川芎嗪微乳的脑靶向性研究

[摘要]目的 制备川芎嗪微乳,初步考察其在小鼠体内的脑靶向性。方法 分别给小鼠口服川芎嗪微乳和川芎嗪片剂混悬液,在给药后不同时点分别观察并比较小鼠脑部川芎嗪的血药浓度。结果 川芎嗪微乳总靶向效率(overall targeting efficiency,TE)=18.75%,川芎嗪片剂混悬液TE=12.25%;靶向指数(targeting index,TI)=606.00%,相对靶向效率(relative overall targeting efficiency,RTE)=53.06%。结论 小鼠口服川芎嗪微乳后,川芎嗪在脑部的含量明显高于小鼠口服川芎嗪片剂混悬液后脑部川芎嗪含量,且川芎嗪在脑部平均滞留时间(mean residence time,MRT)也明显延长,说明川芎嗪微乳具有脑靶向性和缓释性。     

通货膨胀目标制的内涵及在中国的检验

通货膨胀目标制是当今世界流行的一种货币政策制度.尽管学术界至今对通货膨胀目标制存在不同意见,但对这一制度的有关特征是有共识的,即要明确规定一个数量化的通货膨胀目标;货币政策操作应该有相当高的透明度;中央银行对通货膨胀目标的实现承担责任.此外,通货膨胀目标制是一个包括操作工具、操作目标、信息变量和最终目标在内的有关货币政策制定和实施的系统.本文构建了这一制度的模型框架,并用中国的数据检验了其适用性.结果表明,灵活通胀目标制规则在当前中国的货币政策实践中并不非常适合.     

转型期的中国货币政策规则：基于拟合效果的选择

从拟合效果的角度来分析通货膨胀目标制和泰勒规则这两大最流行的货币政策规则在中国的选择问题,研究结果表明,从对中国利率走势的预测能力来看,通货膨胀目标制远远优于泰勒规则.因此,中国人民银行要想提高对宏观经济的把握能力,及时准确地获取宏观经济信息,应该选择通货膨胀目标制并积极创造实行通胀目标制的各种条件.     

Mis-marketing the Conservatives: The Limitations of Style over Substance

Every Tory leader since 1997 has made significant attempts to use marketing; the most recent, Michael Howard, appointed the first ever UK party Marketing Director to head a specialised Marketing Department. However, whilst the Conservatives have made use of the tools of marketing (polling, focus groups, public listening exercises, communication) they have misunderstood the concept of political marketing, which is concerned with creating a unified political product that is responsive to voter demands. Political marketing has hitherto not worked for the Conservative party. This is because there is a lack of a supportive internal culture that accepts the party change necessary to produce a market-orientated political product including policy, leadership and candidates. If political marketing is only used to sell a product that the party elite rather than the British public wants, it will never help the Conservatives regain control of government.     

Why Solidarity Matters: The Political Strategy of Welfare Design

Reporting on our recent book, The Solidarity Society, this article explores the way in which the design of welfare programmes interacts with and shapes the underlying quality of social relations between members of society—and, through this, public attitudes to welfare. Given that sustaining generous welfare over long timescales requires the support of electorates, this ‘relational’ dimension of welfare policy is crucial for the long‐term strategy of tackling poverty and inequality. The article looks in particular at the ‘welfare dilemmas’ that can arise from tensions between targeting and universalism and between need and entitlement, where the distributional and relational elements of welfare policy work against one another. We conclude that entrenching a generous welfare settlement will require strong elements of both universalism and reciprocity in the design of welfare.     

When Terrorism Goes to Sea: Terrorist Organizations and the Move to Maritime Targets

Terrorist groups are often relatively conservative in their choice of strategy, tactics, and targets, and it is worth asking what characteristics are associated with unconventional behavior. In this article we explore the question of why terrorist organizations move to one type of unconventional attack that has been a focus of concern of policymakers in recent years, namely attacks on maritime targets. Through an investigation of the organizational capacity and ideology of terrorist groups that committed maritime attacks between 1998 and 2005, we argue that this kind of violent behavior is driven by capability. Certain organizational characteristics of terrorist groups—territorial control, involvement in the drug trade, organizational size, and connections with other groups—provide groups with the capabilities that make maritime attacks both realistic and desirable. Terrorist groups' ideology—what they believe, and what their goals are—does not have the same impact, with the possible exception of groups affiliated with al-Qaeda. Our findings have implications for future research.     

Crime Scene and Distance Correlates of Serial Rape

This study, derived from a sample of 108 serial rapists (rapes=565), examines the relationship between demographic, crime scene, and criminal history variables and the distance traveled by serial rapists in order to offend. The pattern of offenses perpetrated by each of the 108 serial offenders as it relates to his place of residence is also analyzed in terms of known characteristics of the offender and his offenses. The theoretical focus of the study integrates premises derived from criminal investigative analysis, environmental criminology, ethnographic geography, journey to crime research, and criminal geographic targeting to explore the cognitive symmetry between the how and the where of serial sexual offenses. These components or dimensions of serial crime are explored in an attempt to aid law enforcement in their investigation of hard-to-solve serial crimes.     

Inflation targeting at the crossroads: Evidence from post-communist economies during the crisis

The objective of this paper is to assess if inflation targeting post-communist economies performed better, in terms of output growth, during the crisis than their non-inflation targeting counterparts. The paper also puts the issue in the context of the preconditions of inflation targeters to adopt this regime. 26 post-communist economies of Central and Eastern Europe and the Commonwealth of Independent States are analyzed during the ongoing economic crisis. Results suggest that inflation targeters of those countries performed worse than non-inflation targeters. The growth decline in inflation targeters post-communist economies has been estimated to be deeper by about four percentage points than that in non-inflation targeters. The study finds very limited role of the preconditions for growth decline. Only the lower amount of monetary financing of the budget may have contributed in inflation-targeting countries to have gone through the crisis better.     

Analysis on the Policy Effects of Strict Inflation and Flexible Inflation in Interest Rate Liberalization

This paper analyzes the policy effects of interest rate liberalization under strict inflation targeting and flexible inflation targeting, which is based on the new theory of Keynes model and the introduction of price stickiness in the framework of dynamic stochastic general equilibrium. By building, calibrating, estimating and simulating a new Keynesian DSGE model, we analyze and compare the effect of strict inflation targeting and flexible inflation targeting in the process of the interest rate liberalization. Research results show that, first of all, the strict inflation targeting regulation makes the output volatility smaller and the inflation volatility greater in face of technology shocks. Secondly, the flexible inflation target system is more conducive to controlling output and inflation in the short period when facing monetary policy shocks. Finally, the control of the strict inflation target is less from the point of view of the loss function. In other words, the central bank's loss function under the control of the strict inflation target system is small, but the flexible inflation targeting system is more conducive to controlling output and inflation in the short period.     

Source Strategies and Media Audiences

ABSTRACT

This article argues for a particular approach to the relationship between the production and reception of mass media, using as a key the theory of targeting and its application in elements of the political marketing mix: media relations and news management. In particular, two case studies show that in this context very fine-tuned targeting is normal and that the details of conjuncture are crucial. The implications of this form of targeting for the understanding of media audiences are spelt out through a critique of certain approaches to the audience: audience measurement, agenda-setting and framing theory, ‘active audience’ theories, and targeting as practised in media buying and programming. On the basis of these case studies and critiques, it suggests that this category of targeted audiences has characteristics whose relevance to analysis of the production/reception relationship has gone unrecognised, and that to this extent the theory of this relationship needs to be re-cast.