缺氧相关microRNA在窒息死亡原因推断中的意义

在缺氧条件下microRNA(miRNA)能与转录因子等相互作用,调节细胞代谢,血管再生,血细胞生成,细胞增殖、分化及凋亡等生理过程,这些过程可能在窒息导致的死亡中发挥重要作用。本文拟对缺氧条件下miRNA的调节功能及缺氧对miRNA生物合成的影响进行综述,以期为miRNA在法医学窒息死亡原因推断中的研究提供新思路。     

同心圆理论

同心圆理论是系列性刑事案件三大侦查理论之一,源于城市结构模型理论,指的是以系列性案件的首发案为圆点、以信息源为依据、以到达系列性案件各子案发案地直线距离为半径,通过几何的方式勾画出犯罪人的活动半径,进而确定犯罪人的居住地和犯罪人的侦查方法。同心圆的原点是系列性案件的首发地,是信息源中元信息的集聚区,反映的是系列性案件中所有个案与首案之间的联系。圆半径的长短,反映了犯罪人对环境熟悉程度的变化,距离越短,其对环境的熟悉程度越高。同心圆理论解决了系列性案件侦查范围划分问题,有积极的实践意义。     

人类命运共同体视域下中国责任建构研究——基于对"中国责任论"的反思与批判

面对百年未有之大变局,中国积极承担国际责任,倡导和构建共赢共享的人类命运共同体.作为中国责任体现的人类命运共同体是对中华优秀传统文化基因的传承,是中国共产党对世界责任的自觉担当,是中华民族实现从站起来、富起来到强起来的历史性飞跃,是实现中华民族伟大复兴的必然要求.在建构人类命运共同体过程中,中国承担和履行人类命运共同体的价值责任、中国的国内责任和国际责任、人类的未来责任.人类命运共同体是对形形色色的"中国责任论"的正面回应和超越,是中国负责任大国的体现和担当.     

What would John Griffith have made of Jonathan Sumption's Reith Lectures?

In his 2019 Reith Lectures on the rise of law and decline of politics, Jonathan Sumption presents a thesis that, on its face, seems identical to that of J.A.G. Griffith's defence of the political constitution. Given the radical differences in their views on equality, democracy, and redistribution—with Griffith working in the tradition of democratic socialism espoused by the Webbs, Tawney and Laski, and Sumption expressing the libertarian philosophy underpinning Thatcherite policies—this is puzzling. This article sets their views in historical and political context and argues that the similarities are superficial, whereas the differences are profound. It then proceeds to show the weaknesses in Sumption's defence of his thesis.     

Digital behavioral-fingerprint for user attribution in digital forensics: Are we there yet?

the need for a reliable and complementary identifier mechanism in a digital forensic analysis is the focus of this study. Mouse dynamics have been applied in information security studies, particularly, continuous authentication and authorization. However, the method applied in security is void of specific behavioral signature of a user, which inhibits its applicability in digital forensic science. This study investigated the likelihood of the observation of a unique signature from mouse dynamics of a computer user. An initial mouse path model was developed using non-finite automata. Thereafter, a set-theory based adaptive two-stage hash function and a multi-stage rule-based semantic algorithm were developed to observe the feasibility of a unique signature for forensic usage. An experimental process which comprises three existing mouse dynamics datasets were used to evaluate the applicability of the developed mechanism. The result showed a low likelihood of extracting unique behavioral signature which can be used in a user attribution process. Whilst digital forensic readiness mechanism could be a potential approach that can be used to achieve a reliable behavioral biometrics modality, the lack of unique signature presents a limitation. In addition, the result supports the logic that the current state of behavioral biometric modality, particularly mouse dynamics, is not suitable for forensic usage. Hence, the study concluded that whilst mouse dynamics-based behavioral biometrics may be a complementary modality in security studies, more will be required to adopt it as a forensic modality in litigation. Furthermore, the result from this study finds relevance in other human attributional studies such as user identification in recommender systems, e-commerce, and online profiling systems, where the degree of accuracy is not relatively high.     

