新藤黄酸对人乳腺癌耐药细胞体外作用的研究

目的 观察新藤黄酸(gambogenic acid,GNA)对人乳腺癌耐药细胞MCF-7/ADR的作用。〖JP〗方法 采用MTT法观察GNA、阿霉素(adriamycin,ADR)及两者联用对MCF-7/ADR细胞增殖的抑制作用,采用流式细胞仪观察MCF-7/ADR细胞内ADR浓度。结果 GNA能剂量依赖地抑制MCF-7/ADR细胞的生长,作用48 h时,GNA对MCF-7/ADR细胞的IC50为12.88 μmol/L;4 μmol/L GNA可增加MCF-7/ADR细胞对ADR的敏感性,使ADR对MCF-7/ADR细胞的IC50 由80.22 μmol/L降至12.54 μmol/L;GNA显著增强MCF-7/ADR细胞内ADR的积累,呈剂量依赖关系。结论 低剂量GNA能显著增加MCF-7/ADR细胞对ADR的敏感性。     

To Care and Protect: Care Workers Confronting Sweden Democrats in their Workplace

Austerity policies across European countries have encountered diverse forms of public protest and resistance. In Sweden, we have seen the emergence of a number of networks and organizations which take care workers’ professional identity as their point of departure. These networks and organizations stress the impossibility of being professional care workers in slimmed-down, neoliberal organizations. Parallel to this, and sometimes embedded into one another, female-dominated professions (e.g. social workers, nurses, doctors, and teachers) have been engaged in opposing restrictive refugee policies. This article analyses how care workers in an emergency room in Malmö mobilized against a visit by Jimmie Åkesson, leader of the right-wing, xenophobic Sweden Democrats. The article explores how workers used a gendered discourse of care and professionalism to argue that their actions were consistent with both organizational culture and their professional ethics. The article shows how, by defending their professional role of providing quality care to all in need, workers challenge both austerity and racist policies, which both impose restrictions on who has the right to care. Theoretically, the article explores how the politicization of care creates spaces of resistance, to critique both austerity policies and exclusionary understandings of national belonging. The study stresses the importance of identifying emerging forms of collective resistance among care workers at the intersection of the struggles against austerity and right-wing xenophobic parties.     

Abnormal fears: the queer Arctic in Michelle Paver’s Dark Matter

With focus on queer resistance emanating from place, this article examines Michelle Paver’s 2010 novel Dark Matter: A Ghost Story, set in the 1930s and focused on an all-male expedition to Svalbard. As representatives of the norm, the fictional expedition members attempt to enforce heteronormative models of interpretation characterizing depictions of the Arctic, but several aspects blur the boundaries between previously discreet categories. Starting from Sara Ahmed’s discussions about spatial and existential orientation in Queer Phenomenology (2006), the article maps how the Arctic is imagined and perceived by Jack Miller, the novel’s protagonist. Although hoping that Svalbard will constitute a productive testing ground for a particular kind of inter-war, British masculinity, specificities of place represent a progressively more threatening transgression of what Jack perceives of as normal. The Arctic is thus initially constructed as a stable place; geographical particularities then overturn possibilities for Jack’s orientation, and supernatural occurrences finally violate boundaries between past and present, sane and mad. What Ahmed refers to as ‘queer moments’ that slant that subject’s perception of the world are in the novel produced by the actual as well as the supernatural Arctic: they highlight a continuous, geographically specific resistance to categorization.     

Postmodern Global Governance and the Critical Legal Project<Superscript>1</Superscript>

The crisis of the New Deal constitutions and the shift to ?biopolitical’ forms of global governance in the late 20th century have dramatically disturbed the epistemological groundings and the political locations of contemporary critical legal movements. In epistemological terms, the emergence of the ?biopolitical’ has rendered transparent the impossibility of the binaries that have thus far sustained critical legal theories. With the divide between ?inside’ and ?outside’, ?base’ and ?superstructure’, ?state’ and ?society’, ?society’ and ?law’, no longer operative, critical legal movements have to outgrow their legal realist ?roots’. Could deconstruction provide here a viable option? Confronted by an order of governance that is now both ?global’ and ?imperial’, critical legal movements cannot recover a politics through such ephemeral theories. Rather, the future of critical legal movements must be located in an affirmation and promulgation of radically new constitutional principles which would confront the realities, but also harness the emancipatory potential, of the ?biopolitical’ horizon [eds.].     

