Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC

This paper describes two analytical techniques used to separate and quantify gamma-hydroxybutyrate (GHB) and gamma-hydroxyvalerate (GHV). The first technique was a N,O-bis(trimethylsilyl)triflouro-acetimide-trimethylchlorosilane derivatization, followed by gas chromatography/mass spectrometry analysis using an HP-5 capillary column at a rate of 1.0 mL/min with a run time of 9.25 min. This technique was found to be sensitive (LOD 1 pg on column) and gave a low average error (5%) in a beverage study. When supplemented by a surrogate spike, the method yielded 97% analyte recovery from beverages. The second technique was high-performance liquid chromatography/UV (HPLC/UV) using a C-18 column with a (20:80% v/v) methanol:dibasic phosphoric buffer (10 mM, pH 3) at a rate of 1.00 mL/min with a run time of 7.5 min. UV detection occurred at 254 nm. This method was found to be less sensitive (LOD 0.05 microg on column) for direct analysis of aqueous samples. To remove interferences seen in the beverage study, a liquid-liquid extraction before HPLC analysis was tested. However, a decreased sensitivity (LOD 100 microg on column) and irreproducible peak profiles resulted.     

思想政治教育主体间性问题研究

在改革开放不断深入的时代背景下,传统思想政治教育主客二分模式的内在缺陷日益彰显,强烈呼唤思想政治教育哲学方法论的创新,主体间性理论的引入,使思想政治教育改革发展步入了一个新境界,必将大力提升其科学性、实效性。     

Where Size Matters: Agglomeration Economies of Illegal Drug Markets in Philadelphia

There is a debate over whether police attention focused on an illegal drug market causes dealers to spatially displace their activities “around the corner” therefore having no positive impact on the aggregate level of illegal drug sales in the city. The alternative perspective is that focused police attention lowers the rate of illegal drug sales in the city. Recent research in Jersey City, New Jersey has demonstrated that focused police attention does not simply move illegal drug dealing around the corner. The present analysis explains why this finding is likely to be common in other cities using the economic theory of “agglomeration economies.” Agglomeration economies illustrate that taking the largest and most profitable site from illegal drug dealers will make dealing in the surrounding neighborhoods less rather than more profitable and lead to a smaller marketplace overall. The empirical analysis focuses on Philadelphia, Pennsylvania.     

PROSPECT lost: when a pilot project does not look to learn

If a development project is destined to reach only a selection of its intended beneficiaries or to give them only momentary or uncertain benefits, there is a strong rationale for making it instead a project of trials from which lessons can be taken for obtaining the impact that it may not otherwise have. Because the fundamental problems and opportunities of development are very complex by their nature, interventions that seek to test practice knowledge and to learn above all else may have the greatest potential for benefit in the long term. A project that wishes to create experience from which others can learn will engage in research, so it must be conceived, led and conducted as such. This means it must be designed with knowledge of research. It must be led with an appreciation and understanding of research method. Specific research activities must be conducted that produce knowledge and promote its up‐take, so that learning is a principle project outcome. The large urban anti‐poverty project, PROSPECT, conducted in Lusaka, Zambia, illustrates this argument. Copyright © 2008 John Wiley & Sons, Ltd.     

Quantitative Analysis of Sildenafil and Tadalafil in Various Fake Drugs Recently Distributed in Korea

Abstract: Illicit distribution of various illicit or counterfeit drugs containing sildenafil and tadalafil has increased and caused noticeable problems in Korea. This study has been performed to determine the content range of sildenafil and tadalafil in various fake drugs. Among the illicit or counterfeit drugs seized by Korean authorities, 105 exhibits were used for the quantification. HPLC–UV analysis of methanol extractions was used for separation and quantitation of the two target compounds. The most abundant type of fake drug was counterfeit Viagra^® tablets. Sildenafil was found in 73 exhibits, and tadalafil was found in seven exhibits. Twenty‐five exhibits out of the 105 contained both sildenafil and tadalafil. The contents of sildenafil ranged from 4.3 to 453.2 mg; for tadalafil, the range was 2.2–40.4 mg. The proportion of cases of having more than 100 mg of sildenafil was 50% and 78% had more than 20 mg of tadalafil.     

