电针“神门”穴对创伤后应激障碍小鼠行为学参数和前额叶皮质FKBP5表达的影响

目的 观察电针“神门”穴对创伤应激后障碍（post-traumatic stress disorder,PTSD）小鼠焦虑样行为及前额叶皮质FK506结合蛋白5（FK506-binding protein 5,FKBP5）表达的影响。方法 将C57小鼠随机分为正常组、模型组、电针组,每组6只。模型组和电针组小鼠采用单一延长应激加电刺激法复制PTSD小鼠模型。电针组小鼠每日针刺“神门”穴15 min,每日1次,连续14 d。利用旷场实验、高架十字迷宫实验检测小鼠行为学参数。采用实时荧光定量PCR法检测小鼠前额叶皮质FKBP5 mRNA表达水平,采用Western blot法检测小鼠前额叶皮质FKBP5表达水平。结果 旷场实验中,电针可明显提高模型小鼠中央区域停留时间、跨格次数（P＜0.05）;高架十字迷宫实验中,电针可明显增加模型小鼠开臂时间、开臂次数、开臂时间比、开臂次数比（P＜0.05）。模型组小鼠前额叶皮质FKBP5及其mRNA表达水平较正常组明显升高（P＜0.05）;电针组小鼠前额叶皮质FKBP5及其mRNA表达水平较模型组显著降低（P＜0.05）。结论 电针能明显改善PTSD小鼠焦虑样行为,其作用机制可能与增加PTSD小鼠前额叶皮质FKBP5的表达水平有关。     

Financial Stress and Depression Among African Refugees in the Southern United States: A Serial Multiple Mediation Analysis of Financial Self-Efficacy and Financial Anxiety

Abstract

As part of a larger community-based participatory research project exploring the postresettlement challenges of African refugees in the southern United States, our study investigated the phenomenon of financial stress and its relationship to mental health through a mediating chain of factors—financial self-efficacy and financial anxiety. Results revealed the mediating role of financial self-efficacy and financial anxiety on the relationship between financial stress and depressive symptoms. Findings provide discourses around financial stress and mental health in the migration context, critical to recognizing the unique experiences of African refugees and informing culturally responsive programs for financial inclusion and economic integration.     

Crime patterns and their relation to subjective social stress and support indicators: The role of gender

This study investigated the relationship between the subjective perception of stress and support in the population (as independent variables) and the prevalence of homicide, robbery, and property offenses in society, while controlling for the effect of gender, i.e., how these crimes are related to the differential perception of stress and support among males and females. The theoretical framework is provided by a stress-support model which postulates that crime in society will be positively related to stress factors and negatively related to support systems. Eight stress indicators and four support (solidarity) indicators were included. The data regarding these indicators were derived from continuing surveys of representative samples of the urban population in Israel during the years 1967–1979. The theoretical model was supported by the findings, especially those relating to property offenses. The effects of the female indicators were strongest (and greater than those of males) with regard to property offenses. The regression coefficients of the female indicators were also consistently larger than those of males, indicating that women's perceptions of stress are better predictors of crime rates than those of males. The results are compared to those of previous studies and suggestions are made for future studies in this new line of criminological research.     

Exploring the Stressors of Low-Income Women with Abusive Partners: Understanding Their Needs and Developing Effective Community Responses

This study examined how women's experiences of domestic violence may affect their level of stress, as measured by difficult life circumstances and stressful life events for 107 women living in poverty. Results indicated that women with abusive partners reported higher levels of stress than women who had not experienced abuse. Women's perceptions of how their experiences of domestic violence impacted their health and the type of events women perceived to be most stressful were also examined. Symptoms most frequently perceived to be a result of abusive experiences were heart pounding/racing, trembling hands, headaches, and sleep problems. Implications of the findings for research and community intervention are discussed, including the importance of providing not only crisis intervention services, but also the need to create and maintain long-term support and advocacy services for women who have experienced domestic violence.     

Prevalence and Correlates of Intimate Partner Violence Among a Sample of Construction Industry Workers

This study assessed the prevalence and correlates of intimate partner violence (IPV) among a sample of unionized construction industry workers, and tested the reliability of new measures of IPV normative beliefs. Study participants (n=100) voluntarily completed confidential and anonymous self-administered questionnaires that measured occupational factors, hazardous drinking, and normative beliefs. Measurement of past-year IPV was based on the Conflict Tactics Scale, Form R. Measures of IPV normative beliefs showed good reliability (Cronbach’s α 0.94–0.95). Past-year IPV prevalence was 26%. Logistic regression models were developed to assess the contribution of each factor to risk of past-year IPV perpetration. Perceived workplace racial/ethnic discrimination, job strain, interpersonal workplace conflict, normative beliefs, and hazardous drinking were positively associated with elevated IPV risk.Construction industry workers may have higher rates of IPV compared to general population samples that represent various occupations and social classes. Occupational factors appear to be significant correlates of IPV among these workers.     