行政诉权分层保障机制优化研究

基于当事人行政诉权行使理性化程度的不同,可将其区分为理性行使、精明行使、不当行使和恶意行使等四种状态,行政诉讼法实施应当进一步健全行政诉权分层保障机制。对理性行使行政诉权者应当给予有效保障,从科学把握立案登记和审查关系、法官履行释明诉讼类型选择义务、灵活运用行政案件协调化解机制等三个方面进行优化。对精明行使行政诉权者应当给予适度容忍,健全诉讼风险交流机制和诉讼繁简分流机制。对不当行使行政诉权者应当给予必要矫治,完善诚信诉讼的程序规则支撑和诉讼失权制度的精准适用。对恶意行使行政诉权者应当给予严厉制裁,探索差异化立案审查和诉讼失信人信用惩戒机制。行政诉权分层保障机制的优化,对于立基于全民守法的法治社会建设具有重要的促进作用。     

ABO基因分型与多重STR联合检测在法医学中的应用

目的建立ABO基因型和Goldeneye16A试剂盒联合检测的方法,并评价其在法医学实践中的应用价值。方法将6种ABO基因型(A/A,A/O,B/B,B/O,A/B,O/O)的序列特异性引物(PCR-SSP)检测方法与Goldeneye16A试剂盒相整合进行同步分型。通过对460份男性个体血痕样本、9947A DNA及90份案件样本进行检测,考察方法的一致性、灵敏度及对法庭科学检材的适用性。结果应用本文方法可同时检出6种ABO基因型和15个常染色体STR基因座及性别决定基因座,检测灵敏度为125pg,其中ABO基因检测灵敏度达63pg。460份男性血痕和90份案件检材证实该联合分型方法用于各类检材结果准确、稳定。结论本文ABO基因分型与多重STR联合检测方法,适用于各类含有核细胞的生物检材,在法庭科学DNA鉴定中有较好的应用前景。     

国产Goldeneye~(TM) 20A试剂盒性能指标验证

目的测试国产GoldeneyeTM20A试剂盒技术性能指标,评估其法医学应用能力。方法从方法学验证、准确性、峰值均衡性、灵敏度、批次间试剂及稳定性测试、耐受性、不同检材的适应性与一致性、种属特异性、混合样本等9个方面对GoldeneyeTM20A试剂盒进行测试。结果阳性DNA样本分型正确,内标和等位基因分型标准物符合要求;等位基因间的均衡性≥83%,同一荧光标记基因座间的均衡性≥55%,不同标记物间的均衡性≥52%;0.125ng DNA阳性样本可检出全部STR基因座分型,不同批次间和反复冻融后试剂盒测试可以获得正确分型,对降解检材和混有抑制剂的样本等具有一定的耐受性,能对案件中多种检材进行分型且分型结果一致,具有一定的种属特异性和混合DNA样本检测能力。结论国产GoldeneyeTM 20A试剂盒可用于法庭科学实际检案与建库。     

The Adaptive Capacity of Markets and Convergence in Law: UK High Yield Issuers,US Investors and Insolvency Law

This article examines the increasing access by UK issuers of high yield bonds to US investors notwithstanding substantive differences in the approach to valuation of the issuer in financial distress in US and UK restructuring law and, therefore, in anticipated return on default. It examines the development of the market in the context of existing theories on the relationship between law and finance and suggests that previous accounts have overlooked the adaptive capacity of the finance market to legal environment and the implications of such structural adaptation for the prospects of convergence in law. Three states are identified: where the market is poorly adapted to the legal environment and reinforces other pressure for change, where the market is adapted to the legal environment and is a neutral influence on, or even dampens, other pressure for change and where both legacy and adapted structures exist, potentially pulling in different directions at the same time.