皮肤烧伤愈合过程中磷酸化c-Jun的表达

目的观察烧伤后人皮肤磷酸化c-Jun(p-c-Jun)的变化特点,初步探讨烧伤后创面愈合的分子机制。方法取12例烧伤后住院植皮患者的烧伤周边区皮肤为实验组;另取正常皮肤12例为对照组。应用免疫组织化学方法和常规HE染色检测p-c-Jun在皮肤烧伤周边区和正常皮肤组织中的变化情况。结果对照组p-c-Jun阳性颗粒主要定位于表皮细胞和内皮细胞中,阳性细胞率为(13.9±2.7)%;实验组p-c-Jun阳性颗粒主要定位于表皮细胞和部分炎细胞中,阳性细胞率上升至(47.2±8.6)%,明显高于对照组(P0.01)。结论烧伤后人皮肤p-c-Jun的表达可能与创面愈合有关。     

论兼采扶养丧失说与继承丧失说之可行性——对死亡赔偿中消极损害内容的再澄清

对于死亡赔偿中消极损害的内容,我国学界一般认为有扶养丧失说与继承丧失说两种不同的模式,并且这两种模式相互排斥,不能并存。这一看似合理、并有各国立法例支持的认识实际上存在很大问题。事实上,兼采扶养丧失说与继承丧失说并没有不可逾越的理论障碍。立法例上所谓的大多国家/地区均采扶养丧失说也只是学说上的一种概括,具体到各个国家/地区,均有所不同,没有必然的参考意义。相反,在我国,继承利益历来受到重视,因而将其与扶养利益分开,同时设立扶养利益与继承利益两个赔偿项目,具有重要意义。因此在我国,兼采扶养丧失说与继承丧失说更为合适。     

高校学生伤害事故适用公平责任原则的分析--从我国相关立法视角所作的思考

公平责任原则能否适用于高等学校学生伤害事故,一直是高等学校学生伤害事故归责原则研究和适用中争议的焦点之一。争议在理论研究、司法实践和地方立法中的对立,实际是民法学界公平责任原则存废争议的延伸,源自对《民法通则》实施以来我国立法、司法解释,特别是《侵权法》相关规定的不同解读。对此所作的分层分析表明,我国法律既没有肯定公平责任原则的法律定位,也不存在公平责任原则适用于高等学校学生伤害事故的规定。“公平责任原则”只能作为归结法律责任以外社会责任的一项损害分担规则。     

Enhancing the Visibility of Injuries with Narrow‐Banded Beams of Light within the Visible Light Spectrum

The use of narrow‐banded visible light sources in improving the visibility of injuries has been hardly investigated, and studies examining the extent of this improvement are lacking. In this study, narrow‐banded beams of light within the visible light spectrum were used to explore their ability in improving the visibility of external injuries. The beams of light were induced by four crime‐lites^® providing narrow‐banded beams of light between 400 and 550 nm. The visibility of the injuries was assessed through specific long‐pass filters supplied with the set of crime‐lites^®. Forty‐three percent of the examined injuries improved in visibility by using the narrow‐banded visible light. In addition, injuries were visualized that were not visible or just barely visible to the naked eye. The improvements in visibility were particularly marked with the use of crime‐lites^® “violet” and “blue” covering the spectrum between 400–430 and 430–470 nm. The simple noninvasive method showed a great potential contribution in injury examination.     

建筑施工企业农民工工伤保险立法浅议

建筑行业农民工的工伤保险问题,已经引起社会各界的广泛关注。建立适合建筑行业农民工的工伤保险制度是保护农民工健康和维护社会稳定的必要条件。目前我国建筑行业农民工工伤维权存在一些问题,因此,需要建立符合我国建筑行业农民工自身特点的工伤保险。     

大鼠弥漫性轴索损伤后Homer1蛋白表达的研究

目的:观察大鼠弥漫性轴索损伤(DAI)后Homer1蛋白的表达规律。方法:将45只SD大鼠随机分为对照组及DAI组,后者按DAI后处死大鼠的时间不同分为30min、1h、3h、6h、12h、24h、72h、7d组。建立大鼠DAI动物模型,运用免疫组织化学技术及图像分析方法观察脑组织Homer1蛋白的表达。结果:损伤后30min,Homer1蛋白染色阳性细胞数增多,染色增强(P<0.05),随着损伤时间的延长,阳性细胞数及阳性表达范围逐渐扩大,于伤后24h达到高峰(P<0.01),随后逐渐下降。对照组可见少量Homer1蛋白表达。结论:Homer1蛋白是大鼠DAI后的灵敏指标,在不同时间段表达具有时序性变化规律,对于早期诊断DAI及损伤时间的推断具有一定的参考价值。     

Interpreting Injury Mechanisms of Blunt Force Trauma from Butterfly Fracture Formation

According to biomechanics of fracture production during blunt impact, tubular bones are subject to compressive (impact site) and tensile (opposite impact site) forces; this causes bones to break in tension before compression, producing Y-shaped fracture patterns with breakaway (butterfly) fragments. In current forensic models, the side of the bone exhibiting the breakaway fragment is designated the impact side, with initial breakage occurring opposite. Fracture production and patterning of blunt impacts to 255 sheep femora were analyzed. Contra the existing model, only 60% of complete butterfly fractures exhibited impact side breakaway fragments. Although fractures initiated on the tension, nonimpact side, butterfly fragments formed on either compression or tension sides. Using newly defined breakaway fragment shape criteria, impact side was estimated with 98% accuracy for both complete and partial butterfly fractures. Furthermore, the results suggest that the impact site is the located on one of the Y-fracture's arms, not the butterfly fragment's center, as previously modeled.     

CDK5的表达与脑损伤时间推断的相关性研究进展

细胞周期蛋白依赖激酶5(cyclin-dependent kinase 5,CDK5)是CDK家族中一类不直接调控细胞周期的蛋白。CDK5通过靶蛋白的磷酸化在神经细胞的发育、修复及退行性变等方面发挥着不可替代的作用。脑损伤是指暴力作用于头部造成的脑组织器质性损伤,由于损伤发生后机体启动应激及修复机制,脑组织中变化的多种蛋白及酶类物质可作为损伤时间判定的指标。本文就CDK5的分布、活性机制、生理作用及其脑损伤研究与其作为脑损伤标志物可能性的研究进展进行综述。