Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances

Novel psychoactive substances (NPS) are synthetic drugs that pose serious public health and safety concerns. A multitude of NPS have been identified in the United States, often implicated in forensic investigations. The most common and effective manner for identifying NPS is by use of mass spectrometry and the true utility lies within nontargeted acquisition techniques. During this study, a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) assay was developed, validated, and implemented for forensic toxicology testing. A SCIEX TripleTOF™ 5600 + with SWATH^® acquisition was used. Resulting data were compared against an extensive library database containing more than 800 compounds. The LC-QTOF-MS assay was applied to the reanalysis of biological sample extracts to discover emergent NPS. More than 3,000 sample extracts were analyzed, and more than 20 emerging NPS were detected for the first time. Among these were isopropyl-U-47700, 3,4-methylenedioxy-U-47700, fluorofuranylfentanyl, N-methyl norfentanyl, 2F-deschloroketamine, 3,4-methylenedioxy-alpha-PHP, eutylone, and N-ethyl hexedrone.     

A Desultory Defense of Democracy: OAS Resolution 1080 and the Inter-American Democratic Charter

This article evaluates the effectiveness of OAS mechanisms for safeguarding democracy through multilateral diplomacy, what some scholars have dubbed the interamerican defense of democracy regime. Drawing on a range of international relations theories, this study derives competing hypotheses about member states' responses to democratic crises in the Americas. It then analyzes all instances in which a collective response—that is, an application of Resolution 1080 or the Inter-American Democratic Charter—was debated in the OAS between 1991 and 2002. Patterns of state behavior suggest that domestic politics, rather than the structural or systemic traits of the interamerican system, best explain foreign policy responses to crises of democracy in the region. The OAS record in confronting such crises is uneven.     

R&D value mapping: A new approach to case study-based evaluation

This study presents an approach to harnessing the power of case studies for research evaluation calledR&D value mapping (RVM). While this method uses case studies in the traditional manner to provide in-depth insights, it also structures case studies through an analytical framework that yields quantitative data and less subjective “lessons learned”. When properly applied, RVM can yield an inventory of outcomes and empirical generalizations regarding the determining variables. A particular advantage of the approach is that it not only provides an indication of the type and amount (though not a single numerical index) of outcome, but also gives insight into the reasons outcomes are achieved. Thus, RVM is useful for policy management strategies seeking to replicate success. The specific steps associated with the RVM method are illustrated through studies that have applied the technique. The authors gratefully acknowledge support from of the Department of Energy, Basic Energy Sciences and previous contracts from Sandia National Laboratories and the New York State Energy Research & Development Authority. A number of persons have made useful comments on the RVM method. We are particularly grateful to David Roessner, Juan Rogers, Gretchen Jordan and Iran Thomas.     

Facing the powers that be

Lobbyists, entrenched forces in congress and self-interested friends will try to stymie Clinton's efforts. A look at four key arenas of combat.     

Reviews

Orlando Figes, A People's Tragedy: The Russian Revolution 1891–1924. London: Jonathan Cape, 1996, xx + 923 pp., £25.00

Hafeez Malik (ed.), The Roles of the United States, Russia and China in the New World Order. Basingstoke: Macmillan, 1997, xvi + 333 pp., £47.50.

Leszek Buszynski, Russian Foreign Policy after the Cold War. Westport and London: Praeger, 1996, xiv + 243 pp., £46.95.

Mette Skak, From Empire to Anarchy: Postcommunist Foreign Policy and International Relations. London: C. Hurst & Company, 1996, x + 340 pp., £35.00 h/b, £14.95 p/b.

Hans von Zon, The Future of Industry in Central and Eastern Europe. Aldershot: Avebury, 1996, x + 164 pp., £35.00.

Bartlomiej Kaminski (ed.), Economic Transition in Russia and the New States of Eurasia. Armonk, New York: M.E. Sharpe, 1996, xviii + 430 pp.

