丰富环境对脑梗死大鼠梗死灶周围血管内皮生长因子受体的影响

目的:研究丰富环境对大鼠局灶性脑梗死后梗死灶周围血管内皮生长因子受体的影响.方法:采用开颅电凝法制作SD大鼠右侧大脑中动脉缺血(MCAO)模型,术后第24小时随机分为丰富环境(EE)组和标准环境(SE)组.以免疫组织化学法检测血管内皮生长因子受体Flt-1及Flk-1的表达.结果:大鼠大脑中动脉闭塞后,缺血区神经元变性、坏死,Flt-1和Flk-1在缺血周边区表达明显增加,经丰富环境干预后,血管内皮生长因子受体表达大量增加.结论:丰富环境可促使血管内皮生长因子受体表达上调,进而促进微血管新生,有利于脑损伤修复.     

The association between body mass index and pulmonary thromboembolism in an autopsy population

Abstract: To evaluate the association between obesity and pulmonary thromboembolism (PTE) in a forensic context, 160 autopsy cases of fatal PTE were compared with age‐ and gender‐matched controls. The mean age of cases was 66 years (range 26–98 years; M/F 74:86). The mean body mass index (BMI) of cases with PTE was 30.88 (range 14.95–79.51), which was significantly higher than in the controls (mean BMI = 25.33; range 12.49–61.84) (p < 0.0001). Comparing the group with PTE with controls showed that five (3.1%) compared to 20 (12.5%) were underweight, 39 (24.4%) compared to 67 (41.88%) were of normal weight, 49 (30.63%) compared to 43 (26.88%) were overweight, 43 (26.88%) compared to 24 (15%) were obese, and 24 (15.0%) compared to six (3.75%) were morbidly obese. In each category of above‐normal BMIs, there were significantly greater numbers in the groups with PTE: overweight (p < 0.01), obese (p < 0.001), and morbidly obese (p < 0.0001).     

植物SSR标记的研究现状及其在法庭科学中的应用

随着SSR分子标记技术的深入研究,其在植物遗传多样性分析、种属鉴定、个体识别中得到越来越广泛的应用。本文就植物SSR分子标记技术的特性、发展、研究现状进行综述,并探讨其在法庭科学中的应用前景,旨在为法庭科学和相关学科中的应用和相关领域中的研究提供参考。     

马克思主义大众化研究中需要注意的几个问题——以重庆市机关人员的调查问卷为基础

当前马克思主义大众化研究正处在拓展与反思相结合的阶段,反思的深度直接决定了今后研究的重点和方向。通过对重庆市机关人员的调查研究发现,马克思主义大众化研究中要重视下述四个问题：人民群众陷入马克思主义信仰危机的说法是对马克思主义大众化的重大误解;阻碍马克思主义大众化的重要因素不在理论界,而在于党内的腐败现象;与网络、广播、电视、动漫等显性载体相比,党员干部的工作作风这一隐性载体更为重要;在马克思主义大众化的宣传手段中除了要重视“术”的运用外。更要重视对“加强人文关怀”这一“道”的遵循。     

A closer look at risk factors for public-private partnerships in Singapore: six case studies

ABSTRACT

Despite its global popularity over the past few decades, the public-private partnership (PPP) has not always led to successful outcomes, due largely to a number of risk factors associated with the projects. To explain how and why PPPs sometimes fail, this study considers the success-failure continuum of Singapore’s recent PPP experience from 2000 to 2019. After taking a critical, close look at the six failed cases, we identify the following latent risk factors: unstable financial capacity during the execution period of a project, force majeure unforeseen problems that arise, a lack of technical and/or financial foresight, poor corporate management (e.g. delays in construction and poor-quality service delivery), and an unfavourable investment environment stemming from the lack of a clear and supportive governance framework. In addition, we find that most risk factors tend to appear during the contract management (pre-operation) and project management (operation) phases. Such risks seem to drive the operational failure and subsequent contract termination of multiple unsuccessful PPPs, simultaneously (and sometimes sequentially) rather than in isolated fashion. All in all, this study offers for policymakers that better risk allocation and proper, mutual coordination between the public and private partners represent essential factors for PPP success.     

论"个别教育"在罪犯教育中的应用

监狱工作的实践告诉我们,对罪犯进行思想教育是改造罪犯的有效手段,而个别教育是思想教育的重要方式.个别教育是针对押犯的特殊问题及不同情况而对其进行细致深入的思想教育,本文阐述个别教育在罪犯教育中的针对性以及促进在押犯良性转化方面所发挥的积极作用,建立健全个别教育效果评估机制和有关法律法规,完善罪犯个别教育体系,加强国家对违法犯罪行为的打击力度,从而提高我国监狱对服刑罪犯的改造效果,体现监狱教育、改造罪犯的职能.     

GFAP和VEGF在创伤性脑损伤中表达的研究进展

创伤性脑损伤是世界上导致死亡及残疾的主要原因之一。检测对中枢神经系统损伤有高度特异性和敏感性的生物标志物,可以在一定程度上反映损伤情况。胶质纤维酸性蛋白与血管内皮生长因子均可作为颅脑损伤的生物学标记物,其表达变化规律、峰值出现时间,与创伤性脑损伤的严重程度及损伤时间的推断密切相关,对于法医病理学具有重大意义。该文对胶质纤维酸性蛋白与血管内皮生长因子的分子生物学特性及其在创伤性脑损伤中的表达进行综述。     

Construct validity and internal reliability of the Finnish risk and needs assessment form

Validation of risk and needs assessment instruments used to predict, and reduce, recidivism and misconduct is of ethical, practical and scientific importance. We argue for a focus on variable (i.e. changeable over time) risk factors, and that validation begins with establishing construct validity. The Finnish Risk and Needs Assessment Form, in Finnish Riski- ja tarvearvio (RITA), is a semi-structured interview form adapted from the Offender Assessment System used in England and Wales and consists primarily of variable risk factors. In this study, we examined the construct validity and internal reliability of RITA. The results suggest that the original RITA sections do not provide an adequate statistical model for describing the relationship between scored questions, and we, therefore, offer an improved model. In our proposed model, several scores are influenced by more than one dimension of risk and the dimensions correlate with each other considerably. We suggest that the dimensions that can be measured with RITA are Problems managing economy, Alcohol problems, Resistance to change, Drug abuse and associated behaviour, Aggressiveness and Employment problems. All factors except Drug abuse and associated behaviour had very good internal reliability. We propose this new model to be used in future research with, and in development of, RITA.     

情报信息主导侦查机制的构成要素

侦查机关要在与犯罪作斗争的过程中赢得先机,必须建立一套长期有效的侦查机制。情报信息主导侦查机制是社会信息化的产物,是新时代适应打击违法犯罪的需要。该机制主要有六部分组成,包括情报意识、硬件设施及技术、组织管理体系、专业队伍、制度及情报信息数据库等。     

中国股票型开放式基金业绩的实证分析——基于信息比率与单因素模型评价方法的对比分析

采用信息比率与单因素评价模型,使用沪深300指数构建基准投资组合,对我国2005-2007年中10只股票型开放式基金经风险调整后的业绩进行实证研究。基于信息比率的基金业绩评价指标相对于单因素模型有较明显的应用优势,同时采用沪深300指数作为市场基准的评价结果更具有可靠性。