心理学在监狱警察心理帮助中的具体应用

监狱人民警察高压力的工作性质，使长期处于心理应激状态的警察个体比其他职业更容易产生心理问题。而目前，我国监狱警察获得的支持和关怀远远低于其自身需要，国内有关监狱警察职业压力和心理帮助的研究也并不多，而要建立科学有效的监狱警察心理帮助系统，就必须运用心理学的研究成果及相关理论。     

An Examination of Officer Stress: Should Police Departments Implement Mandatory Counseling?

This study suggests that police departments who promote counseling benefit from officer stress reduction. Officers from sixteen municipal police departments (n = 1,114) across the state of Alabama possessed moderate stress, but were influenced significantly by organizational demographics (including counseling opportunities). A majority of officers believed that stress signs were not predictive of police suitability but remained reluctant to share fears and anxieties with fellow colleagues, suggesting that officers feared the stigma associated with the need for stress counseling. Officers working in supportive counseling climates had significantly less stress, a reduced need for counseling, and a greater willingness to use counseling. Officers who engaged in counseling (at least occasionally) also reported more stress, indicating an awareness of their need for counseling. The authors concluded that police departments should consider requiring mandatory and periodic counseling for all officers, a procedural tactic that camouflages counseling need while concurrently treating the source of officer stress.     

Childhood Sexual Abuse and Intimate Partner Violence among Women in Methadone Treatment: A Direct or Mediated Relationship?

Women in substance use treatment report rates of childhood sexual abuse and intimate partner violence that far exceed those reported by women in the general population. Previous research with nonrandom samples of women in substance use treatment suggests that there is a statistically significant relationship between childhood sexual abuse and intimate partner violence; however, little is known about the mechanisms of risk between these two public health concerns among this population of women. To address this gap in knowledge and to inform intervention strategies, this study examined direct and mediated relationships between childhood sexual abuse and intimate partner violence risk among a random sample of 416 women in methadone treatment. In addition to high rates of childhood sexual abuse (57.9%), intimate partner violence (lifetime prevalence, 89.7%; 6-month prevalence, 78.4%), posttraumatic stress disorder (PTSD, 28.6%), and global psychological distress (19.5%), findings suggest that the relationship between childhood sexual abuse and intimate partner violence is mediated by mental health problems and that women experiencing PTSD or global psychological distress are 2.7 and 2.4 times more likely to experience intimate partner violence than women without such experiences, respectively. Although not a mediator in this relationship, financial independence reduced women's risk of partner violence by two-thirds. The paper includes discussion of social learning and stress and coping theories to explicate the findings and to inform intervention strategies. This study is based, in part, on the first author's dissertation. A previous version of this paper was presented at the Society for Social Work and Research Annual Conference held in January 2005 in New Orleans, Louisiana. The following grants provided funding for this study: R01DA11027 and 3T32MH014623-22S1.     

产前热应激对仔鼠生殖腺GABA能神经元受体发育的影响

12只13d孕龄的母鼠随机被分为2组,每组6只,以探讨产前热应激对新生仔鼠生殖腺GABA能神经元受体发育的影响。试验组(热应激组)孕鼠置于42℃±0.31℃、相对湿度为36.7%±1.42%的热应激箱中至肛温达到41℃;对照组孕鼠置于常温对照箱里。之后放回笼中分笼饲养。在仔鼠出生后第1、3、5、7天分别剖取睾丸和卵巢进行Zamboni’s固定,常规石蜡切片及SABC免疫组织化学染色,在光学显微镜下用MiPrd软件检测各组织区域GABA受体免疫细胞阳性率和阳性灰度。结果显示,热应激组的GABAA受体免疫细胞阳性率与对照组无显著差异,但在新生1d的生殖腺区阳性灰度极显著增加;热应激组GABAB受体免疫细胞阳性率只在7d睾丸和5d卵巢显著增加,但其阳性灰度除7d卵巢外均显著增加。结果表明,产前热应激可能通过代偿机制显著增加仔鼠生殖腺GABA受体在细胞膜的密度,从而增强抑制性神经递质在发育中的作用,进一步阻碍新生仔鼠生殖腺的正常发育。