Buttressing regulation of cognitive enhancement devices with principles of harm reduction

Maslen and colleagues offer an excellent model for regulating cognitive enhancement devices (CEDs), and we largely endorse their approach of extending medical device policy to include CEDs. Maslen et al. argue that since the risks and benefits of CEDs can be identified, consumers are best placed to evaluate the impact of these effects on their own wellbeing: ‘experts are to assess what the risks are, the consumer how much they matter’. In principle, we agree: consumers should be allowed to decide what risks are worth taking, but the situation is somewhat more complicated, for the evidence that consumers are in a strong position to evaluate the many risks associated with CED use is lacking. Indeed, a glance at online forums on CEDs suggests that undue risks are already being taken. Importantly, given the ease with which devices can be built using easily obtainable parts, overly tough regulation will not effectively curtail use, but rather push it underground. For these reasons, we suggest that any regulatory framework be buttressed by principles of harm reduction, providing real-world users with expert-backed recommendations for safe use. We argue for the development of tools that facilitate this dialogue, while recognizing the challenges in so doing.     

Regulation of cognitive enhancement devices: commentary

Maslen et al. (2013) have provided us with a comprehensive overview of the current legislation regulating non-clinical cognitive enhancement devices (CEDs) in the European Union and have proposed a specific model whereby CEDs would be regulated in the same way as medical devices. An alternative model would be to require manufacturers to quantify risks only. Irrespective of the purported ‘benefits’ of a product, this would allow the consumer freedom of choice to use the product at their will and allow the periodic review of worthwhile indications and unexpected adverse events. Although this departs from the standard Cochrane-type assessment, it takes into account the facts that (i) the evaluation of clinically used cognitive enhancement techniques may not be as rigorous as one might expect, (ii) variations and case-by-case use might be widespread, and (iii) independent variables of significance and useful endpoints may not be obvious ab initio. We consider cerebrospinal fluid diversion techniques which are widely used clinically to enhance cognition in patients with normal pressure hydrocephalus despite any large-scale clinical studies demonstrating substantial benefit, and the real risks of paralysis and death from these invasive procedures. The risks of CEDs which have been available for some time need to be kept in perspective: are the risks really more than using conventional cognitive enhancement techniques such as imbibing too caffeinated drinks? Furthermore, the loss of Europe as a market for CEDs which do not comply with the proposed regulatory model implies a potential gain in the market for other parts of the world. This could impact on the ability of companies in Europe being able to compete in an evolving market demand for CEDs. Legislation to regulate CEDs should be guided by the principle of ‘do no harm’ and allow for innovation and competition.     

打造国际品牌提高企业经济效益--以格力电器为例

任何一家企业其生产经营的核心目标就是追求利润,因为利润是企业的血液,如果没有利润,企业就无法生存,更谈不上长足发展。经历了一场全球性的金融危机后,在全球经济举步维艰、市场需求持续不振的大环境下,海内外家电巨头纷纷陷入困境。然而在激烈的国际竞争市场上,在国内劳动力和原材料价格不断提升、难以取得核心技术突破的情况下,格力电器却做出了非常明智的抉择,即通过专业化生产、实施精品战略、走国际化道路打造国际品牌,进而提升格力产品价格、获取规模经济效益、吸引优秀人才、占领国际市场并实现供需双赢,最终使格力电器成功实现了迄今为止、全球首个依靠单一品类突破千亿元的家电品牌,从而保持了格力电器在全球家电产业中的霸主地位,让"中国制造"再次领跑在全球家电行业的最前列。     

论我国视频警务的现状与完善

随着公安视频监控建设飞速发展,以充分发挥视频图像信息效能为核心的视频警务模式已悄然兴起。当前,视频警务在视频监控系统建设、视频图像分析技术等方面存在诸多问题,但最为核心的还是体制和机制方面的问题,表现为缺少系统化的工作体制,缺少规范化的工作流程。因此,应从视频图像信息的获取、分析、应用环节构建视频警务工作体系,科学设计视频的采集报送、分析研判、运行和保障的工作机制,进一步完善视频警务工作。     

CT‐Guided,Minimally Invasive,Postmortem Needle Biopsy Using the B‐Rob II Needle‐Positioning Robot

