Evaluation of histologic changes of the skin in postmortem period

ABSTRACT: Determination of the time of death is an important consideration in forensic practice. Many methods have been attempted to accurately and systematically determine the postmortem interval (PMI). Histologic examination of the skin or appendages is one of the methods tried by few researchers. However, no attempt had been made to analyze the histologic changes in the skin and appendages simultaneously and to compare them with PMI. We sequentially studied the histologic changes of the skin and appendages in the early PMI. The results of the present study show that the skin undergoes progressive morphological changes in the postmortem period. The epidermis and the dermis appeared normal for 6 hours after death, and after this period, degenerative changes began. By 6 to 9 hours after death, degeneration began in the dermis, and by the end of 18 hours, the dermis began to disintegrate. The sweat glands appeared normal for approximately 3 to 4 hours. For 18 hours after death, the sebaceous glands and hair follicles appeared normal, and after this period, degeneration began.     

Renewal Acute Toxicity of Broad-Spectrum Herbicide,Paraquat Dichloride in Channa punctatus (Bloch)

Abstract

Paraquat dichloride (PD) is a major contaminant in aquatic environment and is a cause of concern to different organisms, especially to fishes, as it causes different changes in behavioral and morphological to aquatic creatures. Hence, the objectives of the study are to examine the acute toxicity, behavioral and morphological alterations in air-breathing teleost fish, Channa punctatus (CP) (Bloch). Renewal acute toxicity was performed to calculate the lethal concentration (LC₅₀) by Finney’s probit analysis to CP by exposure to wide range of PD concentrations (30, 60, 90, 120, 150?mg/L) for 24, 48, 72 and 96?h. The LC₅₀ values determined are 93.36, 82.22, 67.93 and 65.87?mg/L for 24, 48, 72 and 96?h, respectively. Maximum allowable toxicant concentrations (MATC) defined by LC₅₀ value is found to be 0.6587?mg/L. The upper and lower 95 percent confidence limit (Fiducial limit) are in narrow range for 24, 48, 72 and 96?h, respectively, and thus results of the experiments are considered good. Fiducial limit calculated helps us to state that the LC50 falls within the specified limit and helps in constructing of toxicity curve. LC50 value gradually decreases with increase in time. Mortality rate was dose-time dependent and increased with increase in concentration. The behavioral changes provide biologically relevant endpoints in evaluating toxicity testing. Deviation from baseline behavior was noticed. Morphological deformities were also seen. The present study provides a clear indication of the toxicity of PD, and is highly toxic even at low level. Hence, it is recommended that appropriate eco-toxicological risk assessment should be made and indiscriminate use of PD by farmers should be discouraged particularly in areas close to aquatic environment.     

Interest Rates and Investment in East Asia: An Empirical Evaluation of Various Financial Liberalisation Hypotheses

The article attempts to shed light on the appropriate interest rate policy in the process of economic development. To this end, we examine whether higher interest rates lead to higher investment (and growth) in four East Asian countries. We find that the investment rate went up with real interest rates up to 9 per cent in all four countries but started declining at still higher interest rates in two of the countries. Further, a banking crisis occurred in each of the three countries for which the real interest rates exceeded 9 per cent. This evidence rejects the ‘neo-structuralist’ argument. Nor does it support unbridled financial liberalisation. Yet, it provides only limited support to Stiglitz's case for ‘mild financial repression (real interest rates near zero)’ since reducing real interest rates from say, 6 to 3 or 0 per cent would have reduced investment. The optimum policy seems to be closest to McKinnon's ‘restrained financial liberalisation’ policy, that is, liberalisation with a moderate upper limit (about 6 or 7 per cent) on the real interest rates.     

Index and ring finger ratio--a new sex determinant in south Indian population

Identification of human remains is an imperative element of any medicolegal investigation, and a challenging task for forensic experts and physical anthropologists worldwide. Three hundred adult hands (150 males and 150 females) belonging to south Indian population were studied to investigate sexual dimorphism of the index and ring finger ratio. The index and ring finger ratio is derived by dividing the index finger length by ring finger length. The index and ring finger ratio is found to be higher in females. Index and ring finger ratio < or =0.9700 identified 80% of males for both hands, and ratio >0.9700 identified 74% females for the right hand and 78% for the left hand accurately. This study may prove useful to determine the sex of an isolated hand when it is subjected for medicolegal examination.     

Traumatic asphyxial deaths in car crush: Report of 3 autopsy cases

Traumatic asphyxia is a rare syndrome due to compression of thorax, abdomen or both. The diagnosis of traumatic asphyxia is based on typical findings consisting of cervico-facial congestion with swelling, multiple petechial hemorrhages in skin and conjunctiva with a history of traumatic compression. The authors report three cases of traumatic asphyxia in car crash to illustrate few unusual findings along with the typical autopsy findings. All three cases showed the typical findings of traumatic asphyxia. Regarding unusual findings, blisters containing hemorrhagic fluid were observed in two cases over areas subjected to traumatic compression. One case showed the peculiar skin pattern in the form of absent congestion corresponding to the tight-fitting strap of banyan. Subcutaneous emphysema was noted in two cases in presence of intact visceral pleura. These unusual findings could be used as additional markers of traumatic asphyxia in conjunction with characteristic features to support the diagnosis of traumatic asphyxia.     

Fatal Folic Acid Toxicity in Humans

Folic acid is B‐9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23‐year‐old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic acid is rare and has been not reported in the literature, to the best of our knowledge.     

The role of local institutions in sustainable watershed management: lessons from India

The implementation and effective management of watershed-development projects is recognised as a strategy for rural development throughout the developing world. Several government and non-government agencies have launched watershed-development projects to tackle the challenges of soil conservation, improving land productivity, and economic upliftment of the rural poor for efficient use of natural resources. Participatory community-driven institutions of integrated watershed management are considered vital for the sustainability of natural resources. This study focuses on the impact of local institutions on watershed development in India and examines the degree of women's participation in relation to the effective management of natural resources and sustainable development.     

Why the Poor Vote in India: “If I Don’t Vote, I Am Dead to the State”

Our empirical research in India shows the poor and the non-poor report different motivations for voting. The poor say they turn out to vote because it is their right while the non-poor report they vote because they expect material benefits from the state, some kind of access to the state, or because voting is their civic duty. We attribute the different reasons for voting offered by the poor and non-poor to their different relationships with the state. Unlike the non-poor, the poor mostly report the state mistreats or ignores them yet makes every effort on Election Day to ensure they are treated equally. The recognition the state grants to the poor on Election Day leads them to view voting as a valued right, one that gives them a rare chance to associate with those who govern as equals. The evidence in this paper was drawn from 30 focus groups with a total of 445 participants and 150 open-ended interviews conducted across Maharashtra, Tamil Nadu, and Uttar Pradesh and three state and national-level surveys.