A METHODOLOGICAL ADDITION TO THE CROSS‐NATIONAL EMPIRICAL LITERATURE ON SOCIAL STRUCTURE AND HOMICIDE: A FIRST TEST OF THE POVERTY‐HOMICIDE THESIS*

Dozens of cross‐national studies of homicide have been published in the last three decades. Although nearly all these studies test for an association between inequality and homicide, no studies test for a poverty—homicide association. This absence is disconcerting given that poverty is one of the most consistent predictors of area homicide rates in the abundant empirical literature on social structure and homicide in the United States. Using a sample that coincides closely with similar recent studies, applying a proxy for poverty (infant mortality) that is commonly employed in noncriminological cross‐national research, and controlling for several common covariates (including inequality), this study provides the first test of the poverty—homicide hypothesis at the cross‐national level. The results reveal a positive and significant association between a nation's level of poverty and its homicide rate. The findings also suggest that we may need to reassess the strong conclusions about an inequality—homicide association drawn from prior studies, as this relationship disappears when poverty is included in the model.     

我国《海商法》承运人迟延交付确定标准之不足

分析国际公约、国外立法例和中国法律关于迟延交付的规定,指出中国《海商法》关于承运人迟延交付仅规定"约定时间"标准之不足,提出在《海商法》迟延交付中引入"合理时间"标准的修改建议。     

Reducing Homicide through a “Lever‐Pulling” Strategy

The decade of the 1990s witnessed unexpected but welcome large declines in homicide and serious firearms violence. Yet, despite these declines, rates of firearms crime in the United States remain high compared to other western democracies and impose significant costs to society generally and to specific communities particularly. One promising approach to gun crime emerged in Boston during the mid‐1990s. This approach combined face‐to‐face communication of a deterrence message to youth gang members with social service outreach and crackdowns on several gangs. Boston then experienced very significant declines in youth gun crime. This approach was later repeated in Minneapolis with similar promising results. This paper presents the results of a study of a similar gun‐crime‐reduction effort in Indianapolis. Time‐series analyses suggest a significant decline in homicide similar to those observed in Boston and Minneapolis. Comparisons to six similar Midwestern cities revealed that Indianapolis was the only city to experience a significant decline in homicide. The results are discussed in the context of deterrence research and suggest the need to move beyond single‐city evaluations of promising interventions.     

PROTECTING CHILDREN'S RIGHTS IN CONTACT DISPUTES: THE ROLE OF CHILDREN'S CONTACT SERVICES IN AUSTRALIA*

This article explores the role of Children's Contact Services (CCSs) in protecting children's right to express, and have heard, their wishes in contact disputes. The findings presented are drawn from the Australian Children's Contact Services Project and were based on 142 interviews with representatives from the government, the courts and legal profession who refer families to CCSs, service staff, as well as the parents and children who use the services. An analysis of client data from 396 families who had used one of six contact services in Victoria and Queensland during the month of August 2003 was also conducted. The findings suggested that CCSs successfully engaged children in a “dynamic self‐deterministic” process where children were able to explore their own wishes in relation to contact visits over time as their relationship goals changed. John Eekelaar described this process as being central to making decisions that are in children's best interests.     

明郑台湾天兴万年二县（州）辖境的再探讨

明郑时期，台湾分为天兴、万年二县（州）。这两个县（州）的辖境如何划分，当时并无明确的记载。有的学者认为，天兴县（州）所管辖的地域就是清初诸罗县的地域，万年县（州）的地域清初则分为台湾县和凤山县。有的学者则认为，万年所管辖的地域即为清初的凤山县，天兴的地域清初则分为台湾和诸罗二县。本文通过论证，提出了新的观点，认为天兴县（州）的辖境，包含了清初诸罗县的全部和台湾县的一部分，万年县（州）的辖境则包含了清初凤山县的全部和台湾县的另一部分，并对天兴、万年的分界线走向提出了看法。