对君药天麻中天麻素进行含量测定。结果 薄层色谱斑点清晰，阴性对照无干扰，专属性强；天麻素在0.107～1.070 μg（r=0.999 2）范围内与峰面积呈良好的线性关系，加样回收率为97.8%，RSD=2.8%（n=5）。结论 所建立的方法准确、重现性好，可为天麻醒脑胶囊质量控制提供实验依据。     

高效液相色谱法测定山核桃外蒲壳中4,8-二羟基-1-四氢萘酮的含量

目的 采用高效液相色谱法（high performance liquid chromatography, HPLC）测定山核桃外蒲壳中4,8-二羟基-1-四氢萘酮的含量。方法 采用HPLC，色谱柱为Shim-pack 18 (250 mm×4.6 mm,5 μm)，以甲醇-水-(40∶60)为流动相，流速为0.8 ml/min，检测波长为333 nm，柱温为25 ℃。结果 4,8-二羟基-1-四氢萘酮在1.13～20.34 μg/ml范围内与峰面积呈良好线性关系，r=0.999 9，平均回收率为101.8%，相对标准偏差为1.21%(n=6)。结论 所建立的HPLC准确可靠、结果稳定、重现性好，可用于山核桃外蒲壳4,8-二羟基-1-四氢萘酮的含量测定。     

Comparing targeted intervention modalities for high conflict co-parents: A quasi-experimental study

High conflict co-parents engage in recurrent litigation that significantly strains the court system and exacerbates their conflict. Given barriers to their engagement in service delivery (e.g., level of conflict, transportation, child care), it is vital to evaluate targeted interventions and to examine different intervention modalities (e.g., online, hybrid). This study compared court involvement and rates of parental agreement among 178 high conflict cases that received a multi-component intervention, either in-person or in a hybrid version. Results demonstrated no significant differences between groups in the change in number of court negotiations, child-related issues, or court services from before to after-intervention completion or in the proportion of parenting cases who reached an agreement. Both versions demonstrated significant reductions in parents' court involvement from before to after-intervention completion. These findings suggest the need for future research to evaluate the comparative efficacy of hybrid programs and in-person programs for high conflict co-parents with greater methodological rigor in light of the current study's findings and limitations.