Ben Fowkes, The Disintegration of the Soviet Union: A Study in the Rise and Triumph of Nationalism. Basingstoke: Macmillan, 1997, xii + 273 pp., £40.00

Juan J. Linz & Alfred Stepan, Problems of Democratic Transition and Consolidation. Southern Europe, South America, and Post‐Communist Europe. London: The Johns Hopkins University Press, 1996, xx + 479 pp., £15.50.

David Lane, The Rise and Fall of State Socialism. Cambridge: Polity Press, 1996, 233 pp., £12.95.

Reneo Lukic & Allen Lynch, Europe from the Balkans to the Urals: The Disintegration of Yugoslavia and the Soviet Union. Oxford: Oxford University Press, 1996, xvii + 436 pp.

Thomas Cushman & Stjepan G. Mestrovic (eds), This Time We Knew: Western Responses to Genocide in Bosnia. New York: New York University Press, 1996, ix + 412 pp., $50.00 h/b, $18.95 p/b.

Derek Hall & Darrick Danta (eds), Reconstructing the Balkans. A Geography of the New Southeast Europe. Chichester: John Wiley & Sons, 1996, xx + 260 pp., £45.00.

Ajay Patnaik. Central Asia. Between Modernity and Tradition. New Delhi: Konark Publishers, 1996, viii + 238 pp.

Rudolf L. Tokes, Hungary's Negotiated Revolution: Economic Reform, Social Change and Political Succession, 1957–1990. Cambridge: Cambridge University Press, 1996, xxiii + 544 pp., £19.95.

John D. H. Downing, Internationalizing Media Theory, Transition, Power, Culture, Reflections on Media in Russia, Poland and Hungary 1980–95. London: Sage, 1996, xviii + 269 pp., £45.00 h/b, £13.95 p/b.

Rogers Brubaker, Nationalism Reframed: Nationhood and the National Question in the New Europe. Cambridge: Cambridge University Press, 1996, xi + 202 pp., £35.00 h/b, £12.95 p/b.

Donald P. Steury (ed.), Intentions and Capabilities: Estimates on Soviet Strategic Forces, 1950–1983. Washington DC: Center for the Study of Intelligence, 1996, xxii + 504 pp.

R. W. Davies, Crisis and Progress in the Soviet Economy, 1931–1933. Basingstoke: Macmillan, 1996, xviii + 612 pp., £65.00.

William Chase, Jeffrey Burds, S. V. Praslova, A. K. Sokolov & E. A. Tiurina (eds), Russian Stale Archive of the Economy: A Research Guide: I. Guide to Collections. Moscow: Blagovest, 1994, xx + 679 pp.

V. P. Butt, A. B. Murphy, N. A. Myshov & G. R. Swain (eds), The Russian Civil War. Documents from the Soviet Archives. London: Macmillan, 1996, xvii + 217 pp., £15.99.

Ilya Somin, Stillborn Crusade: The Tragic Failure of Western Intervention in the Russian Civil War, 1918–1920. New Brunswick, NJ: Transaction Publishers, 1996, ix + 236 pp., £21.95, $32.99.

David R. Shearer, Industry, State, and Society in Stalin's Russia, 1926–1934. Ithaca: Cornell University Press, 1996, xiv + 263 pp., £33.50 h/b, £14.95 p/b.

Peter H. Solomon Jr., Soviet Criminal Justice under Stalin. Cambridge: Cambridge University Press, 1997, xvii + 494 pp., £55.00 h/b, £19.95 p/b.

Richard G. Hovannisian, The Republic of Armenia, Volume III, From London to Sèvres, February‐August 1920, xx + 534 pp., and Volume IV, Between Crescent and Sickle: Partition and Sovietization, xii + 496 pp. Berkeley, University of California Press, 1996. £35.00 each volume.

Ian D. Thatcher & James D. White (eds), Journal of Trotsky Studies. Glasgow: Institute of Russian & East European Studies, 1993–1996, Nos. 1–4, £10.00 (Institutions), £5.00 (Individuals).

Mikhail Baitalsky, Notebooks for the Grandchildren. Recollections of a Trotskyist Who Survived the Stalin Terror, Edited and translated by Marilyn Vogt‐Downey. Atlantic Highlands, New Jersey, 1996, xviii + 447 pp.

