Classification and individualization of black ballpoint pen inks using principal component analysis of UV-vis absorption spectra

The technique of principal component analysis has been applied to the UV-vis spectra of inks obtained from a wide range of black ballpoint pens available in the UK market. Both the pen ink and material extracted from the ink line on paper have been examined. Here, principal component analysis characterised each spectrum within a group through the numerical loadings attached to the first few principal components. Analysis of the spectra from multiple measurements on the same brand of pen showed excellent reproducibility and clear discrimination between inks that was supported by statistical analysis. Indeed it was possible to discriminate between the pen ink and the ink line from all brands examined in this way, suggesting that the solvent extraction process may have an influence on these results. For the complete set of 25 pens, interpretation of the loadings for the first few principal components showed that both the pen inks and the extracted ink lines may be classified in an objective manner and in agreement with the results of parallel thin layer chromatography studies. Within each class almost all inks could be individualised. Further work has shown that principal component analysis may be used to identify a particular ink from a database of reference UV-vis spectra and a strategy for developing this approach is suggested.     

刑事附带民事诉讼死亡、残疾赔偿金审判探析

死亡赔偿金、残疾赔偿金的刑事附带民事赔偿问题，囿于立法、司法解释不明确和矛盾、司法实践中当事人赔偿能力低下、大多无财产可供执行的困难等诸因素，在是否列入刑事附带民事的赔偿范围及如何判赔问题上存在颇多争议。笔者在综合考察研究相关的立法、司法解释及刑事附带民事赔偿审判实践的基础上，主张应当列入赔偿范围且应当全额判赔。但应当给原告出具风险告知书并尽可能争取调解解决。进入强制执行阶段後，如有财产的，全额执行；如无履行能力的，则应中止或终结执行。同时，对因中止或终结执行而生活极端贫困被害人及其抚养人应给予国家补偿救济或“低保”。     

Hair analysis for cocaine: Factors in laboratory contamination studies and their relevance to proficiency sample preparation and hair testing practices

Hair samples were contaminated by rubbing with cocaine (COC) followed by sweat application, multiple shampoo treatments and storage. The samples were then washed with isopropanol for 15 min, followed by sequential aqueous washes totaling 3.5 h. The amount of drug in the last wash was used to calculate a wash criterion to determine whether samples were positive due to use or contamination. Analyses of cocaine and metabolites were done by LC/MS/MS. These procedures were applied to samples produced by a U.S. government-sponsored cooperative study, in which this laboratory participated, and to samples in a parallel in-house study. All contaminated samples in both studies were correctly identified as contaminated by cutoff, benzoylecgonine (BE) presence, BE ratio, and/or the wash criterion. A method for determining hair porosity was applied to samples in both studies, and porosity characteristics of hair are discussed as they relate to experimental and real-world contamination of hair, preparation of proficiency survey samples, and analysis of unknown hair samples.     

Comparative Analysis of the Chemical Profiles of 3,4-Methylenedioxymethamphetamine Based on Comprehensive Two-Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry (GC × GC-TOFMS)*

Abstract: The chemical profiling of illicit drugs is an important analytical tool to support the work of investigating and law enforcement authorities. In our work, comprehensive two‐dimensional gas chromatography–time‐of‐flight mass spectrometry (GC × GC‐TOFMS) combined with nontargeted, pixel‐based data analysis was adapted for the chemical profiling of 3,4‐methylenedioxymethamphetamine (MDMA). The validity and benefit of this approach was evaluated by analyzing a well‐investigated set of MDMA samples. Samples were prepared according to a harmonized extraction protocol to ensure the comparability of the chemical signatures. The nontargeted approach comprises preprocessing followed by analysis of variances as a fast filter algorithm for selection of a variable subset followed by partial least squares discriminant analysis for reduction to promising marker compounds for discrimination of the samples according to their chemical profile. Forty‐seven potential marker compounds were determined, covering most of the target impurities known from the harmonized one‐dimensional profiling as well as other compounds not previously elucidated.     

