Rapid postmortem changes of rat striatum dopamine, serotonin, and their metabolites as monitored by brain microdialysis

Brain microdialysis was used to monitor changes in extracelluar dopamine (DA), serotonin (5-HT), and their metabolite levels in the rat striatum at death by cervical dislocation. Maximum respective 450-fold and 150-fold increases in the extracelluar output of DA and 5-HT were observed within the first 30 min of death. DA and 5-HT outputs remained elevated over the following 2 h at levels about 100-fold and 50-fold above pre-death values, respectively. In contrast with monoamine outputs, the outputs of the DA metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), and the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA), rapidly decreased by 10% and 20%, respectively 1 h after death. 5-Hydroxytryptophol (5-HTOL) gradually decreased after death. Before death both the extracellular DOPAC/DA and 5-HIAA/5-HT ratios were about 400; after death these ratios dropped to 0.56 and 4.0, respectively at 30 min. These observations suggested that regulation of neurotransmitter releases through the neuronal membrane and metabolisms in the rat striatum were seriously disrupted at death. This finding may be helpful in the determination of death in the field of forensic medicine.     

Trading and trade-offs: Women's livelihoods in Gorno-Badakhshan,Tajikistan

This paper is based on a small micro-level study carried out to assess the impact of recent socio-economic changes in Tajikistan on the livelihoods and well-being of women in Gorno-Badakhshan. It examines the recent involvement of women in trading and informal economic activity with a focus on the trade-offs that women have faced as a result. It argues that the shift towards a market economy in a depressed economic environment has resulted in increasing socio-economic differentiation, insecure livelihoods, and declining social capital. Women's involvement in trading, along with the withdrawal of the state from basic social services, has increased women's workload. Women's participation in the political sphere is declining from an already low base. Increasing material poverty and multiple roles and responsibilities have made it difficult for women to take up opportunities for public participation, even at a local level. The article concludes that there are structural barriers to reducing poverty in Gorno-Badakhshan and raises questions about the possibilities for disadvantaged groups and regions to benefit from a strongly market-based development paradigm.     

Linking past and future: cross-border development and quality of life in the Badakhshans

The 1895 Pamir Convention divided the mountainous region of Badakhshan into separate entities under Russian and British/Afghan influence, leading to a remarkable divergence in the development fortunes of a people once united by kinship. For those in today's Gorno-Badakhshan in Tajikistan, incorporation into the Soviet Union brought investments in education, health, physical infrastructure, and the economy. People living in Afghanistan's Badakhshan Province retained more political freedom but lived remotely within a feudal state where development investment was limited. In recent decades, both regions have experienced conflict that has affected their development. In this article, we use findings from quality of life assessments carried out by the Aga Khan Development Network to illustrate the stark differences between the Badakhshans. We discuss ongoing efforts to implement cross-border development programmes to improve quality of life in both Badakhshans, while noting that their success depends on a stable security environment in the region.     

What are the current preoccupations of economic voting research?

The papers in this volume remind us of the enormous amount of research that has been conducted to date on the economic voting thesis. The sheer volume of findings reported in this theme issue alone is impressive and richly diverse. But what are the core preoccupations that presently fuel this line of investigation? The contributors to this volume include several of the major players in the field. This provides a convenient opportunity to take a snapshot of where the current priorities lie. In all, we see at least two main trajectories, both of which appear to be well on their way to delivering a variety of informative insights.     

One size does not fit all: choosing methods to inform area development

There have always been debates about the methods that should be used to inform and assess development programmes. Experimental methods have become highly advocated as agencies seek rigorous ways to show programme value. However, the benefits and appropriateness of these methods are frequently overstated. We use the Aga Khan Development Network's Quality of Life studies to show that periodic mixed methods approaches are useful to analyse programme contributions and inform area development. We argue that experimental methods should not be idealised, and that research questions and organisational learning should guide pragmatic methodological choices to inform development intervention in real-life contexts.

Une taille unique ne convient pas toujours : comment choisir des méthodes pour éclairer le développement des régions

Il y a toujours eu des débats sur les méthodes qui devraient être employées pour éclairer et évaluer les programmes de développement. Les méthodes expérimentales sont devenues très préconisées dans le cadre de la quête par les organisations de manières rigoureuses de démontrer la valeur de leurs programmes. Cependant, les avantages et le caractère approprié de ces méthodes sont souvent exagérés. Nous utilisons les études sur la qualité de la vie de l'Aga Khan Development Network pour montrer que les approches périodiques basées sur des méthodes mixtes sont utiles pour analyser les contributions des programmes et éclairer le développement des régions. Nous soutenons que les méthodes expérimentales ne devraient pas être idéalisées, et que les questions des recherches et l'apprentissage organisationnel devraient orienter des choix méthodologiques pragmatiques afin d'éclairer les interventions en matière de développement dans les contextes réels.

