Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

Reviews

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Public Co-Financing of Private Sector's Investments: Subsidiarity and Corruption

The literature on corruption makes unclearpredictions on the relations betweensubsidiarity principle, according to whichpublic decisions should be done at thelower level government possible, andcorruption of public officials. In thispaper, we compare two alternative regimes,centralised vs. decentralised, forthe public co-financing of privateprojects. We show that, in the absence ofcorruption, the two regimes give the same results. Borrowing from the Chamberlin's analysis ofmonopolistic competition and from therent-seeking literature, we introducecorruption in the model as a selling costfor the private suppliers. We show that acentralized regime causes higher corruptionlevels because of the higher number ofprivate suppliers of competing projects. Asa result, a central government tends tohave a higher level of public capitalexpenditure than two (equally corruptible)regional governments.     

Casino Politics,Organized Crime and the Post-Colonial State in Macau

Organized crime and politics have been traditionally intertwined in Macau. During the colonial era, the Portuguese administration was characterized by bureaucratic corruption and a cozy relationship with casino capitalists. The colonial state had limited autonomy vis-à-vis the casino capitalists. With the growth of tourism and the associated casino industry in Macau during the 1990s, organized crime groups penetrated various casinos and emerged as a baffling problem. Yet, neither the Portuguese administration nor the casino capitalists had the capability to contain the use of violence by organized crime groups. As Macau approached the end of the Portuguese colonial rule, the People's Republic of China (PRC) decided to intervene in the rapidly deteriorating law and order. The Chinese intervention took the forms of stationing the People's Liberation Army in the Macau Special Administrative Region (SAR), penalizing the triad boss Wan Kuok-kuoi, and supporting the new Edmund Ho Government's attempts at civil service reforms. The SAR Government also liberalized the casino industry by embracing American investment. Due to market competition, the local casino capitalists have been forced to improve the management of casinos and to minimize the infiltration of triads. Unlike the colonial state, the post-colonial state in the Macau SAR has enhanced its relative autonomy vis-à-vis the local casino capitalists, directly or indirectly curbing the detrimental impact of organized crime. The case study of Macau is illustrative of the critical role of state autonomy vis-à-vis casino capitalists, whose previous monopoly over casino management encountered the infiltration of organized crime that grasped the opportunities for maximizing profits in the era of the rapidly expanding casino industry. The Macau example also demonstrates the city-state's use of market competition as a means to improve casino management and to contain the spread of organized crime at least in the short run.     

Between Government and Governance: Opening the Black Box of the Transformation Thesis

The notion of going from government to governance, known as the transformation thesis, as depicted in early Governance Theory has been subjected to substantive critique. This paper explores two different stances of such critique. The first critical stance is represented by Jonathan S. Davies’ 2011 book “Challenging Governance Theory: From networks to hegemony” and entails a radical rejection of the transformation thesis. The second stance offers a more moderate reconfiguration of the transformation thesis and is represented by the recently co-authored work of several prominent governance theorists titled “Interactive Governance: Advancing the paradigm”. While both aspire to set new agendas for governance research, this paper argues that the latter reconfiguration carries a problematic preposition towards overemphasizing the separation between government and governance practices.     

俄罗斯、中国及中亚的权力制衡:融合还是竞争?

近年来,中亚地缘政治结构出现重大变化,传统地缘关系被打破,新的地缘政治格局尚未完全形成.中国、俄罗斯由于自身实力的变化,以及各自在中亚目标存在异同,双方在中亚形成既融合又竞争的态势,而作为中俄在中亚共同的平台――上海合作组织,同样也面临着复杂的发展前景.随着时间的推移,不可确定因素的增加,中亚可能成为更复杂的"舞台".     

Comparative grand corruption and protection pacts among elites: the cases of Ao Man Long in Macao and Hui Si-Yan in Hong Kong

Although Transparency International has consistently ranked the governments of both the Hong Kong Special Administrative Region (HKSAR) and Macao Special Administrative Region (MSAR), both under the sovereignty of the People’s Republic of China (PRC), much higher on the clean governance scale than the PRC itself, the reality is that the two special administrative regions witnessed two prominent cases of political corruption comparable to the mainland corruption. These were the Ao Man Long case in Macao and the Rafael Hui Si-yan scandal in Hong Kong. This paper examines the two cases of political corruption in both Macao and Hong Kong and makes comparisons and contrasts between them. It argues that individual greed contributed to the two cases of high-level bureaucratic (grand) corruption in Macao and Hong Kong, implying that institutional safeguards against corruption, such as the establishment of anti-corruption commissions, and the scrutiny of the mass media, are by no means adequate. In other words, institutional mechanisms against corruption in the HKSAR and MSAR do have loopholes that need to be plugged. Moreover, protection pacts between a minority of government officials and the business elites can be formed because of their close personal connections, strengthening the possibility of grand corruption.     

Introduction to welfare economics

We show that a transfer received by a minority of the population may be sustained by majority voting, however small the minority targeted may be, when the attribution of the transfer is seen as stochastic by voters. We build a simple model wherein voters differ in income and vote over a proportional tax whose proceeds are distributed lump-sum, and each voter has a probability of receiving the transfer that depends on his income. In progressive steps, we present intuitively appealing sufficient conditions on this probability function for the social program to be supported by majority voting. We also develop intuitive conditions for the emergence of the “paradox of redistribution”, whereby more focused targeting reduces the size of the transfer program chosen by the majority. We finally apply our framework to the French social housing program and obtain that our model is consistent with a majority of French voters supporting a positive size for that program.     

New Technologies Stuck in Old Hierarchies: The Diffusion of Geo-Information Technologies in Dutch Public Organizations

Some 25 years after the introduction of the first geo-information technologies in public organizations, strategies to manage their diffusion are still inadequate. This is problematic in light of the new generation of geo-information technologies that has become available and aims to invest in these new information technologies in order to advance e-government. This study questions how strategies for diffusion of geo-information technologies in public planning organizations can be improved. It shows that classic top-down management often enhances informal diffusion activities that deviate from the formal diffusion strategy. A knowledge management approach, in which geo-information specialists and planners participate in the formation of diffusion policies, can enhance the quality of the formal strategy, thereby preventing deviation and informal diffusion activities. The authors recommend that public planning organizations use this knowledge to improve their diffusion strategies for geo-information technologies.