Anti-Royalism in Thailand Since 2006: Ideological Shifts and Resistance

Since the military coup d’état of 2006 and the downfall of Prime Minister Thaksin Shinawatra, Thailand has experienced chronic political turmoil. Crises of legitimacy expanded to engulf every political institution. This includes the monarchy, usually claimed to be the most “beloved” and “revered” of all institutions, and which has faced widespread anti-royalism since 2006. In this article, it is argued that this recent anti-royalism was neither a well-planned scheme or plot, as claimed by the country’s military junta, nor driven by Marxist or republican ideologies that featured in previous bouts of anti-monarchism. Rather, the new anti-royalism will be shown to have emerged from the royalist hegemony that has been deepened since the late 1970s. Moreover, anti-royalist ideas and expressions have shifted dynamically as society has become more polarised. Thailand’s political conflict is overwhelmingly characterised by contestations over meanings. In this context and in a highly repressive political and legal context, those who wished to challenge royal power used metaphorical ambiguity, jokes, vulgarity and parody on a daily basis. These arts of resistance were reproduced through popular channels which tended to escape state surveillance, for instance, protest songs, poetry, chats at gathering sites, formal and informal speeches, and symbols in both on and offline worlds.     

Chechen ethnic identity: assessing the shift from resistance to submission

This article critically assesses the ostensible transformation in Chechen ethnic identity. Journalists and scholars who came to this conclusion based their claim on obvious changes in Chechen behavior. The brave and irreconcilable resistance the nation demonstrated during the First and the Second Russo-Chechen Wars of 1994–1996 and 1999–2009, respectively, was replaced by a submissive and loyal stance with regard to the new authorities and recent enemies. This article investigates whether such a change in behavior reflects a corresponding change in ethnic identity. This article asserts that ‘non-Chechen’ behavioral models do not signify changes in Chechen ethnic identity by presenting and analyzing Chechen narratives concerning the question. In summary, this article concludes that the ethnic identity of the nation remained mainly untouched. This conclusion is supported by the observed continuity of Chechen resistance, which has always been driven by cherished values such as freedom.     

The sounds of silence: American history textbook representations of non-violence and the Abolition Movement

In this paper we examine how the Abolition Movement’s approach to non-violent resistance has been silenced in four American history textbooks. Despite extensive research that reveals an extensive network of groups dedicated to the peaceful abolishment of slavery little of this historical record is included in the textbooks. Instead, a skewed representation of the movement is conveyed to the reader, one that conveys an image of a movement that contributes to a climate of social violence. Through a critical discourse analytical approach to the data we carefully deconstruct how this process of misrepresentation occurs. By employing the discursive tools of narrative framing, positioning, and stance we lift up what is often hidden from the reader and demonstrate how language use communicates powerful social messaging to the reader. We argue that student readers are left with an impoverished sense of how non-violent democratic change has occurred when presented with a limited portrayal of the Abolition Movement. We therefore emphasize the importance of equipping students with the skills needed to critically interrogate both historical and contemporary sources that purports to convey the inevitability of war to resolve complex social problems; we maintain this is both an educational imperative and a civic obligation.     

Resilient Peace: Exploring the Theory and Practice of Resilience in Peacebuilding Interventions

ABSTRACT

This introduction provides a conceptual and theoretical background to the more detailed analyses contained in the articles of the Special Section. The introduction firstly presents a critical overview of the rise of resilience and its increasing role in shaping the terms of international interventions. It identifies a set of interrelated conceptual themes relevant to theorising the relationship between resilience and peacebuilding and evaluates how appropriate a resilience approach might be in promoting sustainable peace and what might be its main dangers and pitfalls.     

Ensuring the safe and effective FDA regulation of fecal microbiota transplantation

Scientists, policymakers, and medical professionals alike have become increasingly worried about the rise of antibiotic resistance, and the growing number of infections due to bacteria like Clostridium difficile, which cause a significant number of deaths and are imposing increasing costs on our health care system. However, in the last few years, fecal microbiota transplantation (FMT), the transplantation of stool from a healthy donor into the bowel of a patient, has emerged as a startlingly effective means to treat recurrent C. difficile infections. At present, the FDA is proposing to regulate FMT as a biologic drug. However, this proposed classification is both underregulatory and overregulatory. The FDA''s primary goal is to ensure that patients have access to safe, effective treatments—and as such they should regulate some aspects of FMT more stringently than they propose to, and others less so. This essay will examine the nature of the regulatory challenges the FDA will face in deciding to regulate FMT as a biologic drug, and will then evaluate available policy alternatives for the FDA to pursue, ultimately concluding that the FDA ought to consider adopting a hybrid regulatory model as it has done in the case of cord blood.     

Between Resistance and Compliance: Non-participation and the Liberal Peace

Abstract

This work is interested in the concept of non-participation in relation to international peace–support interventions. While the concept of participation has received significant attention, non-participation is under-conceptualized. A typology of non-participation is advanced, differentiating between voluntary and involuntary types of non-participation. It is argued that there is an overhasty tendency by many observers to subjectify inhabitants in post-war settings into the categories of resistance and compliance. This article rejects such a binary as too crude, and argues that non-participation needs to be examined in its own right, not automatically in relation to wider projects of liberal peacemaking or of resistance to that form of peacemaking.