手部脱落细胞DNA转移及二次转移的实验研究

目的研究脱落细胞遗留者洗手时间及所接触客体类型对手部脱落细胞转移的影响,同时考察手部脱落细胞DNA是否能够发生二次转移。方法 9名志愿者在洗手后30min、2h、6h分别握持木柄螺丝刀、橡胶柄螺丝刀、胶木插头1min和佩戴粗纱手套15min,对上述物品进行DNA提取检测,同时进行手部脱落细胞的二次转移实验。结果从志愿者接触过的物品中能够获得的STR基因座数量随着接触者洗手后时间的延长而增加;在洗手后30min和2h的触摸实验中,4种客体检出的基因座数量存在统计学差异,从手套中检出的基因座数量多于从木柄和橡胶柄螺丝刀中检出的数量;从脱落细胞遗留状态较差者握持过的螺丝刀中,检出了与该物品没有直接接触的脱落细胞遗留状态较好者部分STR基因座。结论接触者最后一次洗手时间是影响脱落细胞DNA转移的一个重要因素,在接触性DNA的提取检测和结果解释过程中,对有可能发生的二次转移现象应予以高度注意。     

深化我国乡镇管理体制改革的职能模式探析——安徽省乡镇管理体制改革全面试点透视

以当今我国全面推进乡镇管理体制改革试点为背景,动态地阐释职能模式抉择在乡镇公共管理职能转变中特殊的关键意义,以及此一选择的主要类型和应遵循的基本原则,是当下中国农村全面深化改革的迫切诉求,更是学界的理论责任。     

"此是东井冈会师天下壮"——略谈东固斗争的历史意义

东固斗争,在红军游击战争和苏维埃运动初期颇具特色,它是赣西南红军游击战争和苏维埃运动的发祥地。它承接了赣西南武装斗争中心地区的使命,在农村建立秘密根据地发展红军,点燃了赣西南红军游击战争和苏维埃运动的星星之火;它在探索中国革命正确道路的斗争中,创造了独具特色的"游击秘密割据",成为"工农武装割据"初级阶段最佳的开展形式;它以"李文林式"的斗争与"朱毛式"的斗争相呼应,坚持与发展了赣西南红军游击战争和苏维埃运动,促进了红三军和赣西南苏区的建立。     

家庭主要照顾者与我国老年人对社区服务需求的研究

通过分析2010年中国城乡老年人口状况追踪调查的数据,本文探讨了家庭主要照顾者对我国城乡老年人社区服务需求的影响。主要照顾者被分为五类,即配偶、儿子、女儿、儿媳和其他人。配偶和儿子在我国城乡老年人照顾者中所占的比例最高;儿媳在农村老年人主要照顾者中占的比例较高。对各种社区服务有需求的农村老人的比例高于城市老人;城乡老年人对上门看病和上门护理服务需求最高。回归结果表明,被配偶和女儿照顾的城市老人对社区服务有需求的可能性较小;被女儿照顾的农村老人对社区服务有需求的可能性较低。这说明被不同照顾者照料的老年人对社区服务的需求有显著差异;被儿子、儿媳和其他人照料的老年人很可能是今后我国老年社区服务的主要对象。     

The Psychopathological Profile of Cannibalism: A Review of Five Cases

In today's society, human cannibalism is extremely rare and represents an unthinkable act of violence. Scientific literature on the topic is sparse due to significant methodological problems, such as collecting enough data and generating unbiased analyses. The purpose of this article is to illustrate some psychodynamic aspects of cannibalism. After a review of the literature, we will present and compare five cannibalistic patients hospitalized in the Henri Colin secure unit (Villejuif, France). The patients described fall into two subgroups, suffering either from severe schizophrenia or from a mixed personality disorder with sadistic and psychopathic features associated with paraphilia. For the schizophrenia group, cannibalism is a self‐defense reaction to a perceived threat of destruction: survival depends on the annihilation or assimilation of the other. For the mixed personality disorder group, ego and narcissism are the central issue with a desire to overcome deep‐rooted frustrations by means of an extraordinary act.     

Identifying and classifying juvenile stalking behavior

Despite the growing research in the area of stalking, the focus has been on adults who engage in this behavior. Unfortunately, almost no studies investigate the prevalence of this behavior in adolescents. Two cases are presented demonstrating not only that stalking occurs during the period of adolescence, but also that there is a significant difference in the motivation underlying this behavior that can be classified similarly to that of adult stalkers. Further, a suggested classification based on these two cases as well as our experience with other juveniles who have exhibited stalking behaviors is proposed. The first case involves a narcissistic youth who also possesses psychopathic traits, while the second involves a lonely, severely socially awkward teen. Juvenile stalking is a societal problem that has not yet garnered the attention it deserves, and all systems that deal with juvenile delinquency (juvenile court, law enforcement, and mental health personnel) as well as the school system must be educated to the prevalence and severity of this yet-to-be-recognized problem.     

The "untreatability" of psychopathy and hospital commitment in the USA

One argument in support of a public policy of not subjecting persons with psychopathic disorders to civil or criminal commitment is that these disorders do not improve with treatment. This article examines the relationship between the assumption of untreatability of psychopathic disorders and outpatient civil commitment, inpatient civil commitment, and insanity acquittee commitment. Research on the treatability of psychopathy is reviewed and the treatment of conditions co-morbid with psychopathy is considered. Research evidence is insufficient to support the conclusion that psychopathy is improved, worsened or not affected by treatment. Evidence does support effective treatments for conditions that can be co-morbid with psychopathic disorders including impulsive aggression which can be interpreted as a manifestation of psychopathic disorder.The absence of evidence based treatment efficacy for psychopathic disorders is a logical reason for not subjecting individuals with only a psychopathic disorder to involuntary hospitalization. This assumption should not becloud the possibility of treatable co-morbid conditions which may or may not qualify for involuntary hospitalization. Where the primary mental disorder, for which an individual is involuntarily hospitalized, results in behavioral improvement, the continued presence of a psychopathic disorder itself, should not be sufficient reason to continue coerced confinement. Even so, where the primary disorder is incompletely treated, psychopathy can be considered a risk factor when deciding upon the appropriate time for discharge and when formulating a safe and effective after care plan.     

原发性脑干损伤神经元凋亡及caspase3的表达

目的观察原发性脑干损伤（PBSI）致死者脑干神经元凋亡及caspase3的表达情况,探讨其法医学意义。方法选择法医学检案中30例确定为原发性脑干损伤致死者脑干,按伤后不同存活时间（t≤5min、5min〈t≤15min、15min〈t≤1h、1h〈t≤24h）分为4组,以5例非脑干损伤死亡者脑干为对照组;分别运用常规HE、免疫组化和TUNEL染色检测中脑、桥脑及延脑重要核团内神经元凋亡及caspase3的表达情况。结果原发性脑干损伤后15min～24h出现明显神经元细胞凋亡（23.2%～35.9%）和caspase3阳性表达（28%～54%）,并呈现随损伤时间进行性增加的趋势,与对照组有显著性差异（P〈0.01）。结论原发性脑干损伤早期即出现神经元凋亡及caspase3表达增加,并随损伤时间的延长呈进行性增加,可据此辅助诊断原发性脑干损伤死亡。