当归芍药散对慢性心力衰竭大鼠机体水液代谢障碍的作用及其机制

目的 探讨当归芍药散对慢性心力衰竭(chronic heart failure, CHF)大鼠机体水液代谢障碍的影响及作用机制。方法 将72只大鼠随机分为正常组,模型组,芪苈强心胶囊组,当归芍药散低、中、高剂量组,每组12只,最终正常组,模型组,芪苈强心胶囊组,当归芍药散低、中、高剂量组纳入实验的大鼠数分别为8、6、8、7、8、8只。采用少量多次腹腔注射阿霉素复制CHF大鼠模型。给药4周后,采用心脏彩色多普勒超声仪测定各组大鼠左心室射血分数(left ventricular ejection fraction, LVEF)、左心室短轴缩短率(left ventricular fractional shortening, LVFS);HE染色观察心肾组织损伤情况;全自动生化分析仪检测心功能和肾功能指标[肌酸激酶(creatine kinase, CK)、肌酸激酶同工酶(creatine kinase isoenzyme, CK-MB)、乳酸脱氢酶(lactate dehydrogenase, LDH)、血清肌酐(serum creatinine, SCr)、尿素氮(urea nitrog...     

基于中枢-外周-中枢闭环康复理论探讨脑卒中后平衡障碍的治疗策略

改善卒中后平衡能力是脑卒中恢复过程的关键。本研究基于康复领域新理念,即中枢-外周-中枢闭环康复理论,探讨脑卒中后平衡功能障碍的针刺康复综合治疗方案。通过纠正感觉输入与强化正确运动模式等自下而上的外周干预手段及激活相应脑区功能的自上而下的中枢干预手段整体促进卒中后平衡障碍,以提高临床疗效,加速患者康复,为卒中后平衡障碍的临床治疗提供新的思路。     

Judicial decision-making in family court involving children with autism spectrum disorder

The prevalence of autism spectrum disorder (ASD) in children and adolescents has increased over the past decade. Consequently, the courts and experts are more likely to be exposed to these children whose needs are highly heterogeneous. The present study aims to document judicial decision-making about children with autism spectrum as well as the parenting recommendations made by experts involved in these cases. There were 104 court decisions reviewed in Quebec over the past ten years. The results show that 85.6% of the decisions included a child custody assessment and that judges are more likely to order primary care to mother (56%). However, shared parenting (27%) and primary care to the father (17%) were also ordered in disputes involving an autistic child. Bivariate analyses revealed that challenges with parental monitoring and supervision were associated with court-ordered parenting arrangements. The present study revealed that a child custody assessment as well as father custody are more often observed than in the general population. This study highlights the need for further research to shed light on the best interests of children with ASD following the separation of their parents.