新风胶囊对佐剂性关节炎大鼠血清IL-1、TNFα、IL-4及IL-10的影响

目的：观察新风胶囊对佐剂性关节炎的治疗作用及对细胞因子系列（IL－1、IL－4、IL－10及TNFα）的影响。方法：将50只大鼠随机分为正常对照组，模型对照组，新风胶囊组，雷公藤多苷片（TPT）组和甲氨喋呤TX）治疗组，每组10只，制备完全佐剂并分别向除正常组以外的其余动物右后足跖皮内注射0．05ml致炎，观察各组血清中各细胞因子含量的变化，结果：与治疗前比较，新风胶囊治疗组，TPT治疗组及MTX治疗组治疗后大鼠的关节炎指数（AI）显降低（P＜0．05或P＜0．01），新风胶囊治疗组给药后体质量增加值与正常对照组比较差异无显性（P＞0．05）；TPT治疗组及MTX治疗组给药前后体质量增加值显低于正常对照组和新风胶囊治疗组（P＜0．01），与模型对照组相比，新风胶囊治疗组的IL－1，TNFα显降低，IL－4，IL－10显升高（P＜0．01），并与其余两治疗组无显性差异（P＞0．05），结论：新风胶囊与MTX，TPT一样能降低佐剂性关节炎模型大鼠的AI，而在增加大鼠体质量方面优于TPT和MTX，新风胶囊可能通过下调致炎因子（IL－1，TNFα），上调抗炎因子（IL－4，IL－10），抑制致炎效应，增强抗炎效应，从而达到降低AI，消除肿胀的治疗目的。     

十年来我国妇女/性别理论研究的发展--联合国第四次世界妇女大会产生的积极影响

从1995年第四次世界妇女大会在北京的筹备和召开,到后来举行的北京 5和北京 10等一系列相关的活动,世妇会的原则和理念得到了不断的强化,这些理念凝结和渗透在妇女理论研究领域,极大地推进了我国妇女/性别理论研究事业的发展。本文回顾了十年来妇女/性别理论研究在研究内容、研究视角及研究机制等方面的变化和进展,以期进一步推动我国的妇女/性别研究在社会科学研究领域的重要影响。     

大学英语评估系统的现状及改革建议

当前的大学英语教学评估系统包括三个子系统:基础阶段结束时的四、六级英语考试;各学期期末的学业考试;社会对大学生英语综合能力的需求和评价。但是,由于许多学校和用人单位都把四、六级考试作为考核的终极标准,导致现在的大学英语教学整个只是围绕四、六级考试进行,而四、六级考试本身又存在许多问题,造成了一种恶性循环;各学期期末的学业考试失去了其本身的意义,只是一种四、六级考试的模拟;学生也缺乏适当的途径去了解社会对英语运用能力的实际需求。这三个子系统对大学英语的教学产生了严重的负面反拨效应,要想对大学英语进行改革,首先就要从评估系统着手。     

论未成年人轻罪犯罪记录封存制度——我国新《刑事诉讼法》第275条之理解与适用

未成年人轻罪犯罪记录封存制度的适用对象除被判处五年有期徒刑以下刑罚的未成年犯外,未成年人相对不起诉和附条件不起诉记录封存也应参照适用,而且,从长远来看,应适用于所有未成年人;在法律效力上应严格限定但书中"国家规定"的范围,并协调与其他相关法律的关系;适用主体除公安机关、检察院、法院和未成年犯管教所外,还包括知晓未成年人犯罪记录的有关机关、单位以及当事人、辩护人、诉讼代理人和其他知晓其犯罪记录的个人。为充分发挥该制度的重要价值,应当将其"升级"为未成年人犯罪记录消灭制度。     

中国与越南关系2012～2013年回顾与展望

本文主要是对2012年中越关系进行回顾，对2013年面临的问题作一些分析预测，并就发展中越关系提出一些建议。     

The Stability of 4-Chloromethcathinone in Blood and Vitreous Humor

We present results of our study on the stability of 4-chloromethcathinone (4-CMC) in authentic postmortem peripheral blood and vitreous humor samples. The stability of 4-CMC was determined in postmortem blood samples (for a period of 90 days) and vitreous humor (30 days) at three different temperatures: −15°C, +4°C, and + 23°C. The analyses were carried out using ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS). In both materials, the lowest 4-CMC stability was demonstrated at room temperature. The blood samples stored in a freezer (−15°C) showed stability for the entire study period (90 days), while in the case of the vitreous humor sample stored at the same temperature the concentration of the substance decreased by 53% after 30 days. The study carried out in authentic postmortem blood and vitreous humor samples confirms the previous reports of 4-CMC instability in biological material. Authors suggest that the biological material should be stored frozen until analyses are carried out as soon as possible after collection of the material.     