Leopoldina Plut‐Pregelj & Carole Rogel, Historical Dictionary of Slovenia. London: The Scarecrow Press, Inc, 1996, xxvii + 345 pp., £63.65.     

B. Reviews: general

A HISTORY OF THE ARAB PEOPLES. By ALBERT HOURANI. London, Faber and Faber, 1991. xviii, 551pp. £25 (hb).

STUDIES IN ARAB HISTORY. Edited by DEREK HOPWOOD. (St.Antony's/Macmillan series.) London, Macmillan, 1990. 189pp. 5 plates and 3 figures.

A HISTORY OF THE SELJUKS: ?BRAHIM KAFESOGLU'S INTERPRETATION AND THE RESULTING CONTROVERSY. Translated and edited By GARY LEISER. Carbondale and Edwardsville, Southern Illinois University Press, 1988. 208pp. Genealogical charts, maps in end covers. $29.95.

THE HISTORY OF THE JEWS IN THE LATIN KINGDOM OF JERUSALEM. By JOSHUA PRAWER. Oxford, Clarendon Press, 1988. xv, 310pp. 5 maps.

ARAB HISTORY AND THE NATION STATE: A STUDY IN MODERN ARAB HISTORIOGRAPHY 1820–1980. By YOUSSEF M. CHOUEIRI. (Exeter Arabic and Islamic Series.) London & New York, Routledge, 1989. xix, 238pp. £35.00

THE END OF EMPIRE IN THE MIDDLE EAST: BRITAIN'S RELINQUISHMENT OF POWER IN HER LAST THREE ARAB DEPENDENCIES. By GLEN BALFOUR‐PAUL. Cambridge, Cambridge University Press, 1991. xxiv, 278pp. £30.00.

THE LETTERS OF T.E. LAWRENCE. Edited by MALCOLM BROWN. Oxford, Oxford University Press, 1991. xi, 564pp. £8.95 (pb).

A PRINCE OF OUR DISORDER: THE LIFE OF T.E. LAWRENCE. By JOHN H. MACK. Oxford, Oxford University Press, 1990. xxvi, 561pp. £9.95 (pb).

UN GRAND RABBIN SEPHARADE EN POLITIQUE 1892–1923. Presented and edited by ESTHER BENBASSA. Mesnil‐sur‐l'Estrée, CNRS, 1990. 263pp.

THE SUPREME MUSLIM COUNCIL: ISLAM UNDER THE BRITISH MANDATE FOR PALESTINE. By URI M. KUPFERSCHMIDT. Leiden, Brill, 1987.

AFTER THE EAGLES LANDED: THE YEMENITES OF ISRAEL. By HERBERT S. LEWIS. Boulder, Westview Press, 1989. xix, 277pp., photographs, glossary.

LAND BEFORE HONOUR: PALESTINIAN WOMEN IN THE OCCUPIED TERRITORIES. By KITTY WARNOCK. (Women in Society: A Feminist List.) London, Macmillan Educational Press, 1990. 199pp.

PEASANT POLITICS IN MODERN EGYPT: THE STRUGGLE AGAINST THE STATE. By NATHAN BROWN. New Haven and London, Yale University Press, 1990. 280pp. 2 maps. £25.00.

SOCIETY AND STATE IN THE GULF AND ARAB PENINSULA. By KHALDOUN HASAN AL‐NAQEEB. London and New York, Routledge, 1990. xvii, 206 pp. £35

THE TURBULENT GULF. By LIESL GRAZ. London, I.B. Tauris, 1990. xi, 312pp. £17.95.

IRAN: THE KHOMEINI REVOLUTION (COUNTRIES IN CRISIS). Edited by MARTIN WRIGHT. Contributors: Nick Danziger, Martin Howe, Baqer Moin, Reza Navabpour, Sir Anthony Parsons, Vahe Petrossian, Amit Roy and Martin Wright. London, Longman, 1989. 128pp. Maps, ills. £6.95.

