Fatal Intoxication with Methoxetamine

Methoxetamine (MXE) is a new synthetic drug of abuse structurally related to ketamine and phencyclidine. A case of a 29-year-old male with acute toxicity related to the analytically confirmed use of MXE is reported. The man was found dead at his residence. Biological material was analyzed using liquid chromatography–tandem mass spectrometry. The concentration of MXE in urine of the deceased was 85 μg/mL. Despite the vial containing the blood sample being destroyed during transportation and the blood leaking out into the cardboard packaging, the blood level of MXE was estimated. After determination of the cardboard grammage (approx. 400 g/m³) and the mean mass of the blood obtained after drying (0.1785 ± 0.0173 g per 1 mL), the estimated blood concentration of MXE was found to be 5.8 μg/mL. The high concentration of MXE in blood and urine and the circumstances of the case indicate an unintentional, fatal intoxication with this substance.     

Naming the Nation: A Critical Analysis of Names in Polish Political Discourse

This article offers a critical discursive analysis of proper names used in Polish political discourse, focusing on six addresses to the nation made by prominent public figures of the Polish political scene?the president, prime minister, and the primate of the Catholic Church. The names used in the speeches did not function merely as means of referring to places or persons. The speakers used them to construct an ideologically preferred reality. Those used by the president of Poland ''embellished'' the Communist past of the country and showed his political (post-Communist) option as a viable proposal for Poland. The speeches made by the primate of Poland created a politically uncontroversial image of the country, with the head of the Catholic Church positioned as a moral authority. Finally, the visible absence of names in the prime minister's speech represented the etatistic view of Poland.     

The belief in an unjust world: An egotistic delusion

The main hypothesis of Lerner's just world theory says that people are inclined to think that their physical and social environment is just and that individuals generally get what they deserve and deserve what they get. Contrary to Lerner's assumption, however, it is suggested in the article that in some situations, people may perceive the world as unjust because such a belief has a specific ego-defensive compoment for an individual. It is likely, for instance, that the belief in an unjust world, though in itself a legitimate block to success, may be aggrvated in conditions diagnostic for competence and hence can be used as a special form of self-handicapping strategy. This assumption has been tested in a 2 (low vs. high tendency to engate in self-handicapping behaviors) x by 2 (low vs. high opportunity to use the belief in an unjust world as a self-handicapping strategy) experiment. The results of the study fully supported the author's predictions.     

Identification and synthesis of by-products found in 4-methylthioamphetamine (4-MTA) produced by the Leuckart method

The synthesis of the designer drug 4-methylthioamphetamine (4-MTA) has been carried out using the well-known Leuckart reaction in four versions. The treatment of 4-methylthiophenylacetone with formamide, mixture of formamide/formic acid, ammonium formate, and mixture of ammonium formate and formic acid followed by acid hydrolysis brought about the formation of 4-MTA contaminated with a number of impurities. The gas chromatography mass-spectrometry (GC-MS) analysis of the reaction mixtures allowed identification of the most prominent impurities, such as diasteromers of N,N-di-[β-(4-methylthiophenyl)isopropyl]amine, N,N-di-[β-(4-methylthiophenyl)isopropyl]methylamine, N,N-di-[β-(4-methylthiophenyl)isopropyl]formamide, the Schiff bases derived from 4-MTA and 4-methylbenzaldehyde (benzaldimine) and 4-methylthiophenylacetone (ketimine) as well as some heterocycles: 4-methyl-5-(4'-methylthiophenyl)pyrimidine, 4-(4'-methylthiobenzyl)pyrimidine, 2,6-dimethyl-3,5-di-(4'-methylthiophenyl)pyridine, 2,4-dimethyl-3,5-di-(4'-methylthiophenyl)pyridine. The correctness of identification was confirmed by independent synthesis of these compounds. Each synthesized reference compound was characterized by means of MS, (1)H and (13)C NMR, and IR methods. The stereochemistry of (RR/SS) diasteromer of N,N-di-[β-(4-methylthiophenyl)isopropyl]amine was confirmed by a crystallographic method.     

