EA-YPredictor:基于Y-STR数据的家系特异性单倍群归属判别分析软件

目的Y染色体为男性所特有,其遗传标记蕴含着丰富的生物地理信息,故可溯源家系,在嫌疑人排查和追踪中发挥作用。Y-STR突变率较高,而Y-SNP突变率极低,几乎不会发生回复突变,所以后代男性群体携带祖先特有的Y-SNP。本研究期望通过现在我国Y库建设中通用的17个Y-STR的单倍型数据预测Y-SNP单倍群细支。方法基于前期观察,选取千人基因组计划III期中的513例东亚人群(中国及周边区域)作为基础数据集,在Java平台和Microsoft Excel软件框架下,以遗传距离计算和Y染色体进化树构建手段相联合研发Y-STR数据的家系特异性单倍群归属判别分析软件:EA-YPredictor。结果本研究揭示了15个单倍群大支下的核心单倍型。通过随机选取70个公开数据库样本,EA-YPredictor软件预测准确性达到92.8%(95%置信区间:[84.1%,97.6%])。结论在Y-SNP复合扩增检测尚无定论的情况下,本软件可基于二代测序样本对Y-STR数据库样本进行单倍群细支的准确预测,能适用于辅助家系单倍群判断。随着测序技术的不断换代和优化,更多高通量的Y-STR和Y-SNP数据补充将会使本软件进一步优化。此外,本软件对于Y数据库中Y-SNP遗传标记的筛查建库有一定指向作用。     

The Effects of Single Parenthood on Educational Aspiration: A Comparative Study of Children in the United Kingdom and Hong Kong

Using data collected by the Organization for Economic Co-operation and Development's Program for International Student Assessment in 2003, this study examines the gap in the educational aspirations of children from single-parent families and two-parent families in the United Kingdom (UK) and Hong Kong. Consistent with previous research on the relationship between cultural orientation and academic motivation, our analysis shows that children in the UK have statistically significant lower levels of educational aspiration than those in Hong Kong. Moreover, children from single-parent families in the UK and Hong Kong are found to have statistically significant lower levels of educational aspiration than those from two-parent families. Further analyses indicate that family capital and school experience are important factors for understanding the negative effects of single parenthood. Finally, we observe that single parenthood has a less negative effect on educational aspiration in the UK than it does in Hong Kong, which can be explained by differences in government family policy and family capital between the two regions. Based on the outcomes from the current analysis, we put forward several policy and service recommendations for improving children's educational aspiration and enhancing family well-being.     

The choice of electoral systems in new democracies: a case study of South Korea in 1988

Most theories about electoral system choice are based on the experiences of Western European countries, many of which shifted from majority/plurality rule to proportional representation (PR) at the turn of the twentieth century. This article aims to explain the choice of the South Korean legislative electoral system in 1988 as an example of electoral institution choices in new democracies, which may be different from those in the Western European countries. Through analysing multiple steps leading to the choice of a single-member district plurality voting system, this article suggests three potentially generalizable findings. First, in new democracies, labour parties can only induce old parties to shift to a proportional representation system if they have mobilized the working class prior to democratization. Secondly, parties in the developing world at times face unusual systems that are neither majoritarian nor fully PR. Under such unusual systems, party size would not be a reliable predictor for the party's preference over electoral institutions. Finally, when parties choose a legislative electoral institution in a presidential system, parties tend to prefer an institution that helps them in the subsequent presidential election even though the institution might harm them in the upcoming legislative election.     

DGGE技术检测小核核糖核蛋白多肽N基因rs220030位点的多态性

目的 分析小核核糖核蛋白多肽N(small nuclear ribonucleoprotein polypeptide N,SNRPN)基因SNP位点rs220030在中国汉族人群中的基因结构特征及多态性,获得群体遗传学资料.方法 应用变性梯度凝胶电泳(denatu^ng gradient gel electropho...     