La unitalla no le queda a todos: seleccionando métodos que informen el desarrollo de áreas

Siempre han existido debates en torno a los métodos que deben usarse para fundamentar los programas de desarrollo y valorarlos. A medida que las agencias han buscado métodos rigurosos para demostrar el valor de sus programas, ciertos métodos experimentales han sido altamente promovidos. Sin embargo, los beneficios y lo apropiado de tales métodos a menudo se ha exagerado. En el presente artículo, los autores utilizan los estudios sobre la Calidad de Vida realizados por la Red de Desarrollo Aga Khan, con el fin de mostrar que los enfoques de métodos mixtos aplicados periódicamente resultan útiles para analizar los aportes de los programas y para potenciar el área de desarrollo. Asimismo, sostienen que no deben idealizarse los métodos experimentales y que las inquietudes de investigación y el aprendizaje organizacional deberán guiar las opciones metodológicas pragmáticas orientadas a fundamentar las acciones de desarrollo en la vida cotidiana.

Um único tamanho não serve para todos: Escolhendo métodos para informar a área de desenvolvimento

Tem havido frequentemente debates sobre os métodos que deveriam ser utilizados para informar e avaliar programas de desenvolvimento. Métodos experimentais têm sido altamente defendidos quando as agências buscam formas rigorosas de mostrar o valor do programa. Porém, os benefícios e adequação destes métodos são frequentemente superestimados. Utilizamos os estudos sobre Qualidade de Vida da Aga Khan Development Network para mostrar que abordagens de métodos mistos periódicos são úteis para analisar as contribuições dos programas e informar o desenvolvimento de área. Argumentamos que métodos experimentais não devem ser idealizados e que questões de pesquisa e aprendizado organizacional devem orientar escolhas metodológicas pragmáticas para fornecer informações à intervenção de desenvolvimento em contextos da vida real.     

Behavior of genetic markers in recipients after bone marrow transplantation and problems in forensic medicine

The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.     

Older Siblings as Academic Socialization Agents for Younger Siblings: Developmental Pathways across Adolescence

The role of older siblings in younger siblings’ academic socialization becomes increasingly salient during adolescence. This longitudinal study examines the developmental mechanisms through which older siblings shape younger siblings’ academic outcomes and whether older siblings’ peer affiliations predict younger siblings’ educational aspirations and attainment. Data consisted of responses from 395 target adolescents (M_age?=?12.22 years, 48.9% female; 51.6% African American, 38.5% European American) and their older siblings (M_age?=?14.65 years, 50.1% female) across nine years. The findings showed that older siblings’ affiliation with academically disengaged peers at 7th grade predicted younger siblings’ decreased affiliation with academically engaged peers and increased affiliation with disengaged peers at 9th grade. In addition, younger siblings’ affiliation with academically engaged peers predicted greater educational aspirations at 11th grade, which in turn were related to higher postsecondary educational attainment. The identification of developmental processes through which older siblings were associated with younger siblings’ academic success may aid in creating supportive social environments in which adolescents can thrive.

     

What Makes the USA So Innovative?

The word “innovation” tends to bring to mind the USA, rather than Europe or Japan. In the ICT industry, in particular, revolutionary companies such as Apple, Amazon, Google, and Microsoft have succeeded in bringing about numerous innovations. Because of this, it has become second nature to think of innovation as a US phenomenon. What, then, gives rise to so much innovation in the USA? In this article, the author will first provide an overall view of innovation from the perspectives of economics and of management theory and examine the ways in which innovation has been interpreted and defined. Then, the author will consider the question of why the USA is so innovative as a nation from the three perspectives of its historical background, national character, and systems supporting innovation. It will be demonstrated that one of the characteristics of innovation—discontinuity—is well entrenched in the USA, as is a national character that stresses individualism and a culture that forgives failure. The author will suggest that new innovations will continue to be the driving force of US economic growth into the future.     

Can Countries Establish Sovereignty over the Internet?

While the Internet is now a component of people's everyday lives and is becoming more and more convenient, it has also brought about various problems and adverse effects that could be damaging to human rights, corporate interests, and even national interests. In order to address these problems and adverse effects, countries have recently begun to establish national boundaries over the Internet to control it. This article will consider whether countries are capable of establishing sovereignty over the Internet. To this end, first the scope of national sovereignty in terms of the physical entities that make up Internet services, namely, providers, users, network equipment, and network facilities will be defined. Then the four methods for establishing national sovereignty over the Internet from the perspective of social phenomena will be examined. In addition, in examining whether it is possible for countries to secure the power to levy taxes over the Internet, the article will consider the requirements for countries to establish sovereignty over the Internet. Finally, an explanation and attempt to elucidate a new phenomenon involving the movement of corporate earnings to the cloud will be offered.     

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

AIM:To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS:We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula.The formula was constructed using data from the first 100...