"Legal highs"-Toxicity in the clinical and medico-legal aspect as exemplified by suicide with bk-MBDB administration

The easily available "legal highs", which are products containing psychoactive substances, such as cathinones, piperazines and synthetic cannabinoids, are abused by adolescents in Poland and in the world as alternatives to classic drugs, such as amphetamines or marijuana. The majority of these potentially dangerous substances are still legal and they are associated with a risk of severe poisoning or even death, and provide new challenges in clinical and forensic toxicological practice. Investigations in the field of "designer drugs" may be well illustrated by the case of a suicide of a 21-year old male who ingested a specified dose of a preparation called "Amphi-bi-a" that contains bk-MBDB, chemically 2-methylamino-1-(3,4-methylenedioxyphenyl) butan-1-one, which belongs to the cathinone group, as a synthetic euphoric empathogen and psychoactive stimulant that is chemically similar to MDMA. It is one of more common components of "legal highs" examined in Poland and other countries. The documentation of the case includes a clinical assessment of the patient's health status performed during his almost 4-h hospitalization before death, autopsy and histological examinations supported by toxicological findings revealing bk-MBDB at extremely high concentrations (at 20mg/l in the blood and 33mg/kg in the liver); hence, this body of evidence contributes to knowledge in the field of "designer drugs". Inventions of designers of new psychoactive xenobiotics, which are much in demand, especially in view of the dynamic Internet marketing, which drums up narcobusiness, must be balanced by a national strategy developed by medical, legal and educational circles in the modern civilized world in order to prevent the spreading of the phenomenon.     

COMPETITION IN FREIGHT RAILWAYS: "ABOVE-THE-RAIL" OPERATORS IN CENTRAL EUROPE AND RUSSIA

The railways of Russia and the Central and Eastern Europeancountries are in the process of restructuring. In most cases,the "vertical separation" reform model is being pursued, andreformers are seeking to introduce competition among freighttrain operators through the provision of "open access" to themonopoly infrastructure. This paper shows that, in two countries,Poland and Romania, a good deal of competition has been createdby the entry of new freight operators, many of them either largeshippers integrating upstream or former freight forwarders.However, in other countries, the incumbent freight operatorsretain virtually 100 percent of the market. In particular, Russiahas taken only the very first steps toward creating competitionin this sector, and new freight train operators face significantbarriers to competing with the incumbent.     

What is the prevalence of abuse in the deaf/hard of hearing population?

It is thought that deaf or hard of hearing individuals are at greater risk of abuse than the hearing population. The purpose of this paper is to systematically examine and integrate existing literature to determine the prevalence rates of neglect, emotional, physical and sexual abuse and intimate partner violence (IPV). A set of inclusion and exclusion criteria was determined. Following this a comprehensive search of numerous databases was conducted. Fourteen studies met the inclusion criteria. Eight studies reviewed the prevalence of sexual abuse, seven reviewed physical abuse, five reviewed emotional abuse, four reviewed neglect and six examined IPV. This exceeds 14 as numerous studies examined multiple types of abuse. Quality assessment indicated 12 studies were of ‘moderate’ quality and the remaining two were rated ‘good’ quality. Issues with similar samples, a tendency towards young, educated women within the IPV data, and small samples suggest caution is to be used when interpreting their results. The reliance on written measures and the absence of an interpreter or translation of materials in some studies further complicates the results. All types of abuse were found to be more prevalent within the deaf and hard of hearing population compared to the hearing population.     

Application of the Electrical Network Frequency (ENF) Criterion. A case of a digital recording

One of the new methods of investigating the authenticity of evidential digital audio recordings uses the Electrical Network Frequency (ENF) Criterion. It is based on analysing the signal corresponding to the fundamental frequency of the current in the electrical network, which is present in a recording and comparing it with appropriate, reliable reference. Studies carried out at the Institute of Forensic Research in Cracow were aimed at validating this method, that is, assessing its usefulness in forensic examinations of evidential digital recordings in Poland. These studies enabled us to develop and implement a procedure for using the ENF Criterion method to assess the integrity of digital recordings and to establish when these recordings were made.     

Common EU Minimum Standards for Enhancing Mutual Admissibility of Evidence Gathered in Criminal Matters

The EU, while developing instruments for evidence-gathering in criminal matters, is not making much of an effort to enhance its admissibility. This may lead to situations where, given the differences between legal systems across the EU, evidence collected in one member state will not be admissible in other member states. Due to the fact that the Lisbon Treaty opened the possibility of adopting minimum rules concerning, among other things, the mutual admissibility of evidence, this paper is dedicated to verifying whether it is feasible to achieve various common EU minimum standards for evidence-gathering.     

Postmortem urine immunoassay showing false-positive phencyclidine reactivity in a case of fatal tramadol overdose

This is a report of postmortem false-positive reactivity using an enzyme-multiplied urine phencyclidine (PCP) immunoassay (EMIT II+) due to a single-agent fatal tramadol overdose. An autopsy of a 42-year-old male who died alone at home revealed no identifiable lethal anatomic abnormalities, thus leading to toxicologic analysis. Femoral blood was obtained for drug testing by high-performance liquid chromatography (HPLC) and showed a tramadol level of 14.0 mg/L, 2 orders of magnitude greater than the therapeutic range (0.1 to 0.3 mg/L). Urine was also obtained and EMIT II+ immunoassay revealed positivity for PCP at 88 mAU/min. However, confirmatory testing by HPLC failed to identify PCP in either the urine or serum. To verify the suspicion that this was a false-positive PCP result, stock solutions of tramadol and its major metabolite (O-desmethyltramadol) at concentrations of 100 mg/L in 10% methanol/H2O were compared with a blank solution (10% methanol/H2O) for EMIT II+ PCP reactivity and demonstrated reactivities of 44 mAU/min and 27 mAU/min, respectively. While these individual results were below the cutoff reactivity for a positive EMIT II+ PCP result (ca. 85 mAU/min), they were much more reactive than the blank calibrator (set at 0 mAU/min). Therefore, we conclude that the immunoreactivity of tramadol and its metabolites in aggregate is responsible for the PCP immunoassay interference and false-positive result.