A novel method for cyanide quantification in human whole blood using ion chromatography with amperometric detection and its application to cyanide intoxication cases

Cyanide is a highly toxic agent that has been frequently used for suicide in South Korea. It is also used in various industrial fields, such as metal plating, in which many accidental cyanide intoxications have occurred. To overcome the disadvantages of conventional cyanide analysis methods, a simple and fast method for the analysis of cyanide in whole blood using ion chromatography (IC) with amperometric detection was developed in this study. Whole blood samples were deproteinized, diluted, and analyzed using an IC–amperometric detection system. The limits of detection and quantitation were 0.1 and 0.2 mg/L, respectively. The method showed good linearity in the range of 0.2 to 50 mg/L with R² > 0.99. The intra- and inter-assay precision and accuracy values were <10%. The established method was successfully applied to analyze whole blood samples from three cyanide intoxication cases.     

“Jurisdictional Realization of Law” as Judicium: A Methodological Alternative,Beyond Deductive Application and Finalistic Decision

The proposed reflection intends to present the problem of judicial adjudication as a substantially-axiologically founded autonomous moment on the practical realization of law, and to explore this understanding in confrontation with external exigencies, mostly teleologically determined—hence, beyond strict deductive application, as a (normativistic-positivistic) syllogistic reference of facts to norms, and finalistically determined decision, as an option among possible alternatives to achieve specific aims. The main objective is to enter into a discussion on the methodological meaning of “integrity”, “hard cases” and “right answer”, as presented by Ronald Dworkin, and a critical reflection on the criticism(s) of that approach levelled by Neil MacCormick, so as to confront the relevance of principle and policy arguments, in order to bring about a different methodological approach, an alternative jurisprudentialist conception of adjudication, incorporating a practical-normative constitutive dialectics between legal controversy and legal system, such as that presented by Castanheira Neves. The focus will, then, be the legitimacy of the connection of arguments of principle and consequentialist arguments in adjudication, its selection and its justification, stating, therefore, a specifically assumed judicium, a judicative decision, having the legal system as its horizon of normative reference and of substantial and institutional autonomy.

     

Preparing NATO for the Future – Operating in an Increasingly Contested Environment

The global proliferation of precision-strike systems may be challenging the foundations of Western military-technological supremacy. Relatedly, the development of so-called Anti-Access and Area Denial (A2/AD) capabilities across the globe threatens to complicate Western freedom of military movement and access, and could give way to a more contested military-strategic environment. The twin challenges of precision-strike proliferation and A2/AD strongly impact NATO’s agenda, which revolves around strengthening deterrence and defence in Eastern Europe, and addressing the different threats emanating from the so-called Southern European neighbourhood. In order to address or mitigate such challenges, the Alliance needs to produce operational concepts and capabilities able to deliver deterrence and expeditionary warfare in a maturing precision-strike environment, one characterised by the emergence of A2/AD capabilities.     

Responsible and responsive knowing in medical diagnosis: the medical gaze revisited

The medical gaze has long been privileged over the voice of the patient as the source of medical knowledge, in western societies. The ontology (that is, the very existence) of symptoms invisible to scientific observation will thus tend to be questioned by medical professionals. Yet any gaze, even the medical one, is refracted through the lenses both of social‐cultural stereotypes and of gender, and its seeings are shaped by these refractions. In this article, two family physicians and an epistemologist examine certain “unexplained” disorders, in a conversation informed by a feminist perspective: they bring a feminist point of view to bear on these issues. Medically unexplained disorders, which occur most frequently in women, are disabling conditions for which objectively observable symptoms and/or scientific causal explanations are not available. The approach taken in this article makes some of the assumptions underlying clinical knowledge more clearly visible: the authors' conversation situates diagnostic activity in medicine as a gendered, power‐infused social interaction within a cultural context where the gold standard of medical knowledge is very narrowly set. The participants propose responsible and responsive knowing as alternative strategies for knowing well. As they are presented here, these strategies incorporate an awareness of the inherent uncertainty of medical knowledge, raise questions about those to whom the knower is accountable, acknowledge the patient's experiences, and attend to the potentially oppressive effects of expert knowing.     

An Exploration of Religion and Education in the Life of Constance Maynard,Mistress of Westfield College

This article provides an overview of the motivation for digitising Maynard's writings, evaluates the benefits and challenges of reproducing and publishing archives, and considers the implications of greater digitisation. Maynard's writings reveal that she drew on her evangelical belief system as a means of protection and inspiration, and never overcame the concerns of early educationalists to maintain ‘decorum’ and ‘femininity’ in the management of the college. Published and unpublished sources are considered to review Maynard's decision to enter higher education, the inspiration for a Christian college for women, impact of contemporary arguments opposing education for women on Maynard and Westfield College, and Maynard's reaction to the development of a science faculty in the early twentieth century.     

Analyzing block randomized studies: the example of the Jersey City drug market analysis experiment

Objectives

While block randomized designs have become more common in place-based policing studies, there has been relatively little discussion of the assumptions employed and their implications for statistical analysis. Our paper seeks to illustrate these assumptions, and controversy regarding statistical approaches, in the context of one of the first block randomized studies in criminal justice—the Jersey City Drug Market Analysis Project (DMAP).

Methods

Using DMAP data, we show that there are multiple approaches that can be used in analyzing block randomized designs, and that those approaches will yield differing estimates of statistical significance. We develop outcomes using both models with and without interaction, and utilizing both Type I and Type III sums-of-squares approaches. We also examine the impacts of using randomization inference, an approach for estimating p values not based on approximations using normal distribution theory, to adjust for possible small N biases in estimating standard errors.

Results

The assumptions used for identifying the analytic approach produce a comparatively wide range of p values for the main DMAP program impacts on hot spots. Nonetheless, the overall conclusions drawn from our re-analysis remain consistent with the original analyses, albeit with more caution. Results were similar to the original analyses under different specifications supporting the identification of diffusion of benefits effects to nearby areas.

Conclusions

The major contribution of our article is to clarify statistical modeling in unbalanced block randomized studies. The introduction of blocking adds complexity to the models that are estimated, and care must be taken when including interaction effects in models, whether they are ANOVA models or regression models. Researchers need to recognize this complexity and provide transparent and alternative estimates of study outcomes.

     

Parenting and Centrality: The Role of Life Meaning as a Mediator for Parenting and Language Broker Role Identity

Journal of Youth and Adolescence - Language brokering is a prevalent phenomenon in ethnic minority immigrant populations. Although accruing evidence points to the beneficial impacts of healthy role...