Single and Married Women in the Law of Israel – a Feminist Perspective

This paper examines the ways Israeli law differentiates betweensingle and married women. The first section explores the littlewe know of single women and single mothers' realities. The secondsection analyses Israeli laws related to military service,housing assistance, homemakers' status in the social securitysystem, ways of becoming a mother, and public support formothers. The legal analysis reveals complex distinctions betweensingle and married women ranging from ignoring single women whenthey have no children and encouraging them to marry, toambivalence towards single women who want to conceive, and ontosubstantial public support for single women who are alreadymothers. The article points to directions of change needed so thelaw will adequately address single women's choices and needs.     

Process Tracing in Public Administration: The Implications of Practitioner Insights for Methods of Inquiry

The field of public administration is often seen as a late adopter of cutting-edge research methods. Related disciplines like political science use more advanced research methods for single or small-n case studies including techniques like process tracing. Many elements of process tracing are analogous to investigations. To inform process tracing practices, political scientists looked at Sherlock Holmes novels. We draw on the experiences of a police inspector and a former soldier who worked with intelligence to offer insights on the implementation of process tracing, bridge the academic–practitioner gap, and increase the methodological rigor in public administration research.     

Simplification： A single tax and a single entitlement

The United States is experiencing a very serious economic downturn. It is now necessary to consider some significant changes in government policy. The system of revenue collection should be simplified with a single tax levied and itemized at the national, state, and local levels. Likewise, the system of benefit distribution should be simplified with a single entitlement paid to each individual at every level with absolutely no strings attached. Such simplification would save a massive amount of time and money even if it was neutral in terms of overall revenue and expenditure. And, it would minimize fraud, waste and abuse. The gains in efficiency and accountability would be enormous.     

绑架罪基本要件问题探讨

绑架罪侵犯的客体是单一客体.绑架罪的实行行为是单一行为而不是复合行为.已满14周岁不满16周岁的人实施绑架行为并故意杀害被绑架人的,应以故意杀人罪论处.     

UK Labour and the EU Single Market: ‘Social Europe’ or ‘Capitalist Club’?

This article looks at the UK Labour Party’s view of the EU single market over the last four decades, focussing on three case study periods when this issue was particularly salient: first, the time of the single market’s introduction under Neil Kinnock’s leadership; second, the A8 accession with Tony Blair as Labour Prime Minister; and third, between the 2016 European referendum and 2019 general election during Jeremy Corbyn’s time as party leader. This historical narrative uses the theoretical approach of Harvard economist Dani Rodrik—of a ‘trilemma’ faced by national policy makers in response to globalisation—as a lens to describe a clear arc in Labour’s policy towards the single market across the three case studies. A position of initial scepticism moved to support under Kinnock’s leadership, and then active encouragement under Blair, before coming back again under Corbyn to uncomfortable non-commitment. This arc directly correlates with the ebb and flow of the party’s overall economic approach—first the Keynesian, national Alternative Economic Strategy at the time of the party’s 1983 general election defeat; then, the deviation under Blair to a policy that actively encouraged cross-border market liberalisation; and finally the return to an Alternative Economic Strategy-style approach under Corbyn.     

Stigmatized portrayals of single women: a content analysis of news coverage on single women and single men in China

This study explored the stigmatized portrayals of single womanhood in news media by content analyzing news coverage from Mainland China of single women and single men from 2008 to 2013. Among the three prevalent news frames (conflict, responsibility, and human interest), the results showed that news reports relating to single women commonly employed more human-interest frames and concentrated on single women’s conflicts with other social groups as well as the conflicts between singles and societal expectation of population sustainability. News stories also unduly ascribed the responsibility for being ‘single’ to the women themselves, but such individual attribution was not applied to single men. As an exploratory study, our research shed light on how news framing is gendered to reinforce stereotypes and facilitate mechanisms for control. Theoretical and practical implications are discussed in relation to public opinion about single womanhood and the intersectional oppression of single women in Chinese society.