Review and Analysis on UN Security Council＇s Anti- Terrorism History

联合国宪章为安理会采取包括动用武力在内的强制行动打击国际恐怖主义提供了隐含的法律依据,如果国际恐怖主义达到危及国际和平与安全的程度,安理会就可以采取包括动武在内的强制行动介入反恐斗争。事实上,安理会已多次采取强制行动来打击国际恐怖主义。从法理方面分析,安理会可以授权以武力打击国际恐怖主义。打击国际恐怖主义与人权的国际保护并不矛盾;而保护人权,正是反恐的主要目的之一。     

论音乐作品的著作权保护

音乐作品是整个著作权作品体系中十分重要的组成部分,保护音乐作品著作权反映了我国著作权法律制度的发展水平。随着网络技术的飞速发展,音乐作品在国际范围内的交流日益加深,我国的法律制度也应该与国际接轨,因而在音乐作品的保护上建立和完善著作权限制制度和著作权集体管理制度是必然的趋势。本文首先分析了音乐作品的表演权、广播权以及网络传播权三项重要的音乐作品财产权,进而对音乐作品著作权受到侵害的情形进行分析,并提出对策建议,即完善著作权权利限制制度、著作权集体管理制度以及互联网管理制度。     

规范网络政治参与：现代民主政治发展的新思路

网络在中国的迅猛发展,深刻地影响着公民的政治参与程度和热情,推进了现代民主政治的发展进程。本文从网络政治参与的内涵和特点入手,客观地分析了网络政治参与给我国民主政治建设、政治稳定等方面带来的双重影响,并提出规范网络政治参与的对策。     

专利创造性的经济学分析

专利创造性的主要经济学理论包括选择价值理论、连续发明理论、错误成本理论和互补发明理论.这些经济学理论对深入认识专利创造性提供了有益的视角,并能够对专利政策的制定以及专利创造性判断的司法实践提供帮助.分析表明,专利实践中的很多做法都暗含了这些理论分析所隐含的经济理性,但是由于经济学理论难以提供可操作性的工具,经济分析要为政策制定和创造性判断提供具体指导还需要进一步研究.     

Rapid in situ repeatable analysis of drugs in powder form using reflectance near-infrared spectroscopy and multivariate calibration

This study takes the first step toward in situ analysis of powder drugs which does not require any alteration of the samples. A fast, inexpensive analytical method based on reflectance near-infrared (NIR) spectrometry and multivariate calibration was applied. A diode-array fiber-optic portable spectrometer in the 900-1700 nm range was employed. Samples were laboratory-prepared ternary powders (diacetylmorphine, caffeine, and paracetamol). Partial least squares regression was applied. The choice of the standard samples for calibration and validation was performed through a D-optimal experimental design. The explained variance was higher than 90%, and the relative root mean square errors were <2%. The number of principal components (6) was very low when compared with the number of raw variables (356 absorbance values). Response plots showed slopes and intercepts were very close to optimal values. Correlation coefficients ranged between 0.909 and 0.989. The method here proposed proved to be competitive with Fourier transform NIR spectrometry.     

东莞溺死案多发河段硅藻种群分布及其法医学意义

目的调查东莞溺死案多发河段硅藻种群分布,探讨其在溺死地点推断中的意义。方法于2009年6月至9月收集东莞市东江沙田、道滘、麻涌、石碣、石龙、茶山和企石共7个河段采样点江水样本126份,并收集2例已知落水地点溺死尸体;制作各样本硅藻涂片,计算样本间Sprensen相似系数及弦平方距离(SCD),并进行聚类分析。结果 126份水样中共鉴定出70种硅藻,其中优势度>0.02的优势种群有4种;2个案例样本分别与道滘和石碣河段样本的相似度最高,与实际落水地点基本一致。结论建立区域性溺死多发河段硅藻数据库,利用Sprensen相似系数及SCD值及聚类分析进行落水地点推断具有一定可行性。