Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case

For several years, the misuse of stimulant substances is increasingly observed both in the field of sport, to improve the functions of the body and therefore to be more performant, and also by non-athletes to make life more tolerable on a daily basis. Adrafinil, 2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. It is primarily metabolized in vivo to an active form, i.e. modafinil, 2-((diphenylmethyl)sulfinyl)acetamide. The World Anti-Doping Agency (WADA) banned these two drugs in sports in 2004. The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in possession of vials of adrafinil and suspected of trafficking. A specific method was developed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Unlike modafinil (varying from 6.8 to 13.9 ng/mg), adrafinil was not identified in the strand. The interpretation of the results was difficult because this is the first case describing human hair analysis. In order to be able to interpret the results, a self-administration study was conducted after an oral administration to a volunteer (200 mg) whose beard hair was collected 10 days after administration. The analysis of this specimen highlighted the presence of adrafinil at 0.8 ng/mg and modafinil at 0.5 ng/mg. These results demonstrate the dual identification of both compounds after a single consumption, even after administration of a low dose. According to these results, the analysis of the hair strand from the authentic case does not match with a consumption of adrafinil, in accordance with abuse of modafinil alone. Intelligence considered that this was a trafficking case of adrafinil, with no self-consumption.     

在饲料添加剂中加入人药不构成生产、销售伪劣产品罪--以李某某案为例

李某某在饲料添加剂中加入人用降糖药格列本脲,其行为违反了相关行政法规和行业标准。但是,从法条文义上看,李某某的行为不属于在产品中掺杂、掺假,以假充真,以次充好,以不合格产品冒充合格产品;从法益保护上看,李某某的行为没有损害产品市场诚实交易的秩序和用户、消费者的合法权益;从罪名之间的协调性上看,李某某的行为不符合构成生产、销售伪劣产品罪的实质要件;从违法性判断的相对性上看,李某某的行为不应属于刑法规制的对象。因此,李某某在饲料添加剂中加入格列本脲的行为不构成生产、销售伪劣产品罪。     

Security-Civil Liberties Trade-offs: International Cooperation in Extraordinary Rendition

Following the launch of the WoT, the United States established a global rendition network that saw the transfer of Central Intelligence Agency (CIA) terrorist suspects to secret detention sites across the world. Conventional accounts of foreign complicity show that 54 diverse countries were involved, including many established democracies. What determined more than a quarter of the world’s countries to participate in RDI operations during the post-9/11 period? Given the sensitive nature of cooperation required, I argue that the United States screened countries according to their preferences on security-civil liberties trade-offs. Countries with similar preferences to the United States on human rights were cheaper to buy off and would have required less persuasion to cooperate. This theory is consistent with the existing claim that cooperation is more likely between countries with similar preferences as both actors are better off when the partnership increases. I test this hypothesis on global data using UNGA voting data as a proxy for common interest and develop a spatial variable that models a country’s logistical utility during the transfer of a detainee based on its distance to a central rendition transit corridor between the United States and Afghanistan. The analysis provides robust empirical support for my theoretical argument.     

Coordinating Transitional Justice

Conflict resolution professionals sometimes differ from human rights professionals about the best approaches to transitional justice, particularly with regard to the scope, conditions, and timing of possible amnesties from prosecution for perpetrators of war crimes and human rights abuses. When human rights and conflict resolution professionals work at cross‐purposes, they may work less effectively to end conflict, abuses, and crimes, and to implement peace accords. A consensus among conflict resolution and human rights scholars about which legal norms should govern post‐conflict amnesty programs appears to be developing. Against this emerging legal framework, human rights and conflict resolution professionals should, I argue, develop processes for working together more effectively in the design and implementation of context‐sensitive approaches to transitional justice. These process principles should address the entire conflict period, from escalation through resolution to post‐conflict reconstruction. In this article, I describe a tentative, general framework for coordinating the development of transitional justice programs. This proposed framework is intended to stimulate and guide discussion of these issues among conflict resolution and human rights professionals and scholars.     

