Microwave-assisted extraction and differential scanning calorimetry in the chemical identification of sliming agents apprehended in the south region of Brazil

Over the past decades, consume of slimming agents considerably increased in several countries, including Brazil, due to weight-loss and stimulant properties. Since these drugs are controlled to prevent illicit and indiscriminate use, there is a parallel illegal market that uses the Internet and irregular pharmacies in order to distribute these formulations. Slimming agents produced by these illegal sources are known for being manufactured with little or none quality control resulting in uncertain and unknown formulations. For forensic purposes, apprehended pharmaceuticals have to undergo a process of chemical identification that can be difficult due to its complex matrix. In this sense, application of assisted energies in the extraction step such as microwave irradiation can be a promising method to increase the recuperation of the target molecules of the sample. Therefore, the aim of this research was to identify four slimming agents apprehended in Brazil by means of visual inspection, Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry and Gas Chromatography – Mass Spectrometry. Moreover, the efficiency of solid-liquid extraction and microwave-assisted extraction was compared. It should be noted that our work was one of the few to use Differential Scanning Calorimetry and the application of microwave irradiation in the analysis of apprehended materials. Results showed that the majority of the samples was counterfeit being composed of one or several adulterants or contaminants. Initially, visual inspection resourcefully screened the slimming agents for possible signs of falsification, however it failed to detect fraudulent products that were very similar to veridical medicines. Sequentially, Fourier Transform Infrared Spectroscopy detected functional groups present in the samples while the presence or absence of the alleged active ingredients were successfully measured with Differential Scanning Calorimetry and, thus, providing a full chemical screening of the apprehended materials. Gas Chromatography- Mass Spectrometry confirmed the presence of adulterants such as caffeine, fluoxetine and phenolphthalein as well as contaminants such as sulfurol in the falsified samples. Finally, comparison of extraction procedures indicated that microwave-assisted extraction increased the recovery of compounds detected in chromatographic analysis to a greater extent than solid-liquid extraction.     

公众人物姓名商标注册的法律规制——以公众人物姓名与注册商标权利冲突为视角

姓名具有识别功能,亦可被作为商标使用。公众人物基于自己的努力使得自己的姓名在社会公众中具有一定的吸引力,并使得自己的姓名蕴含了一定的商业价值。基于此,常有第三人欲借用公众人物对社会大众吸引力变为对商品的消费,而未经公众人物许可将其姓名注册为商标。对此情况,我国商标法以较隐蔽的方式进行限制,但法律规定的不明晰使得公众人物姓名被抢注为商标的情况仍不时发生,并直接导致公众人物姓名权与姓名商标权之间的冲突。为此,法律在商标注册时应进行规制,从知名度的认定、争议商标与公众人物姓名相同的认定以及争议商标使用的事实状态等三个方面进行考量,防止不当注册的情况产生。     

论他物权的设定

我国物权法理论主要是以所有权为中心展开对物权变动的讨论,而忽视了他物权设定的特殊性。他物权的设定与所有权的移转存在着诸多区别,原则上他物权应通过物权设定的合同加公示方法才能设定。不动产他物权设定的模式一般应采取登记要件主义。     

商事登记制度的立法完善

在我国市场经济发展的现阶段,法典意义上的"民商分立"既无可能,亦无必要。由于我国缺乏商法的传统,在商法明显的国际化与统一化的趋向下,制定《商事通则》亦是困难重重。在我国商事立法进程中,当务之急是制定一部统一的《商事登记法》。商事登记法作为商事立法的重要组成部分,体现着商法营利性的核心理念,应当以效率与安全作为立法的基本价值取向。同时在立法中应注意一些具体问题,如商事主体的确认,注册登记与营业登记的分离以及商事登记机关责任的强化等。     

重新审视我国的事实婚姻

事实婚姻是指男女双方未办理结婚登记手续 ,以夫妻名义共同生活 ,群众也认为是夫妻的一种合法婚姻。《婚姻法》的根本目的在于保护当事人的权益。事实婚姻与登记婚姻都是当事人根据自己不同的要求作出的选择 ,在不违反公序良俗的前提下 ,法律应当尊重男女双方的意思自治 ,自由选择结婚方式。     

非婚同居的规制不会冲击结婚登记制度

结婚登记制度是非婚同居产生的制度条件,非婚同居不是对现行婚姻制度的冲击,非婚同居制度与结婚登记制度可以相得益彰。法律保护非婚同居,虽在一定程度上弱化婚姻法价值导向,但并没有动摇婚姻的主流地位,破坏家庭法目标的实现。婚姻危机无法缓解,并不能因此归责于法律承认和保护了非婚同居,而应正视和反思婚姻制度自身所面临的问题。法律对非婚同居的承认,并不排斥婚姻制度,人们根据自身的需要选择不同的两性结合方式。婚姻依然是人类自我延续和子女健康成长的必不可少的组织,应将婚姻置于优先保护的地位,赋予婚姻与非婚同居不同的待遇,婚姻家庭模式的主流地位得以巩固。     

城乡统筹条件下农村集体建设用地使用权的法律问题研究

农村建设用地使用权属于用益物权.国有土地建设用地使用权可以自由进行市场交易,而农村建设用地使用权则受到较为严格的法律制约.土地确权登记应定位于确认证据事实等民事法律行为的具体行政行为.农村集体建设用地的取得包括原始取得和继受取得.因农村集体建设用地使用权所获得的收益,国家可比照国有建设用地使用权流转征收相关税费,直接按照一定比例提取收益似显不妥.要加强土地规划的执行力度,土地规划的实施要着眼于基层.严格进行土地用途管制,以用途引导用地.     

不动产登记簿错误之类型与更正登记

不动产登记簿错误可以分为权利事项错误与非权利事项错误。权利事项错误意味着登记簿上对不动产物权的归属和内容的记载不正确,而非权利事项错误则是指那些不涉及物权归属和内容的登记簿错误。二者在是否会对物权构成妨害、是否导致善意取得以及更正登记的程序上完全不同。我国《物权法》第19条区分了这两类错误,并确立了不同的更正程序与要件。当不动产登记簿上存在权利事项错误时,应由利害关系人行使更正请求权请求登记簿记载的权利人同意更正。如果权利人拒绝的,更正请求权人应诉请法院或仲裁委员会解决该民事争议。原则上,只有法院、仲裁委员会的生效法律文书才属于证明登记确有错误的证据,登记机构才能据此进行更正登记。但是,对于非权利事项错误,权利人可以通过提供证据证明登记确有错误而申请更正登记,登记机构也可以依职权进行更正登记。     

迁徙自由下户籍制度改革的构想

迁徙自由为公民所享有的基本权利之一,而迁徙自由在我国法律制度中的地位则经历了一个曲折过程。基于迁徙自由的户籍制度改革,必须重视对城乡统筹的指导,必须重视迁徙自由时机成熟的确立,必须强调自由与权利的相对性、身份与权利平等、权利与义务对等、所有权益获得是渐进分步式的。