Policy Adoption and Policy Intensity: Emergence of Climate Adaptation Planning in U.S. States

The United States is experiencing growing impacts of climate change but currently receives a limited policy response from its national leadership. Within this policy void, many state governments are stepping up and taking action on adaptation planning. Yet we know little about why some states adopt State Adaptation Plans (SAPs), while others do not. This article investigates factors that predict the emergence of SAPs, both in terms of policy adoption and policy intensity (goal ambitiousness). Applying the diffusion of innovation theory, I consider the relative influence of internal state characteristics, regional pressures, and test for conditional effects between government ideologies and severity of the problem. The results show interesting differences between predictors that influence policy adoption and ambitiousness. States are more motivated to adopt a policy when faced with greater climate vulnerability, have more liberal citizenry, and where governments have crossed policy hurdles by previously passing mitigation plans. The intensity of policies and goal setting, moreover, is more likely to be driven by interest group politics and diffuse through policy learning or sharing information among neighboring states in Environmental Protection Agency regions. These findings support an emerging scholarship that uses more complex dependent variables in policy analysis. These variables have the potential to differentiate symbolic from substantive policies and capture finer information about predictors of importance.     

Making a Place for Alternative Technologies: The Case of Agricultural Bio‐Inputs in Argentina

This article characterizes the ways in which the actors in charge of designing and implementing public policies intervene to promote the emergence of alternatives to problematic technologies. It is based on a case study conducted in Argentina that focuses on initiatives to promote the development of biological agricultural inputs in the context of increasingly controversial chemical inputs. The study spotlights the political, institutional, and semantic efforts made by policy makers and public administrations to ensure these new inputs find their way into organizations and onto their agendas. Their work consists in attenuating the boundaries between chemical and biological inputs, and reducing opposition by creating categories and organizations that downplay potential dissension and highlight the possible coexistence of technological paradigms. Contrary to what the injunctions of technological substitution suggest, we show that putting alternative technologies on the public agenda depends largely on their inclusion in institutional and regulatory infrastructures originally designed for technologies that are likely to decline. More broadly, it relies on the construction of continuity between the two types of technologies.     

Exploring the Effects of North–South and South–South Research Collaboration in Emerging Economies,the Colombian Case

International research collaboration (IRC) is associated with both positive and negative effects on the performance of research in emerging economies. While some authors claim that North–South collaborations improve scientific quality and visibility for Southern countries, others claim that it may entail the reorientation of research to comply with Northern agendas. South–South collaborations are thought to increase the focus on local affairs, therefore leading to a relatively small number of scientific international publications appearing in “high quality” journals. Research on the impact of IRC beyond publications in international journals has been neglected despite the importance of other products in knowledge creation. This research uses a broad range of scientific outputs to empirically assess such assumptions and explore the outcomes of IRC in Colombia. Results from multivariate regressions and nonparametric analyses show that, contrary to common assumptions, Colombian research teams collaborating with partners from the global South report higher scientific production, while those collaborating with Northern countries seem to contribute to local knowledge the most.     

Determinants of Firm‐Level Lobbying and Government Responsiveness in Agricultural Biotechnology in China

Understanding what stimulates agribusiness firms to lobby the government and what makes the government responsive to lobbying are the two issues that have been discussed extensively in the debates concerning determinants of biotechnology policy. This paper examines the factors influencing agribusiness firms' lobbying and government response using econometric modeling on a new data set of 160 leading agribusiness firms in the food, feed, chemical, and seed industries in China. The results show that approximately 10% of agribusiness firms lobbied the government about biotechnology policy and regulations and over half of those that lobbied received a verbal or written acknowledgment from government agencies. Seed and feed companies are more likely to engage in lobbying than chemical companies. Owning GM patents not only has a positive impact on firms' lobbying activities, but firms with these patents are more likely to receive a government response to their lobbying efforts. The experience of selling GM products does not significantly influence lobbying activities or response from the government.