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排序方式: 共有534条查询结果,搜索用时 31 毫秒
31.
Luiz Antonio Ferreira da Silva Beatriz Jatob Pimentel Dalmo Almeida de Azevedo Eliana Neves Pereira da Silva Simone Silva dos Santos 《Forensic Science International Supplement Series》2002,130(2-3):187-188
The polymorphism of nine STR loci has been studied in a sample of 598 individuals from the population of Alagoas, Northeastern Brazil. Determination of the allele frequencies as well as of several commonly used statistics in forensic and paternity testing were defined. The most polymorphic loci were TH01 and D7S317. The exact test demonstrated that the nine loci analyzed in the population have no deviation from Hardy–Weinberg equilibrium (P>0.05). 相似文献
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目的建立15个基因座五色荧光复合扩增体系,并调查新疆维吾尔族的遗传多态性。方法筛选STR基因座,等位基因测序后按照重复序列重复次数命名,对建立的15个基因座五色荧光复合扩增体系进行灵敏度、种属特异性、同一性及稳定性检测,对新疆维吾尔族群体进行遗传多态性分析,与西藏藏族、岫岩满族、广州汉族进行群体间比较。结果建立了15个基因座复合扩增体系,检测灵敏度为0.3 ng,具有良好的种属特异性、同一性和稳定性。新疆维吾尔族13个常染色体STR基因座的基因频率分布符合Hardy-Weinberg平衡,无连锁不平衡现象,大部分基因座在群体间差异具有统计学意义。结论建立的体系具有法医物证学应用价值,13个常染色体STR基因座在新疆维吾尔族群体多态性高,适合于亲子鉴定及个人识别,可作为现有基因座的补充。 相似文献
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Methoxetamine (MXE) is a new synthetic drug of abuse structurally related to ketamine and phencyclidine. A case of a 29-year-old male with acute toxicity related to the analytically confirmed use of MXE is reported. The man was found dead at his residence. Biological material was analyzed using liquid chromatography–tandem mass spectrometry. The concentration of MXE in urine of the deceased was 85 μg/mL. Despite the vial containing the blood sample being destroyed during transportation and the blood leaking out into the cardboard packaging, the blood level of MXE was estimated. After determination of the cardboard grammage (approx. 400 g/m3) and the mean mass of the blood obtained after drying (0.1785 ± 0.0173 g per 1 mL), the estimated blood concentration of MXE was found to be 5.8 μg/mL. The high concentration of MXE in blood and urine and the circumstances of the case indicate an unintentional, fatal intoxication with this substance. 相似文献
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An Accelerated Analytical Process for the Development of STR Profiles for Casework Samples 下载免费PDF全文
Significant efforts are being devoted to the development of methods enabling rapid generation of short tandem repeat (STR) profiles in order to reduce turnaround times for the delivery of human identification results from biological evidence. Some of the proposed solutions are still costly and low throughput. This study describes the optimization of an analytical process enabling the generation of complete STR profiles (single‐source or mixed profiles) for human identification in approximately 5 h. This accelerated process uses currently available reagents and standard laboratory equipment. It includes a 30‐min lysis step, a 27‐min DNA extraction using the Promega Maxwell®16 System, DNA quantification in <1 h using the Qiagen Investigator® Quantiplex HYres kit, fast amplification (<26 min) of the loci included in AmpF?STR® Identifiler®, and analysis of the profiles on the 3500‐series Genetic Analyzer. This combination of fast individual steps produces high‐quality profiling results and offers a cost‐effective alternative approach to rapid DNA analysis. 相似文献
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22号染色体4个STR基因座的遗传多态性及连锁关系 总被引:3,自引:2,他引:1
目的 研究22号染色体上4个STR在中国成都汉族群体的分布,开发新的STR应用于法医学应用。方法 103份汉族无血缘关系的个体血样,及10个三代家系采自成都。用PCR技术分别对4个STR基因座进行扩增,所有基因座均采用非变性聚丙烯酰胺凝胶不连续缓冲系统水平电泳进行分型,银染。应用Linkage软件包的CILINK软件对4个基因座进行连锁分析。结果 通过4个STR的群体遗传学分析,D22S686、D22S533、D22S685和D22S445的个人识别率分别为0.875、0.913、0.923和0.84,它们的非父排除率分别为0.522、0.538、0.624和0.490。在家系调查中,发现D22S685存在一例突变。结论 这4个STR具有很好的多态性,可作为法医学个人识别和亲权鉴定新的候选遗传标记。 相似文献
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浙江汉族人群6个Y—STR基因座的遗传多态性调查及法医学应用 总被引:5,自引:0,他引:5
目的获得6个Y-STR基因座及其单倍型在浙江汉族人群中的遗传多态性分布,并探讨其法医学应用价值。方法应用Y-plex荧光标记复合扩增系统,对浙江汉族200名无关男性个体进行6个STR基因座的复合扩增,用ABI3100型基因分析仪对扩增产物进行检测,统计6个Y-STR基因座的群体遗传学参数。结果其中5个Y-STR基因座分别检出5、7、6、6、5个等位基因,DYS385基因座检出47种单倍型,GD值最低为0.4275(DYS391),最高为0.9584(DYS385);观察到6个Y-STR基因座共同构成的单倍型159种,其中有132种单倍型只出现1次,16种出现2次,6种出现3次,2种出现4次,2种出现5次,累计GD值为0.9967。结论6个Y-STR基因座具有较强的个体识别能力,可应用于浙江法庭科学中的个体识别与亲权鉴定。 相似文献
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禁止内部人短线交易立法若干问题研究 总被引:2,自引:0,他引:2
内部人短线交易是一种特殊的证券内幕交易行为 ,具有较大的社会危害性。文章对规制内部人短线交易的必要性进行了剖析 ,分析了短线交易行为的构成要件 ,最后探讨了短线交易归入权行使的主体、期间以及所得收益的计算问题。 相似文献
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Prior research has shown that victimization incidents are disproportionately concentrated among relatively few victims and that prior victimization is a consistent predictor of future risk. This paper expands existing knowledge on victimization by describing temporal patterns of risk and by developing and testing alternative explanatory models of the link between past and future risk. Analyses based on panel data from the National Youth Survey support both state dependence and heterogeneity interpretations of the correlation in risk over time. In other words, prior victimization predicts future risk in part because it alters something about the individual, and because it indicates an unmeasured propensity for victimization that persists over time. The theoretical implications of these findings, including the feasibility of a victim labeling perspective, are discussed.An earlier version of this paper was presented at the annual meeting of the American Society of Criminology, Phoenix, 1993.An exception to this lack of attention is the vast literature in the area of domestic abuse. 相似文献