Funding,capabilities and the use of child soldiers

Recent years have seen increased scholarly attention given to the issue of child soldiering. Primarily dedicated to the decision-making calculus of rebel groups, this body of work has generally emphasised supply-side versus demand-side arguments. We contribute to this growing literature by explicitly investigating a previously untested aspect of the latter. Prior scholarship has made vague references to a potential association between economic endowments and child soldiering, including natural resource wealth, but scant empirical attention has been given. We argue that the specific type of endowment has important consequences for the decision to utilise child soldiers. We argue access to and exploitation of lootable natural resources (e.g. gemstones) to be especially likely to promote the use of child soldiers due to their ease of access, the low skills required to harness them and the heightened likelihood that groups will become more profit-oriented. A systematic cross-national investigation of rebel groups provides robust evidence that lootable resources such as diamonds and gemstones are strongly associated with the use of children, while non-lootable resources such as oil are not.     

Enforcing labour rights of irregular migrants in Indonesia

The multi-directional nature of labour migration flows has resulted in an increasing number of countries having become both senders and receivers of regular and irregular migrants. However, some countries continue to see themselves primarily as senders and so ignore their role as a receiving country, which can have negative implications for the rights of migrants in their territory. Using the example of Indonesia, which is State Party to the 1990 UN Convention on the Rights of All Migrant Workers and Their Families, this article demonstrates that irregular migrant workers in this country have the legal right to protection against labour exploitation even when they work despite the government’s prohibition on employment. The article discusses the ‘right to work’ and how international human rights law has translated it into the ‘right to protection from labour exploitation’ for irregular migrants in Indonesia. By way of two case studies about the Indonesian government’s handling of irregular migrants, it shows how it prioritises enforcement of the employment immigration law over labour and employment laws much like countries that have not ratified the ICRMW. It also draws attention to legal protection gaps that emerge for asylum seekers when they are recognised to be genuine refugees.     

Linking Organizational Climate to Work Engagement: A Study in the Healthcare Sector

Using a two-level structural equation approach, this article investigates the links between organizational climate and work engagement in a sample of public hospitals in Italy. Drawing from the Job Demands-Resources model, the model posits a positive association between work engagement and a climate promoting worker’s autonomy, empowerment, and well-being, whereas it suggests that a climate based on efficiency and goal attainment is not favorable for engagement. Results support the hypotheses and suggest that performance based models implemented in recent years as part of public sector reforms are not conducive to engaged workers. Implications for research on work engagement in the public sector and for public management are drawn.     

How democratic decentralisation facilitates,sustains, and interrupts market-driven development in India

Democratic decentralisation has emerged as an instrument to implement market-driven development, and elected bodies now extend commercial inputs for commodity production and link households to firms. However, the nature of market-driven development under this condition is understudied. This article focuses on an Indian case where, while access to market inputs was shaped by political capital with elected leaders, narrowing market participation, leaders – now market intermediaries – fostered trust in firms, helping sustain market participation. Conflicts over electoral politics interrupted market production. Markets rely on state institutions and are intertwined with politics, contrary to market proponents’ claims that markets stand above society and are unmediated spaces of exchange.     

Climate change research in bilateral development programmes: experiences from India and Peru

This article reflects on the merits and shortfalls of bilateral research programmes aimed at strengthening climate change research capabilities, using the experience from two programmes, the PACC and IHCAP in Peru and India, respectively. The study highlights key aspects of these types of bilateral programmes, namely: capacity; performance, salary and appreciation; funding; bureaucracy and hierarchy; publishing; and data sharing. Furthermore, it emerged that these programmes would benefit from a more extensive consolidation phase of the research activities and partnership rather than rapidly transferring into out- and up-scaling phases.     

Participatory modelling and development practice: artisanal fishers in Nicaragua

Development plans with insufficient knowledge about local realities, and that do not share technical or planning details with the target communities, bedevil development practice. This study used a form of participatory modelling in three fishing communities in Nicaragua to enable fishers to explore their economy and the potential impacts of fishery-based development projects. Co-designing a model of the fishing economy in the form of a board game created a forum in which facilitators and participants could arrive at a shared understanding of local fishing practices and the costs and benefits of strategies for addressing the fishers’ priorities.