Caspase与皮肤损伤

Caspase家族,目前已知至少由14个成员组成,该家族成员在细胞凋亡过程中发挥着重要作用。实验研究表明,在皮肤损伤及愈合过程中,伴随着Caspase的活化和表达,这可能与Caspase诱导细胞凋亡的发生有关。深入研究Caspase在皮肤损伤及愈合过程中的作用机制,有望为皮肤损伤的治疗和法医学损伤时间的推断提供新的方法。本文综述了Caspase家族的生物学特性以及Caspase在皮肤损伤及愈合过程中的研究进展,认为Caspase在皮肤损伤及愈合过程中发挥重要作用,具有深入研究的必要。     

损伤皮肤创缘白蛋白、总蛋白含量测定与损伤时间推断

本文利用生化自动分析仪,快速检测大白鼠背部皮肤剪创创缘组织中白蛋白、总蛋白含量。结果发现,生前各损伤时间组创缘中白蛋白、总蛋白含量明显升高;升高的程度与损伤时间有关。死后损伤各组白蛋白、总蛋白值与正常对照皮肤比较无显著差异。这表明生化自动分析仪检测损伤皮肤白蛋白、总蛋白含量的方法对于推断损伤时间具有一定的参考价值。     

Examining psychopathy from an attachment perspective: the role of fear of rejection and abandonment

A key feature of psychopathy, a self-centered orientation towards others and a failure to truly connect, is poorly understood. The attachment framework can be used to examine underlying interpersonal mechanisms. Because of the overall failure to connect, we anticipated, and found, in a large undergraduate sample (n?=?1074) that both affective-interpersonal traits and impulsive-irresponsible psychopathy facets were positively related to attachment avoidance. Different dynamics may underlie this distancing from others, as evidenced by the fact that callous-unemotionality was negatively related to attachment anxiety, whereas grandiose-manipulative and impulsive-irresponsible traits were positively related to attachment anxiety. Although effect sizes were small and are of correlational nature, our results are in line with a dual deficit model that differential developmental trajectories, largely heritable callousness vs. neglecting and abusive parenting, may lead to adult psychopathy. The differentiating role of fear of rejection and abandonment for the psychopathy construct is discussed.     

城市安全不能承受之重与流动人口不能承受之轻——兼论北京市流动人口犯罪预警机制的作用与完善

构建流动人口权益保障体制对于维护城市安全具有重要作用。本文分析了北京市流动人口犯罪的现状与原因,强调理性对待流动人口犯罪的必要性,提出应平等对待流动人口、在控制人口盲目流动的同时应当保障流动人口的基本权益,并发挥犯罪预警机制在预防流动人口犯罪中的作用。     

奇正伤湿止痛膏对大鼠皮肤角质层影响的实验研究

目的探讨奇正伤湿止痛膏用药期间和停止用药后对大鼠皮肤角质层超微结构的影响。方法选用10周龄Wistar大鼠，在其背部两侧皮肤涂抹含伤湿止痛膏药物的浸膏和不合药的对照膏剂，应用电子显微镜观察该药剂引起的皮肤角质层超微结构的变化。结果与对照膏剂比较，涂药4～12h后表皮角质层开始变薄，细胞间距增大，细胞结构变得比较疏松，外层细胞有脱落。1d后，角质层疏松减轻，细胞间距缩小。停药后第1天，表皮角质层细胞间距变小。停药3d后，表皮角质层已基本恢复正常。结论该膏剂主要通过降低皮肤角质层的屏障作用，促进药物透皮吸收效率。停止用药后表皮角质层变化可短时间内恢复正常。