健康成年人身高全基因组关联及遗传性缺失研究进展

人类身高是由基因与环境等因素共同决定的多基因遗传性状,其遗传率高达80%以上。迄今为止已经发现了一定数量的人类身高相关基因,尤其是全基因组关联分析方法的出现及成功应用,大大加速了这一进程。然而,已发现的SNPs位点仅能解释小部分身高基因变异。本文综述了目前国内外健康成人身高全基因组关联及遗传性缺失研究进展。     

Open Doors and Closed Ceilings: Gender-Based Patterns and Attitudes in the International Studies Association

In 1995, the Gender Research Committee of the International Studies Association conducted a survey of the membership concerning the impact of gender on members' lives. In 2006, the Women's Caucus for International Studies sponsored a follow-up survey utilizing similar questions. A comparison of the findings of the two studies shows increased representation of women within international studies, persistent frustration with the slow pace of progress in women's access to senior positions and in accommodating family issues, some evidence of a chilly climate for women and a leaky pipeline, and significant differences between men's and women's perceptions of the status of women in the profession. The 2006 survey reveals a marked increase in concerns regarding the tension between women's family responsibilities and the academic environment, identification of structural discrimination, and concerns that men have been disadvantaged by affirmative action for women.     

Surveying International Studies Programs: Where Do We Stand?

International studies (IS) programs have proliferated across campuses over the past decades. Given the increasing ubiquity of IS education, as well as the interdisciplinary nature of IS, most previous scholarship on IS programs has focused on issues of curricular structure. Yet there is a lack of systematic information on many key issues facing IS programs. Through a survey of directors of these programs, this study seeks to examine some of the broader issues surrounding IS as a field of undergraduate study. In particular, I examine student popularity of our programs, the various ways in which they are administratively structured, and the perceived stature of IS programs within home institutions. Additionally, some of the factors that contribute to growth in IS programs are examined. The overall goal of this study is to provide a "first step" towards building a comparative assessment and benchmark of the institutional and administrative characteristics of IS programs.     

Electoral outcomes and satisfaction with democracy: A comparison of regional and national elections

Subnational governments have become more numerous and more powerful around the world, increasing the importance of subnational elections. However, we still know little about the impact of regional electoral outcomes on citizens' political support, and there is no systematic comparison of the impact of election outcomes on citizens' satisfaction with democracy. In this research note, we provide such a comparison by investigating how the winner-loser gap in citizens’ satisfaction with democracy differs across regional and national elections. Using data from Canada, Germany and Spain, we first show that there is a winner-loser gap in satisfaction with democracy following regional elections. The winner-loser gap at the regional level is, however, substantially smaller than the one generated by national election outcomes. Next, we find heterogeneous effects for voters who believe that the regional government strongly influences their quality of life. We conclude by discussing the implications of our findings.     

论《乐府指迷》的理论特质

沈义父的《乐府指迷》是产生于南宋后期的一部重要词学论著,影响甚广。其指迷所向,主要是为了抵制两宋时期北曲对宋词的市井俚俗化影响,坚持词学的本色特征,坚持雅词的传统,所以在理论上提出了雅词四标准等一系列主张,并且通过清真词作为雅词样板,将词与曲、诗在音律、字面、表达等方面加以区别,从而显示了词学的独特品格及其理论特质。研究《乐府指迷》与《词源》的相异点,不但可以澄清词学本色论与词曲合一论的不同立场,而且也可更清晰地把握《乐府指迷》的理论特质。     

Drawing conclusions about causes from systematic reviews of risk factors: The Cambridge Quality Checklists

Systematic reviews summarize evidence about the effects of social interventions on crime, health, education, and social welfare. Social scientists should also use systematic reviews to study risk factors, which are naturally occurring predictors of these outcomes. To do this, the quality of risk factor research needs to be evaluated. This paper presents three new methodological quality checklists to identify high-quality risk factor research. They are designed so that reviewers can separately summarize the best evidence about correlates, risk factors, and causal risk factors. Studies need appropriate samples and measures to draw valid conclusions about correlates. Studies need prospective longitudinal data to draw valid conclusions about risk factors. And, in the absence of experimental evidence, controlled studies need to compare changes in risk factors over time with changes in outcomes to draw valid conclusions about causal risk factors.

