HPLC测定脑络通胶囊中盐酸托哌酮的含量

目的:用高效液相色谱法测定脑络通胶囊中盐酸托哌酮的含量。方法:采用ODS C18柱(5μm,4.6 mm×250 mm),乙腈-0.05 mol/L磷酸二氢钾(30∶70)(用磷酸调节pH值至3.0)为流动相,检测波长256 nm,流速为1.0 m l/m in,柱温:室温。结果:盐酸托哌酮在0.204~1.530μg范围内线性关系良好(r=0.999 6),回收率为97.96%,RSD为1.01%(n=5)。结论:该方法能准确、可靠地进行该制剂中盐酸托哌酮的含量测定,能够有效地控制该制剂的质量。     

Microcrystal analysis of cocaine hydrochloride and added adulterants

The objective of this project was to investigate the trends of changes in the crystal morphology of cocaine in the presence of the common adulterants, caffeine and lidocaine HCl. By performing gold chloride microcrystal tests on samples of cocaine with adulterants at 10, 20, and 50% concentrations, trends in the changes of the crystal morphology can be linked to specific adulterants and concentrations. For cocaine/caffeine mixtures, the trend is elongation of one axis, additional branching, and brown discoloration of the crystals. At 50:50 cocaine/caffeine mixtures, branched spherical crystals and long needles appear. The trends for cocaine/lidocaine mixtures include elongation of one axis with an X-shaped middle axis. The axes continue to grow and branching decreases until at 50%, spherical clusters of needles appear. These results indicate microcrystal analysis can be used as a novel method for presumptively identifying not only cocaine but also the identity and concentration of the adulterant.     

麻黄碱的膜法萃取

目的：从麻黄水提液中萃取分离麻黄碱，方法：采用膜分离方法。结果：小于8h麻黄水提液的膜分离液为一无色溶液，经纸层析实验表明该溶液几乎为纯净的麻黄碱溶液，8h以后的分离液是一个三组分溶液，本膜不存在污染问题，结论：膜萃取法可分离出较为纯净的麻黄碱。