Identification of Eight Synthetic Cannabinoids,Including 5F‐AKB48 in Seized Herbal Products Using DART‐TOF‐MS and LC‐QTOF‐MS as Nontargeted Screening Methods

Synthetic cannabinoids are sprayed onto plant material and smoked for their marijuana‐like effects. Clandestine manufacturers modify synthetic cannabinoid structures by creating closely related analogs. Forensic laboratories are tasked with detection of these analog compounds, but targeted analytical methods are often thwarted by the structural modifications. Here, direct analysis in real time coupled to accurate mass time‐of‐flight mass spectrometry (DART‐TOF‐MS) in combination with liquid chromatography quadruple time‐of‐flight mass spectrometry (LC‐QTOF‐MS) are presented as a screening and nontargeted confirmation method, respectively. Methanol extracts of herbal material were run using both methods. Spectral data from four different herbal products were evaluated by comparing fragmentation pattern, accurate mass and retention time to available reference standards. JWH‐018, JWH‐019, AM2201, JWH‐122, 5F‐AKB48, AKB48‐N‐(4‐pentenyl) analog, UR144, and XLR11 were identified in the products. Results demonstrate that DART‐TOF‐MS affords a useful approach for rapid screening of herbal products for the presence and identification of synthetic cannabinoids.     

Obesity,Body Mass Index,and Homicide

The body mass indexes (BMIs) of 100 randomly selected homicide cases from the files of Forensic Science SA were compared to the Australian and South Australian populations. There were 70 males and 30 females (M:F = 2.3:1; age range 18–84 years; mean 42.3 years). There was a substantially lower proportion of obese individuals in the homicide population compared to the general Australian and South Australian populations (19% [vs.] 27.9% and 30%, respectively). A second group of 144 randomly selected autopsy cases where the BMI was ≥40 kg/m² was analyzed. There were 77 males and 67 females (M:F = 1.2:1; age range 23–78 years; mean 46.7 years). The majority of deaths were natural (N = 108), with no homicides. A negative association between obesity and homicide has, therefore, been demonstrated. Reasons for the lower numbers of obese/morbidly obese individuals among homicide victims are unclear, but may include physical protection afforded by fat padding from sharp force injuries, and relative sociodemographic isolation.     

Drug Recognition Evaluation and Chemical Confirmation of a 25C‐NBOMe‐Impaired Driver

This case report details an individual arrested for drug‐impaired driving after leaving the scene of multiple motor vehicle collisions and evading police. The driver was examined by a drug recognition expert and failed the drug recognition evaluation. The driver admitted to using cocaine, marijuana, an antidepressant medication and “N‐bomb,” a novel psychoactive substance that possesses hallucinogenic properties. Toxicological analyses at the Centre of Forensic Sciences’ Toronto laboratory revealed only the substance 2‐[4‐chloro‐2,5‐dimethoxyphenyl]‐N‐[(2‐methoxyphenyl)methyl]ethanamine (25C‐NBOMe) in the accused's urine. This is the first report in which 25C‐NBOMe was identified through DRE and toxicological analyses in a drug‐impaired driver.     

论我国未成年人监护制度的完善

未成年人监护制度是监护制度的重要组成部分,它不仅关系到保护未成年人的合法权益,而且还关系到社会秩序的稳定。目前,我国监护制度中还存在着监护机构设置不合理、监护人的选任缺乏一定的标准、监护人的职责及权利不明、监护的种类不全等问题。为了更好地保护未成年人的利益,针对上述不足,提出自己的建议。     

中小企业融资难问题的法律破解

中小企业融资难问题已深深制约着我国中小企业的发展壮大,在直接融资和间接融资两种方式中存在融资难有法律方面的原因,为解决中小企业融资难的问题,提高中小企业融资能力,文章分别就中小企业在直接融资和间接融资两种融资方式上融资难问题提出了破解办法。     

关于外资企业民主管理多元化的思考

与国有企业相比较,外资企业实行民主管理具有自身的特殊性。由此决定了外资企业在实行民主管理过程中,必须根据企业实际,在内容和形式上进行探索,采取多种途径和灵活的方法,以达到民主管理的实际效果。     

试析高校工会干部的人格力量

高等教育的改革与发展、高校工会工作对象的特殊性、高校工会工作的性质等决定了高校工会干部必须塑造高尚的人格,以自身的人格力量来做好工会工作。高校工会干部的高尚人格对其自身发展具有调节作用,对教职工、校风及社会风气具有影响作用。因此,要加强高校工会干部人格力量的培养。     

创造国际直接投资新环境开拓中俄经贸合作新局面

中俄两国经贸关系走上了正常发展的轨道,相互投资成为深化两国经济关系的重要内容。国际直接投资是突破贸易壁垒、进入一国市场的重要手段,也是稳定中俄经济关系的根本基础。中俄相互投资存在经济转轨尚未完全实现、法律法规不健全、缺乏有效的筹资渠道、沟通渠道不畅等制度性和基础性障碍。为促进中俄两国相互投资健康、快速发展,应在签定双边投资协定、建立中俄商业协会、开辟投资融资途径、相互建立工业园区以及举办投资洽谈会等方面构建相互投资的宏观环境。     

对重复保险若干法律问题的思考

我国《保险法》对重复保险的界定并不全面 ,对其概念应采狭义说 ;重复保险的构成要件 ,尚欠缺保险金额总和超过保险价值及保险期间发生交叉或重合两个要件 ;重复保险的适用范围 ,应限于具有损失填补性质的险种 ;对重复保险的法律效力 ,应区分善意和恶意 ,并采取不同的规制原则。     

Validation of thin layer chromatography with AccuTOF-DART™ detection for forensic drug analysis

Abstract: Thin layer chromatography (TLC) is a technique that is commonly employed in the forensic drug analysis of pharmaceutical preparations. Detection is typically accomplished using various visualization spray reagents. Conventional gas chromatography–mass spectrometry (GC‐MS) analysis is typically performed to confirm the TLC results. Depending on the drugs tested and the instrument conditions required, this confirmation can take up to an hour to complete. Direct analysis in real time (DART?) is an ionization source, coupled to an accurate‐mass time‐of‐flight mass spectrometer that has the capability to ionize materials under ambient conditions. To streamline analysis, the combination of TLC with DART? detection is proposed to screen and subsequently identify drug compounds, all from the same TLC plate. DART? confirmations of TLC analyses take <10 min to complete and compare favorably to GC‐MS in sensitivity and selectivity. This study validates the use of TLC‐DART in the forensic identification of the components of several pharmaceutical preparations.