Doxepin and nordoxepin concentrations in body fluids and tissues in doxepin associated deaths

Body fluids and tissues in eight doxepin (Dox)-related deaths were investigated in order to prove whether the individual concentration of Dox, the concentration sum of parent drug and its active metabolite N-desmethyldoxepin (NDox) or the concentration ratio Dox/Ndox valuably contribute to making a cause of death determination. Individual case histories were shortly described. Dox and NDox concentrations were determined by LC–MS/MS. Dox concentration measured from two cases was well within a concentration range considered therapeutic, whereas subtherapeutic dosing may have occurred in another two cases. There were two cases of fatal Dox ingestion, as well as a case of high dosage and advanced putrefaction, respectively. The liver concentration sum may be more useful if a fatal ingestion cannot be clearly separated from a person's medication usage. High concentrations could be observed in lung tissue, and combined concentrations of Dox and NDox may also be helpful in making a cause of death determination. There was a trend to a higher concentration sum in the brain with increasing combined levels in blood. Overall, the sum of the absolute figures allows a more accurate interpretation in Dox-related deaths as compared to the molar concentration ratio which may be helpful in acute ingestion. Determination of the N-desmethyl metabolite along with its parent is recommended and analysis should include more than a single specimen.     

论振兴东北老工业基地进程中的地方政府责任

地方政府在振兴东北老工业基地的进程当中起着举足轻重的作用,包括宏观调控地方经济发展、协调社会矛盾、营造有效的市场环境等。只有发挥地方政府的主导作用,使政府主导与市场经济有效结合,才能真正推动东北老工业基地的振兴。因此,必须强化政府责任。     

RCEP之于我国及亚太地区发展意义解构

2020年下半年国内疫情得到有效控制后,我国完成了一系列事关未来国家经济发展的重大举措,其中,签署RCEP无疑是我国自"一带一路"倡议之后践行人类命运共同体价值理念的又一重大行动。RCEP凭借本身巨型的体量、庞大的潜力、丰富的内涵对成员国的发展起到多层面的重要促进作用,虽然形式上RCEP只是一份区域自贸协定,但其意义绝不仅限于商业贸易领域,在更为深层的政治、经济、国际影响力及话语权等层面,RCEP对于我国和亚太地区的发展还具有更多难以估量的推动作用。为推动RCEP的顺利落实,我国要不断加快经济结构调整以及产业优化升级的步伐,以RCEP为契机加速亚太经济一体化进程,同时还要持续深化双边、多边自由贸易和区域合作。     

六部门动态优化模型在吉林老工业基地产业结构优化升级中的运用

产业结构问题是我国当前亟须解决的重大问题,产业结构的优化升级是经济均衡增长的关键。在相关理论方法还不够完善的背景下,构建适合国情的产业结构动态优化的理论与方法,为我国的结构调整提供有价值的参考,将具有深远的理论与实践意义。产业结构动态优化模型体系与吉林省的实证研究相结合,可以发挥区域优势,以科技进步促进产业的结构升级,解决供需结构失衡的深层矛盾。     

产经新闻在广告经营中的地位与作用

产经新闻的独特性体现在:定位于目标人群,追求报道的深度和广度,在新闻宣传中渗透知识的内涵和新闻张力,做到精、专、深、细,深入报道读者所关心的企业发展和社会影响力方面的新闻,增强媒体吸纳广告的渠道和空间。以阜新日报产经新闻的发展历程为例,分析了产经新闻的特点及在广告经营中的地位与作用,结果表明产经新闻能有效提升企业知名度,整合广告经营中的新闻资源,增强媒体在广告市场中的竞争力。     

20世纪90年代以来越南天然橡胶产业政策探析

越南的天然橡胶业近年来发展十分迅速。现今,越南已成为世界第五大橡胶生产国、第四大橡胶出口国。越南的天然橡胶业能有如此不俗的表现,离不开越南政府制定、实施的相关产业政策。总结越南政府天然橡胶产业政策的经验,对于身为世界第四大橡胶生产国与最大橡胶消费国的中国来说具有十分重要的研究和现实意义。     

加快工业结构调整升级 助推工业强省

工业结构的合理与否关系到未来工业经济的可持续发展,将直接影响贵州“工业强省”进程。文章阐述了“十一五”时期以来贵州工业结构的演变趋势特点,深入分析了未来贵州工业结构调整升级面临的问题与困难,提出了加快贵州工业结构调整升级的对策建议。     

后工业社会的文化危机与新宗教回归

在后工业社会中,后现代文化的空幻以及宗教神圣性的失落,导致文化危机和人生意义的迷失,对此,美国社会学家丹尼尔·贝尔全面探查西方社会结构、政治模式和文化思想领域,尤其对文化在造成当代社会规范、共识崩溃过程中所起的作用,提出了发人深省的反思,主张建立“新宗教”以拯救现代性,这在一定意义上也是对宗教世俗化的走向作了颇具合理性的预测。     

区域优势与贵州民族地区经济发展

本文通过对黄州地区经济发展现状的分析,强调区域的发展必须根据各地区自身的优势和特色来发展,把贫困地区的潜在优势变为经济优势。在保护生态环境的前提下,合理地利用各种资源,利用贵州原有的基础工业,使贵州经济得以持续发展。     

‘Trouble at the gates’: Italian base workers and foreign relations at Camp Darby, 1968-1971

ABSTRACT

From 1968 to 1971, close to a thousand Italian civilian employees at the United States (U.S.) military base, Camp Darby, located in Tuscany faced a series of recurrent layoffs from the U.S. Department of Defence. In a determined effort to protect their jobs, the base workers launched a series of disruptive and persistent forms of protest and civil disobedience that played on the instability of the Italian government and threatened to unsettle the relations between Italy and the United States. Drawing on original archival material from both countries, including large numbers of Italian-language sources, this article provides the first detailed examination of the labor dispute at Camp Darby. I will argue that the base workers secured the intervention of politicians, diplomats, and the Prime Minister in the resolution of the labor dispute by asserting the political significance of their cause both domestically and internationally. The result, I argue, was foreign relations shaped by the agency and often, individual agenda of the non-American workforce at Camp Darby. The dispute points to the complex encounters at play on U.S. military bases abroad as American foreign relations are faced with the convergence of radical labor traditions with Italian domestic politics, and U.S. labor expectations.