Genetic Variants in KCNE1, KCNQ1, and NOS1AP in Sudden Unexplained Death During Daily Activities in Chinese Han Population

Fifty‐six sudden unexplained death (SUD) cases were collected from Chinese Han population, which occurred during daily activities and were autopsy negative in comprehensive postmortem autopsy. The coding exons of potassium channel genes KCNE1, KCNQ1, and nitric oxide synthase gene NOS1AP were sequenced. A synonymous mutation, KCNE1 F54F T>C was identified in 2 SUD cases, which was absent in the control subjects. Neither genotype nor allele frequencies of KCNE1 and KCNQ1 exhibited a significant difference between the SUD and control group. In contrast, the allele frequency (p = 2.7 × 10⁻¹⁰) and genotype frequency (p = 5.9 × 10⁻⁷) of rs3751284, and the genotype frequency (p = 2.9 × 10⁻²) of rs348624 in NOS1AP of SUD were significantly different from that of controls (p < 0.05). Our study suggested that rs3751284 and rs348624 might be susceptibility loci for SUD during daily activities. Larger sample sizes and further molecular studies are needed to confirm or exclude an effect of the NOS1AP SNPs on SUD risk.     

物流业物货流通中的治安监管

我国的物流企业逐渐成熟,给人们生活带来方便,但由于物流寄递渠道人货分离的特点,不法分子利用物流企业监督管理不到位,规章制度不落实的漏洞,通过物流渠道夹带贩运枪支弹药、爆炸物品、危险化学品、管制刀具、毒品等禁寄物品以及盗窃、冒领、隐匿、毁弃、私拆货物邮件的案件和问题逐年增多。针对当前物流行业存在的问题,公安机关有必要对物流行业在各环节中出现的问题进行治安监管。     

论《道德经》无为而治的国家社会管理思想

无为而治是《道德经》国家社会管理思想的重要内容,是老子认为最好的管理方法。无为而治不是消极的主张,而是要经过努力才能达到的理想的管理状态。要实现无为而治,必须深刻理解它的含义,管理者必须有自知之明,还必须起好表率作用。无为而治思想,包含丰富的合理内核,有重要的现实意义。     

经济合同语言表述问题探讨

经济合同是经济活动中所签订的具有法律效力的契约文书，经济合同语言是体现经济合同职责的语言、文字符号等工具的总和，它存在于经济活动的全过程中。经济合同的订立不可草率，必须慎重，要做到模式规范，内容明确，字词得当，准确运用语言文字订立经济合同，对保护合同有关当事人的合法权益，具有十分重要的意义和作用。     

欧盟公司确定资本制度改革之必要与路径——维持原状、废旧立新还是新旧整合

欧盟作为跨法系实体，欲统一其公司法律制度，关于公司确定资本制度改革刻不容缓。公司确定资本制度既会极度阻碍效益增长，又难切实保障市场安全。纵观债权人利益事前保护、事中保护、事后保护三大环节，公司确定资本制度划定最低资本额所带来的事前保护作用非但不可或缺而且不能取代，将之与到期债务能力测试或资产负债比例原则的事中保护和破产制度的事后保护相结合，债权人法律保护的体系化效用就将彰显无疑。     

零售终端商业模式的演进及其适应

近年来,日益激烈的竞争导致渠道的扁平化与渠道控制中心向渠道终端或消费者购买一极转移,同时零售终端的商业模式也发生着巨大的变革。对面如此变化,制造商与分销商应调整其分销渠道。零售终端商业模式是分销渠道调整首先考虑的问题。要从研究消费者渠道偏好与购买准则入手,认识与把握零售终端商业模式的演进规律,找到零售终端策略的改进思路。     

论自救行为及其立法实现

自救行为是私力救济的重要表现形式,自救行为的本能性、现实性与补充性是其正当化根据。自救行为具有独立性,与正当防卫存在时间要件、行为性质、行为限度等多方面差异。自救行为必须保持必要限度,可以＂强度的基本适应＂作为是否过当的主要标准,同时辅之以＂是否必需＂等其他因素进行综合判断。对自救行为应当进行刑事立法,统一认定标准,通过对自救行为等私力救济形式的适当引导与约束,实现对公民权利的全面保障。     

FROM THE INSIDE OUT: CALLING ON STATES TO PROVIDE MEDICALLY NECESSARY CARE TO TRANSGENDER YOUTH IN FOSTER CARE

It is well known that transgender youth in foster care often face egregious discrimination and victimization based on their gender identities. Unfortunately, transgender youth in foster care have also been deprived of transgender-specific medical care that is vital to their health and well-being. This Note advocates that child welfare agencies adopt legislation that will demonstrate their commitment to fulfilling their constitutional duty to provide medically necessary care to transgender youth in their custody. This Note examines recent case law on the topic and addresses counterarguments to the proposal, including risks associated with treatment, high cost, and the stigma of gender identity disorder. Ultimately, this Note concludes that adopting the proposed legislation is a necessary step toward securing health care rights for transgender foster care youth.     

提升铁路线路治安工作质量的思考

铁路线路治安稳定对社会经济发展起着重要作用。在全路公安领导干部“10·17”会议上,部局党组专门提出要将创建线路治安绿色通道活动作为“两大任务”和“五大品牌”之一,全力打造推进。通过对蚌埠铁路公安处淮南车站派出所管内“二通道”淮南、阜淮等线路在日常治安防控中存在的问题及原因反思剖析,围绕如何进一步提升线路治安防控,从改进巡防机制、加强日常督导、提升宣传实效、狠抓隐患整治、推动综合治理等五个方面进行了阐述。     

论网络反腐信息传输渠道的构建

网络反腐信息传输渠道已经成为影响网络反腐效能有效发挥的重要因素之一。目前,我国网络反腐信息传输渠道仍存在传输渠道技术缺乏整合、民间网络反腐信息传输渠道有待规范、政府与民间两类网络反腐信息传输渠道互动性有待增强等问题。因此,要构建以网络反腐信息输入、处理、输出及反馈为主要环节,以反腐信息HBU系统为核心,兼具开放可循环特征的反腐信息传输渠道,采取信息分级、加强政府—民间网络反腐信息传输渠道的对接与信息反馈等具体措施,为进一步完善网络反腐渠道,提升网络反腐水平提供理论支持与实践参考。