大鼠皮肤切创愈合过程中ICAM-1及P选择素的表达

目的　探讨细胞间粘附分子 1(ICAM 1)及P选择素的表达变化与损伤时间的关系。方法　应用免疫组织化学技术 ,对实验大鼠不同损伤时间的生前伤 ( 5min～ 7d)及死后伤 ( 5～ 3 0min)皮肤组织中ICAM 1及P选择素的表达变化进行观察。结果　在生前损伤组中 ,ICAM 1最早在伤后 1h ,最迟至伤后 3d在表皮层中呈阳性表达 ;P选择素最早在伤后 10min ,最迟至伤后 5h即在血管内皮细胞中呈阳性表达。此外 ,ICAM 1还在炎症细胞及纤维母细胞中表达 ,且随损伤时间变化而呈规律性变化。在时间段分组 ,ICAM 1在第Ⅰ组 ( 5min～ 1h)中阳性细胞率极低( 0 41± 0 73 % ) ,第Ⅱ组 ( 3h～ 7h)及第Ⅲ组 ( 9h～ 12h)均呈显著性增高 ( 9 79± 3 74% ,2 3 3 3± 1 10 % ) ,至第Ⅳ组 ( 1d)达高峰 ( 3 0 5 8± 2 65 % ) ,其后逐渐减少。ICAM 1及P选择素在死后伤中均呈阴性表达。结论　ICAM 1及P选择素可作为法医学损伤时间判定的有效指标。     

Self-Silencing and Rejection Sensitivity in Adolescent Romantic Relationships

This study examined the link between rejection sensitivity, self-silencing behaviors, and depressive symptomatology among adolescent dating couples. Self-silencing was hypothesized to be the process mediating the association between rejection sensitivity and depressive symptoms. Our sample included 211 couples between 14 and 21 who were dating at least 4 weeks. Results indicated that dating adolescents who were sensitive to rejection reported more depressive symptomatology and higher levels of self-silencing behaviors within their romantic relationship compared to dating adolescents who were not so sensitive to rejection. Self-silencing was identified as a partial mediator of the association between rejection sensitivity and depressive symptomatology among dating adolescents. Clinical implications in light of these findings are discussed.

损伤经过时间的实验研究

作者在全身麻醉及无菌条件下,通过在大白鼠背部皮肤造成的切创创口,于伤后不同时间杀死.每组中1只于处死前8小时注射秋水仙碱以观察核分裂.取损伤处皮肤,经福尔马林固定、石蜡切片、HE染色、Gorden和Sweet染色(网状纤维)、Weigert染色(弹力纤维)、PTAH染色(纤维蛋白)和Van Gieson染色,于显微镜下观察.结果发现创口逐日缩小,但其中24小时创口较12小时创口有所扩大,伤后第6～7日创口呈突击式缩小.通过组织学变化观察,作者对创口收缩现象在判断损伤时间的意义及形成机理作了讨论.     

The effect of choice reversals on blindness for identification decisions

The present study examined blindness for identification decisions from target-present (TP) and target-absent (TA) lineups using a field study methodology. Eighty pedestrians were exposed to a staged theft. Subsequently, they were asked to identify the thief and the victim from separate, simultaneous six-person lineups. Their identification decision concerning the thief lineup was manipulated such that participants’ selections were exchanged with a previously unidentified lineup member (choice exchange) and lineup rejections were turned into identifications (choice reversal). Participants were 7–10 times less likely to detect choice exchanges (66.7%) compared with choice reversals (11.2%). Furthermore, identification accuracy was not a prerequisite for detection. Thus, rejections and particularly selections made from both TP and TA lineups are susceptible to choice blindness. Finally, our study implies that for blindness in eyewitness identification decisions between-category changes (i.e. choice reversals) are easier to detect than within-category changes (i.e. choice exchanges).     