CT‐guided, minimally invasive needle biopsy techniques can be used to retrieve tissue or body fluid samples for histologic tissue diagnoses in forensic investigations. The purpose of this study was an evaluation of CT‐guided needle‐positioning robot B‐Rob II. To operate under CT guidance, we adopted the B‐Rob II robotic needle placement system and its workflow. The accuracy and speed of the procedure were tested on a gelatin phantom in a series of 21 biopsies. We achieved an average needle placement accuracy of 1.8 mm (±1.1 mm) using robotic assistance. The procedure required an average of 2 min 21 s. The needle placement accuracy for minimally invasive needle biopsies using the B‐Rob II biopsy robot is sufficiently accurate and fast for forensic postmortem examinations of focal organ changes. Further tests will be performed to test the feasibility of the robot for performing biopsies of focal organ changes in human bodies.     

Identification Method for Digital Image Forgery and Filtering Region through Interpolation

Because of the rapidly increasing use of digital composite images, recent studies have identified digital forgery and filtering regions. This research has shown that interpolation, which is used to edit digital images, is an effective way to analyze digital images for composite regions. Interpolation is widely used to adjust the size of the image of a composite target, making the composite image seem natural by rotating or deforming. As a result, many algorithms have been developed to identify composite regions by detecting a trace of interpolation. However, many limitations have been found in detection maps developed to identify composite regions. In this study, we analyze the pixel patterns of noninterpolation and interpolation regions. We propose a detection map algorithm to separate the two regions. To identify composite regions, we have developed an improved algorithm using minimum filer, Laplacian operation and maximum filters. Finally, filtering regions that used the interpolation operation are analyzed using the proposed algorithm.     

The Possibilities and Limitations of Forensic Hand Comparison

On recordings of certain crimes, the face is not always shown. In such cases, hands can offer a solution, if they are completely visible. An important aspect of this study was to develop a method for hand comparison. The research method was based on the morphology, anthropometry, and biometry of hands. A new aspect of this study was that a manual and automated test were applied, which, respectively, assess many features and provide identification rates quickly. An important observation was that good quality images can provide sufficient hand details. The most distinctive features were the length/width ratio, the palm line pattern and the quantity of highly distinctive features present, and how they are distributed. The results indicate that experience did not improve the identification rates, while the manual test did. Intra‐observer variability did not influence the results, whereas hands of relatives were frequently misjudged. Both tests provided high identification rates.     

Strategies moulding brand reputation building in the early 21st century

Abstract

Since the mid-1990s, the changing political, economic and social environment and globalisation have contributed to change business behaviour in South Africa. Nowadays, business strategies are built alongside sustainable business goals, with renewed emphasis on quality and brand reputation management. Business intelligence (BI) systems and research demand show clear emphasis on customer brand franchising and brand citizenship in particular. Brands are no longer used only as marketing communication tools. Nowadays, brand companies seem well aware of stakeholders’ concerns with non-financial business aspects and are responding through re-branding, improved customer relations and good corporate citizenship behaviour. Consequently, direct customer feedback via customer satisfaction and franchise-building research, as well as corporate citizenship image and perception surveys have emerged as key research tools that generate business intelligence used to build and protect company reputation. The way in which contemporary research designs are constructed to guide reputation building and protection, and how these inputs are used to guide business reputation strategies form the core of this article. The discussion reveals that corporate reputation and brand management functions are increasingly being synchronised in support of customer-based brand equity, customer franchise and reputation building. This suggests substantial communality between the management functions relating to corporate reputation and branding. Corporate branding and reputation are anticipated to evolve as a core business strategy aimed at building and protecting corporate identity and image. To meet this endeavour, companies will continue to brand their identity and image and create brand awareness and customer relations to enable stakeholders to differentiate company products, services and features from competitor offerings, but will simultaneously strive to enhance customer loyalty. Customer care and ethical behaviour will probably lead the thrust in creating positive corporate reputation. As long as corporate reputation building and branding are pursued, the demand for business intelligence information related to these topics will remain a priority and will guide future marketing and communication strategies in building and protecting corporate reputation.