黄芪建中汤对胃黏膜损伤模型大鼠MMP-9、TIMP-2表达的影响

目的 观察黄芪建中汤对胃黏膜损伤模型大鼠基质金属蛋白酶-9(matrix metalloproteinase 9, MMP-9)及基质金属蛋白酶组织抑制剂-2(tissue inhibitors of matrix metalloproteinase 2,TIMP-2)表达水平的影响. 方法 将健康SD大鼠随机分为4组:假手术组、模型组、雷尼替丁组和黄芪建中汤组,每组10只.采用改良Okabe法复制动物模型.胃黏膜MMP-9、TIMP-2表达水平检测采用免疫组织化学法. 结果 模型组MMP-9表达较假手术组显著升高(P<0.01),各治疗组MMP-9表达水平显著低于模型组(P<0.01);模型组TIMP-2表达水平较假手术组显著降低(P<0.01),各治疗组TIMP-2表达水平显著高于模型组(P<0.01),黄芪建中汤组较雷尼替丁组TIMP-2表达水平显著升高(P<0.01). 结论 黄芪建中汤通过调控MMP-9、TIMP-2的表达水平,修复胃黏膜损伤.     

毫米波照射肾俞穴对家兔肾血流量的影响

In this Paper, the low Power milimeter wave ( MMW ) was employed to irradiate the rabbit on "Shenshu" point and on the surface of kidney, and the renal blood flow ( RBF ) before and after irradiation were measured by means of hydragon gas clearance method. The results show that RBF of both normal rabbit and that with acute renal blood deficiency are significantly increased after irradiating "Shenshu" Point (P<0.05); and compared with the rabbit whose kidney surface was irradiated, the RBF before and after irradiation have no significant difference (P>0.05); and that the RBF is increased more in the rabbit whose renal nerve was excised than in rabbit whose renal nerve was intact; there is a significant difference between them (P<0.05). The results of this paper suggest the effect of MMW irradiating "Shenshu" Point be similar to that of MMW irradiating the kidney surface, and as a new invulnarable specific therapy on points, MMW have a latent value in clinics.     

镇静安神汤治疗非感染性尿道综合征66例

非感染性尿道综合征是临床常见病。近年来我们用镇静安神汤治疗本病66例,疗效较满意,现报告如下。1　临床资料66例均系门诊,其中男38例,女28例;年龄12～58岁,以19～34岁最多,病程最短3Ｗ,最长5年。全部病例膀胱激惹征持续3Ｗ以上,尿频尤为突出,且每次尿量不多,常伴有尿急?..     

解毒活血化瘀汤治疗淤胆型肝炎67例

1　临床资料全部病例系我院近年住院病人,符合1995年5月北京第5次全国传染病与寄生虫病学术会议制定标准〔1〕。治疗组67例,男55例,女12例;年龄17～63岁。血清总胆红素(ＴＢ)110～170μｍｏｌ/Ｌ者18例,171～300μｍｏｌ/Ｌ者44例,>300μｍｏｌ/Ｌ者5例;血清谷丙转氨酶(Ａ...     

芪藤消浊颗粒治疗脾肾亏虚血瘀型IgA肾病临床研究

目的 观察芪藤消浊颗粒治疗IgA肾病脾肾亏虚血瘀证患者的临床疗效及对患者血清转化生长因子β1(transforming growth factor-β1,TGF-β1)、结缔组织生长因子(connective tissue growth factor, CTGF)、血管内皮生长因子(vascular endothelial growth factor, VEGF)、内皮素-1(endothelin-1,ET-1)水平的影响。方法 选择64例IgA肾病脾肾亏虚血瘀证患者随机分成对照组和观察组,每组32例,共4例患者退出观察,实际每组完成30例。对照组口服缬沙坦治疗,观察组在对照组基础上加服芪藤消浊颗粒,疗程共12周。观察治疗前后两组患者中医证候积分和临床疗效,检测治疗前后24 h尿蛋白(24-hour urine protein, 24hUP)、尿红细胞(urinary red blood cell, URBC)计数、血清白蛋白(albumin, Alb)、TGF-β1、CTGF、VEGF和ET-1水平,并根据血清肌酐值计算肾小球滤过率(estimated glomerular filt...