UPLC-MS/MS法检测佐匹克隆及其在大鼠体内动态分布研究

目的建立安眠镇静药佐匹克隆的检测方法及其在大鼠体内动态分布模型。方法实验组大鼠用佐匹克隆橄榄油溶液(47.25mg/kg)灌胃给药,空白对照组大鼠采用橄榄油灌胃,分别于0.5、1、1.5、2.5、5、8、12h后采集心血后处死大鼠,分别取心、肝、肺、脾、肾、胃、大脑组织,采用超高效液相色谱-串联质谱法(UPLC-MS/MS)检测各组织中佐匹克隆的质量浓度。结果佐匹克隆与内标物SKF525A出峰时间分别为1.43、1.6min。各组织中佐匹克隆在5~5000ng/mL(g)线性关系良好。佐匹克隆在10、100、1000ng/mL三个浓度下日间、日内精密度良好,在各组织中平均萃取回收率高。灌胃给药后大鼠各组织中佐匹克隆含量在0.5~1h内呈上升趋势,在1h时达到峰值,在各时间点,佐匹克隆在胃壁组织中含量较其他组织高,心血和大脑组织中相对较少。结论本课题建立的UPLCMS/MS法动态检测大鼠各组织中佐匹克隆的含量具有高效性、可靠性的特点,这对今后法医学案件中涉及到佐匹克隆定性定量检验有一定的参考价值。     

贵州地方政府依法行政动力研究

经过近十年的努力,依法行政有了明显进展,但在外部要求依法行政呼声日益高涨的今天,推进依法行政工作还存在一些不容忽视的问题,那就是政府自身依法行政的动力明显不足,主要表现在推进依法行政工作进展不平衡,工作力度有自上而下呈现逐级递减的趋势。本文以贵州为例进行分析,试图在查找出阻却贵州地方政府依法行政的原因的基础上进行实践性制度设计,激发地方政府,特别是市、县两级基层政府依法行政动力。*     

30例Wilson病患者动态心电图分析

目的:了解Wilson病(Wilson''s disease,WD)患者的动态心电图异常情况,并分析其发生机制.方法:对30例WD患者的动态心电图特征进行观察分析.结果:WD患者动态心电图主要表现为活动时窦性心动过速(窦速)和休息时窦性心动过缓(窦缓)、偶发房性期前收缩(房早)和室性期前收缩(室早)、房性心动过速、室性心动过速及窦房传导阻滞等,个别心电图异常明显者为病程长且驱铜治疗不正规、神经系统症状严重者.结论:WD患者的动态心电图存在较多异常改变,其发生机制主要为铜在中枢神经系统沉积所致中枢性自主神经功能障碍,铜在心肌沉积所致心肌损害或肝硬化所致代谢性心脏损害.     

社会网络的动态过程及理论探索

本论文关注社会网络研究经常被忽视的一个层面,即社会网络的动态过程。在对相关理论的批判性回顾基础上,提出了一个整合结构、文化与个人能动性的理论框架以全面洞察个人的社会网络在社会文化脉络下的动态变化。     

Persistence of innovation: stylised facts and panel data evidence

This paper investigates whether firms innovate persistently or discontinuously over time using an innovation panel data set on German manufacturing and service firms for the period 1994–2002. It turns out that innovation behaviour is permanent at the firm level to a very large extent. Using a dynamic random effects discrete choice model and a new estimator recently proposed by Wooldridge (2005), I further shed some light on the driving forces for this phenomenon. The econometric results show that past innovation experience is an important determinant for manufacturing as well as for service sector firms, and hence confirm the hypothesis of true state dependence. In addition, the results highlight the important role of knowledge provided by skilled employees and unobserved individual heterogeneity in explaining the persistence of innovation.

Dynamic risk and protective factors

ABSTRACT

This paper reviews the literature regarding the identification and measurement of risk factors considered imminent precipitants of subsequent criminal conduct (i.e. dynamic risk factors). This paper also frames these risk factors against the so-called protective factors that are presumed to mitigate risk. Commonality among recent dynamic risk and protective measures reflects general agreement regarding viable candidate variables. Empirical studies suggest such factors yield incremental predictive validity and should inform case-formulaic understanding of criminal conduct and pathways to desistance, although this is not common practice. As well, definitional and measurement considerations are not well advanced and speak to the need for further conceptual clarity.     

From dynamic risk factors to causal processes: a methodological framework

ABSTRACT

It is becoming increasingly apparent that dynamic risk factors are unable to function as explanations of offending because they are composite constructs, which contain a mixture of putative causes, states of affairs, and problematic cognitive, affective, behavioural and social states associated with crime. In this paper we draw from psychopathology research and theory on the conception and classification of mental disorders to develop the Dynamic Risk Research Framework (DRRF). In our opinion, the assumptions and methodological tool associated with this framework can better focus research into the causes of offending by making use of the information provided by dynamic risk factors. A conceptual framework such as the DRRF can arguably translate this valuable information into deep, coherent explanations, and ultimately, more streamlined and precise intervention strategies.     

论著作权法的范式转换 从“权利”到“行为规制”

现行著作权法条文的构造具有浓厚的自然权理论色彩,重视对著作人身权的保护,且在处理著作财产权时拘泥于物权构造。静态思维的权利范式缺乏体系化思维,将著作权误解为对作品这一无体"物"享有的权利。然而,著作权的本质是行为规制,其对私人行动自由的限制程度较高。因此,著作权法的思维方式也需要从静态思维的权利范式转向动态思维的行为规制范式。动态思维的行为规制范式,既可以纠正政策形成过程中的利益倾斜问题,也可以弥补著作权法条文与使用者普遍认知之间的偏差。     

纳什均衡视角下的规范量刑与自由裁量

规范量刑和自由裁量是刑法理论中一对相互矛盾的范畴,处在此消彼长不断博弈的状态。规范量刑和自由裁量各自的利弊决定两者在博弈中只有构成均衡——纳什均衡,才能相互制约并发挥最大的效用,从而使得人们没有违反量刑规则的激励和动机。同时,随着社会的不断发展变化,这种均衡也是个局部均衡、动态均衡的过程。必须不断进行调整。