存在决定意识基础上对学术和政治统一性的关注——高校师生思想变化特点探求

高校师生思想状况的跟踪调查已有多年,研究其变化的规律特点尚待深入。从10年问卷数据看,高校师生对当今中国发展状况高度认可,同时也显现出对个人权益发展空间的更多关注。从整个新时期跨度看,30年中国改革开放的成功实践获国人高度认可,但纷繁的学术思潮对中国的现实存在也有不同诠释,它们构成了高校师生思想变化的肯定否定交响曲。高校师生思想的互动及其与社会的互动,体现出存在决定意识基础上对学术和政治统一性的关注与追求。     

Psychosocial and Symbolic Dimensions of the Breast Explored through a Visual Matrix

This article explores knowledge about the breast in lived experience, addressing a gap in empirical research on a highly gendered cultural trope and embodied organ. We present findings from a study that used a free-associative psychosocial method—the Visual Matrix—in order to stimulate expressions of tacit aspects of the breast, aiming to generate an understanding of relations between embodied and enculturated experiences. Our data revealed how an aesthetic of the grotesque in one matrix allowed the mainly female group to use humour as a “creative psychic defence” against culturally normative and idealized aspects of the breast. This was expressed through symbolizations, affectively delivered in an exuberant mode, emphasizing the breast‘s potency and its potential for nurturance and “weaponization”. Through this feminine poetic, life and death became inseparable yet ambiguous dimensions of breasts. The breast’s life-affirming qualities included the sensual, the visceral, and the joyful—a material-semiotic knowing. This was incontrast to a second matrix, which expressed a more ambivalent and troubled response, and in which associations were weighted towards the spectacular breast of an ocular-centric culture that privileges hetero-masculine looking. We discuss differences between the two matrices in terms of psychosocial tensions between embodied and enculturated experiences.     

From Lab Experiments to Real Negotiations: An Investigation of International Iron Ore Negotiations

Negotiation researchers have conducted a large number of experimental lab studies to identify the factors that affect negotiation outcomes, but it remains unclear whether those results can be generalized to real‐world negotiations. To explore this question, we analyzed the dynamic international iron ore annual negotiations that took place from 2005 to 2009. We found evidence that supports two important findings from previous experiments. Specifically, we focused on the impact of negotiators’ best alternatives and first offers on negotiation prices using multiple case study analysis. We found that iron ore prices increased more when the gap between the previous year's negotiated price and the price on the alternative spot market, a public market in which commodities are traded for immediate delivery, was larger, which suggested that buyers were sensitive to the strength of this alternative, supporting the literature on the role of alternatives. We also found that the first offer price significantly influenced the final price. Our findings extend two important experimental findings from the negotiation literature to large‐scale business negotiations in the real world.     

Defensive semiotic strategies in government: a multimodal study of blame avoidance

In this article, I argue that when officeholders try to avoid blame, they often engage in defensive performances which can be analysed in terms of how they exploit various multimodal semiotic resources to ward off (potential) criticism: the setting, appearance, and manner chosen for a particular interaction with an audience; and both verbal and non-verbal ways of arguing, legitimising, framing, and representing social actors and actions. I apply these analytic categories to interpret the data gathered during fieldwork at a major training event of British government communicators. By combining insights from multimodal discourse analysis, discourse-historical studies of organisational behaviour, and recent research into blame avoidance in public administration, I demonstrate how certain semiotic strategies used by officeholders have an effect of backgrounding the ideas about any possible norm violations that government communicators may have been associated with in the eyes of critical audiences, such as lying, spin doctoring, and using tax money for propaganda campaigns that may not actually serve the interests of the public. I suggest that analysts of government communication should pay more attention to the defensive practices of government insiders, and study in great detail how these practices are incorporated into everyday behaviour through professional training.