Under the skin of probation: A statewide analysis

This analysis examines the inter- and intra-racial/ethnicity effects of skin tone variations in a sample of probationers across three dependent variables: probation length, successful completion, and revocation due to technical violations. Darker tones were linked to shorter probation terms with the exception of African Americans, among whom no effect was found. Darker tones were also associated with a decreased likelihood of successful probation completion. Conversely, probation success likelihood was higher among light skinned Hispanics. Finally, lighter tones were also associated with increased risks of probation revocation. Importantly, across the analysis any significant effects for Whites dissipated once Hispanics were removed from the analysis. Explanations of the contrary findings are offered drawing from scholarship on normal crimes and racial threat.     

论内地与香港特区间刑事诉讼转移制度的构建

针对同一起跨境犯罪,内地与香港特区在双方根据各自刑事法律均享有刑事管辖权,且均已启动刑事诉讼程序时,可进行区际刑事诉讼转移,即就该案件刑事管辖权的实际行使达成共识,由一方来行使刑事管辖权,对犯罪予以追究,他方承认实际管辖方所做出的刑事判决。在"一国两制"原则的指导下,中国内地与香港特区间开展刑事诉讼转移的刑事司法合作活动,须遵循"双重犯罪原则"、"有限的犯罪地管辖原则"和"一事不二审原则"。内地与香港特区刑事诉讼转移制度的构建,可以从包括原则、条件、程序和刑事诉讼转移的拒绝4个方面入手予以考虑。     

城市安全不能承受之重与流动人口不能承受之轻——兼论北京市流动人口犯罪预警机制的作用与完善

构建流动人口权益保障体制对于维护城市安全具有重要作用。本文分析了北京市流动人口犯罪的现状与原因,强调理性对待流动人口犯罪的必要性,提出应平等对待流动人口、在控制人口盲目流动的同时应当保障流动人口的基本权益,并发挥犯罪预警机制在预防流动人口犯罪中的作用。     

小鼠皮肤损伤后时序芯片数据分析及关键基因的筛选

目的 应用生物信息学方法对皮肤损伤后不同时间点的差异表达基因(differentially expressed genes,DEGs)进行分析,为法医学皮肤损伤时间推断(wound age estimation)提供理论依据.方法 从基因表达综合数据库(gene expression omnibus,GEO)下载基因芯...     

小鼠皮肤切创愈合过程中caspase-6、-7表达的免疫组织化学研究

目的　观察皮肤切创损伤愈合过程中 ,caspase 6、 7在损伤周边区内的表达及其变化规律。方法　应用免疫组织化学技术观察伤后不同时间小鼠皮肤切创组织中caspase 6、 7的表达 ,以非切创小鼠皮肤组织作对照。 结果　伤后 6h的损伤皮肤组织中可见少量多核粒细胞表达caspase 6、 7,伤后 12～ 2 4h ,大部分浸润的多核粒细胞及部分单核细胞为caspase 6、 7阳性。随伤后时间延长 ,caspase 6、 7阳性细胞以单核细胞及成纤维细胞为主。伤后 0～ 3h ,caspase 6、 7阳性细胞比率较低 ,12h后逐渐增加 ,伤后 3d达高峰 ,其后逐渐下降。 结论　小鼠皮肤损伤愈合过程中 ,caspase 6、 7在损伤周边区内中性粒细胞 ,单核细胞及成纤维细胞中表达 ,其时序性变化规律可望用于皮肤损伤时间的推断。     

Caspase与皮肤损伤

Caspase家族,目前已知至少由14个成员组成,该家族成员在细胞凋亡过程中发挥着重要作用。实验研究表明,在皮肤损伤及愈合过程中,伴随着Caspase的活化和表达,这可能与Caspase诱导细胞凋亡的发生有关。深入研究Caspase在皮肤损伤及愈合过程中的作用机制,有望为皮肤损伤的治疗和法医学损伤时间的推断提供新的方法。本文综述了Caspase家族的生物学特性以及Caspase在皮肤损伤及愈合过程中的研究进展,认为Caspase在皮肤损伤及愈合过程中发挥重要作用,具有深入研究的必要。