富硒康对冠心病心绞痛增效的临床观察

８６例冠心病患者随机分为４８例和对照组３例，两组均给予心痛定，治疗组加用富硒康治疗。结果表明，治疗组改善心绞痛症状和心电图的总有效率分别９１．６７％和７２．９２％，较对照组的７６．３２％和５０％均有显著优势（Ｐ〈０．０１），同时，治疗组对血液流变学及ＴＣ、ＴＧ、ＨＤＬ－Ｃ各项均有显著的改善作用（Ｐ〈０．０５或〈０．０１），而对照组上述各项均改善不明显（Ｐ〉０．０５）。由此显示，富硒康对心痛定治疗冠     

中国城市化的挑战与城市可持续发展

2 1世纪是中国城市化发展战略实施的关键时期 ,中国的城市化成功与否直接影响中国经济的顺利发展。城市化的加速对城市的可持续发展是一个严峻的挑战 ,如何面对城市化的挑战 ,研究城市化与城市可持续发展是一个很有意义的课题     

基质金属蛋白酶与心血管疾病及其法医学意义

在心血管疾病发病机制中起重要作用的蛋白质大分子,对于心脏性猝死的发生及确诊具有十分重要的意义。基质金属蛋白酶(Matrixmetalloproteinases,MMPs)是一类锌依赖的金属内肽酶的总称,是降解心肌细胞外基质最重要的蛋白水解酶类。本文就基质金属蛋白酶生物学特性、功能在心血管疾病发生发展中的作用和在法医病理学中的意义作一介绍。     

中国户籍制度与城市化进程的反思

中国户籍制度像一道不可逾越的鸿沟,将中国分为泾渭分明的两大块:城市社会和农村社会。由此,强化二元经济结构,延缓了城市化进程。当前要加快城市化发展步伐,统筹城乡发展,建设和谐社会,必须改革现行户籍制度,但时下尚有人士对改革户籍制度疑虑重重,担忧引发“城市病”。这种观点不仅理论上缺乏科学依据,而且实践中将有碍户籍制度改革和“三农”问题的解决,进而影响城市化进程。     

Comprehensive analysis and investigation of accident/occupational disease responsibility rates: A case study for accidental CO poisoning

One of the major problems of courts and insurance companies is the lack of a proper technique to determine the rate of responsibility of the parties involved in the accident. The aim of this study was to determine the Accident/Occupational Diseases Responsibility Rates (AOD RR) for complex events. Accordingly, a case study of a complex accident of carbon monoxide (CO) poisoning was selected and Occupational Accident Tree Analysis (OATA) and Occupational Accident Component Analysis (OACA) techniques, which were solely used to investigate occupational accidents, were used with the new names Accident/Occupational Disease Tree Analysis (AOD TA) and Accident/Occupational Disease Component Analysis (AOD CA) to evaluate their applicability to investigate non-occupational accidents and occupational diseases. For this purpose, causes of CO penetration to victims’ room was assessed using gas tracking methods. Finally, Fuzzy Accident/Occupational Disease Tree/Component Analysis (FAOD TA and FAOD CA) techniques were developed and used for determining AOD RR in fuzzy environment. The results showed that the AOD RR obtained by AOD TA and AOD CA based on the average of experts’ personal opinions and consensus between experts, and AOD TA and AOD CA in a fuzzy environment were close to each other, with the power terminal and the power cable crossing route being the main routes of transmission and penetration of CO to the victims’ room. Also, the owner, contractor, tenant, and serviceman were responsible for the CO poisoning of victims. It can be concluded that any hole, crack, or fission in the building can result in CO penetration to the individuals’ living rooms, and gas tracking in early winter, especially in older buildings, plays a very significant role in preventing residents’ poisoning. Further, due to the uncertainty of AOD TA and AOD CA techniques, it is recommended to use FAOD TA and FAOD CA techniques for increasing the accuracy of the results. This will enhance the court and insurance companies’ trust in the opinions of accident investigation experts, decrease delays in the proceedings, and prevent any violation of the individual rights.     