ISRAEL AND THE PALESTINIANS (COUNTRIES IN CRISIS). Edited by MARTIN WRIGHT. Contributors: Paul Cossali, Roger Hardy, Lawrence Joffe, Noah Lucas, David McDowall, Elfi Pallis, Martin Wright. London, Longman, 1989. 131pp. Maps, ills. £6.95.

MAJOR POLITICAL EVENTS IN IRAN, IRAQ AND THE ARABIAN PENINSULA 1945–1990. By TREVOR MOSTYN. New York & London, Facts on File, 1991. xii, 308pp. £14.95.

WOMEN AT WORK IN THE GULF: A CASE STUDY OF BAHRAIN. By MUNIRA A. FAKHRO. London, Kegan Paul International. 184pp. £45.00

THE POLITICAL ECONOMY OF TURKEY: DEBT, ADJUSTMENT AND SUSTAINABILITY. Edited by TOSUN ARICANLI and DANI RODRIK. Basingstoke, Macmillan, 1990. 275pp. £40 (hb).

AFGHANISTAN: A COUNTRY LAW STUDY. By GHOLAM H. VAFAI. Washington, Library of Congress, 1988. 63pp.

RESISTANCE AND CONTROL IN PAKISTAN. By AKBAR S. AHMED. London & New York, Routledge, 1991. xxiii, 207pp. £12.99 (pb).

MASTERING ARABIC: By JANE WIGHTWICK and MAHMOUD GAAFAR. (Macmillan Master Series.) London, Macmillan, 1990. 370pp.

FROM CODE‐SWITCHING TO BORROWING: A CASE STUDY OF MOROCCAN ARABIC. By JEFFREY HEATH. (Library of Arabic Linguistics, monograph 9.) London, Kegan Paul International, 1990. 328pp.

ARISTOTELIAN LOGIC AND THE ARABIC LANGUAGE IN ALFARABI. By SHUKRI B. ABED. Albany, State University of New York Press, 1991. xxv, 201pp.

OGHUSICA AUS IRAN. By GERHARD DOERFER, WOLFRAM HESCHE, JAMSHID RAVANYAR. Wiesbaden, Harrassowitz, 1990. ix, 146pp. DM 56.‐

ABBASID BELLES LETTRES. Edited by Julia Ashtiany, T.M. Johnstone, J.D. Latham, R.B. Serjeant and G. Rex Smith. (The Cambridge History of Arabic Literature, Vol.II, 1.) Cambridge, Cambridge University Press, 1990. xiii, 517pp.

PENSEE MYTHIQUE, IDEOLOGIE ET ASPIRATIONS SOCIALES DANS UN CONTE DES MILLE ET UNE NUITS. By PATRICE COUSSONNET. (Supplément aux Annales Islamologiques—Cahier no. 13). Cairo, Institut français d'archéologie orientale, 1989. 67 pp. 6 plates.

THE MEADOWS OF GOLD: THE ABBASIDS. By MAS'UDI. Tr. and ed. by PAUL LUNDE and CAROLINE STONE. London and New York, Kegan Paul International, 1989. x, 469pp. £30.00

POESlA ESTRÓFICA (CEJELES Y/O MUWA??AHAT) ATRIBUIDA AL MlSTICO GRANADINO A?‐?u?TARI (SIGLO XIII d.C.).(Preedición, traducción, estudio e índices.) By F. CORRIENTE. Madrid, CSIC, Instituto de Filología, Departamento de Estudios Árabes, 1988. [6], 379pp.

ISLAM, THE STRAIGHT PATH. By JOHN L. ESPOSITO. Oxford University Press, 1988. viii, 230pp. £6.95.

TRADITIONAL ISLAM IN THE MODERN WORLD. By SEYYED HOSSEIN NASR. London, KPI, 1987. x, 335pp.

IN A CALIPH'S KITCHEN: MEDIAEVAL ARABIC COOKING FOR THE MODERN GOURMET. By DAVID WAINES. London, Riad el‐Rayyes Books, 1989. 119pp. 44 colour plates. £14.00.