Sudden Death Due to Undiagnosed Rheumatic Heart Disease in a Child

We report the case of a 5‐year‐old boy who died from complications of rheumatic heart disease with atypical presentation. He was hospitalized for recent inflammatory and neurological symptoms. He was diagnosed with viral encephalitis. He died the day after he was discharged. The macroscopic autopsy findings were unremarkable. Histology revealed typical rheumatic heart disease. Neuropathology showed cerebral infarction due to an embolic event linked with the rheumatic valvulitis. The cause of death was determined as heart failure due to rheumatic heart disease secondary to an undiagnosed acute rheumatic fever. It is related to an autoimmune response to infection with group A streptococcus. It mainly affects children in developing countries. In our case, viral encephalitis was consistent with the medical history and the proper diagnosis was made on histological analysis. Forensic pathologists should consider this diagnosis facing a sudden unexpected death in childhood, even in industrialized countries.     

Inferior Vena Cava Tumor Thrombosis Secondary to Metastatic Uterine Cancer: A Rare Cause of Sudden Unexpected Death

Pulmonary tumor thromboembolus (PTTE) secondary to uterine cancer is a rare cause of sudden unexpected deaths in the elderly population. Additionally, tumor extension to the inferior vena cava (IVC) makes it rarer. No such cases have been previously reported in the forensic literature. We report this phenomenon in a previously healthy 70‐year‐old woman with no other known risk factors for the development of deep vein thrombosis. The deceased was found dead while watching television with her relatives. Autopsy examination revealed that her death was attributed to a saddle embolus lodged in the main pulmonary arteries. A uterine tumor was discovered, and microscopic examination revealed low‐grade endometrial stromal sarcoma with angiolymphatic invasion. The tumor cells were also found in the embolus and the remnant thrombosis attached to the inner wall of the IVC. This case demonstrates a sudden unexpected death caused by acute PTTE following seeding of uterine cancer into the IVC and raises awareness of such events.     

17例颈椎外伤合并颈椎退行性病变的伤病关系分析

目的研究颈椎外伤合并颈椎退行性病变的法医学鉴定案件特点,探讨如何利用临床资料,法医学检查和影像学检查等对损伤和病变参与程度进行认定等问题。方法收集17例颈椎外伤合并颈椎退行性病变的法医学鉴定案例,对其年龄分布、损伤方式、损伤程度、影像学表现等进行分析,综合评定伤病关系。结果 17例案件以中老年为主。所有案例均存在椎间盘突出,损伤以过伸性损伤为主。按照影像学表现,将损伤程度和脊椎退变程度进行分级,综合计算伤病参与程度。结论颈椎外伤合并颈椎退行性病变的法医学鉴定案件应综合运用临床资料、法医学体格检查和影像学检查结果进行评定。     

口蹄疫病毒单链抗体基因的构建及其推导蛋白三维结构的分子模拟

用口蹄疫病毒(FMDV)Asial/JS/China/2005株灭活抗原免疫家兔,从兔脾细胞中提取RNA作为模板,通过PCR及重叠PCR方法构建出FMDV的单链抗体基因.测序结果显示,序列中有重链可变区(VH)及轻链可变区(VL)基因,经Blast比较,发现VH、VL的相似性最高分别可达81.0%和93.0%,且在序列中有连接VH及VL的柔性接头(Gly_4Ser)_3.用EXPASY软件包预测了推导蛋白的特性.运用Swiss-pdb viewer软件的SWISS-Model处理器对构建的单链抗体基因推导的蛋白序列进行了三维结构的分子模拟.拉马钱德兰图证明,所模拟的单链抗体的三维结构较为合理.     

日据时期台湾医师的疾病医疗书写研究

日据时期台湾出现了新兴的医师阶层,很多医师参与文化活动,并有关于病理症状与医疗想象的书写.这些隐喻书写透露出在殖民现代化过程中,台湾医师对疾病医疗的态度,以及对医疗现代化、传统中医乃至公共卫生等问题的看法.