The analytical profile of some 4-methylthioamphetamine (4-MTA) homologues

The 4-methylthioamphetamine (4-MTA) is a sulphur-containing amphetamine-type stimulant (ATS), which appeared on the illicit market in Europe at the end of 90s. For the purpose of this study, several N-alkyl homologues of 4-MTA, including 4-methylthiomethamphetamine (4-MTMA), 4-methylthioethylamphetamine (4-MTEA), 4-methylthiodimethamphetamine (4-MTDMA), 4-methylthiopropylamphetamine (4-MTPA) and 4-methylthiobutylamphetamine (4-MTBA) were synthesized. The homologues were characterized by means of gas chromatography/mass spectrometry (GC–MS), infrared (IR) spectroscopy and the magnetic resonance spectroscopy (¹H and ¹³C NMR). The gas chromatography and mass spectrometry properties of their acetyl, trifluoroacyl (TFA), pentafluoropropionyl (PFP) and heptafluorobutyryl (HFB) derivatives were also investigated and discussed.     

Some pyridine derivatives as "route-specific markers" in 4-methoxyamphetamine (PMA) prepared by the Leuckart Method Studies on the role of the aminating agent in their distribution in the final product

The two previously unknown isomeric aryl-methylpyridines were prepared and analysed. Both 2,6-dimethyl-3,5-(4'-methoxyphenyl)pyridine and 2,4-dimethyl-3,5-di-(4'-methoxyphenyl)pyridine have been identified as a new by-product in the crude 4-methoxyamphetamine (PMA) obtained via the Leuckart method. The synthesis of 2,6-dimethyl-3,5-diphenylpyridine, which is connected to amphetamine chemistry, is also reported. It was also found that different reagents (formamide, formamide/HCOOH, ammonium formate) used in the course of the Leuckart synthesis of PMA significantly affected the impurity content. The presented results point out on the "high-boiling pyridines" as compounds especially useful in the comparative analysis, since their profile seems to be independent on the purification procedure and may be conveyed from the crude reaction mixture even into a carefully purified final product.     

Access to Documents,Accountability and the Rule of Law—Do Private Watchdogs Matter?

: The ECJ has not so far developed a single, consistent approach to cases in which the right to access official documents is exercised by individuals and organisations pursuing their individual cause (private watchdogs). While in some cases the Luxembourg jurisprudence has followed a restrictive approach, supporting interests and secondary law provisions conflicting with transparency, in other it has unconditionally endorsed a supreme character of the access right. This contribution confronts both of the approaches whenever the access right exercised by private watchdogs has clashed with confidentiality stemming from secondary law provisions: from state aid, staff rules, data protection, antitrust and beyond. The article argues that most often the judicial standard restricting the access right interferes with a feedback relationship between transparency, accountability and the rule of law. This relationship, when properly construed and appraised, may form a basis for an arguably more uniform and stable judicial standard.     

‘Telling our Way of Life': Modes of Mediating Social Life in German and Polish Primary-School Textbooks

The events of 1989-1991 in Central and Eastern Europe brought political and economic changes to the post-Communist societies, which required them to redraw the social and psychological maps of their countries and carried with them the promise of partaking in the 'Western way of life'. The introduction of liberalised ideologies, both at the official level and in most of the freed media, also had to be translated into the countries' education systems. New textbooks that would accommodate the new social and political realities had to be written. We are interested in this article in whether and how these new realities are reflected in primary-school teaching materials. For this paper, our analysis will focus on data from two current textbooks that are used in German and Polish primary schools, respectively. We shall be focusing particularly upon those units of the book aimed at defining or describing realities. Taking into account both linguistic and visual modes of representation, we are interested in revealing the 'way of life', the lived ideologies, constructed in these textbooks.     

Identification of common impurities present in the synthetic routes leading to 4-methylthioamphetamine (4-MTA). Part II: Reductive amination and nitropropene route

In this paper the by-products arising during the synthesis of 4-methylthioamphetamine (4-MTA) by LiAlH(4) reduction of 1-(4-methylthiophenyl)-2-nitropropene (nitropropene route) and reductive amination of 4-methylthiophenyl-2-propanone in the presence of NaCNBH(4) are investigated. The identification of 4-methylthio derivatives of N-(β-phenylisopropyl)benzaldimine, 4-methylthio derivative of N-(β-phenylisopropyl)benzyl methyl ketimine, 1-(4-methylthiophenyl)-N-(4-methylthiobenzyl)-2-propanamine, (RS) and (SS/RR)-N,N-di-[β-(4-methylthiophenyl)isopropyl]amine, 4-methylthiobenzyl ether and methylthiobenzoic acid methyl ester as most prominent impurities in crude 4-MTA synthesised by reductive amination of 4-methylthiophenyl-2-propanone, is reported. Methylthio derivatives of 2-methyl-3-phenylaziridine, 2-benzylaziridine, and 4-methylthio derivative of BMK oxime as route-specific markers of nitropropene route leading to 4-MTA, were also characterized. The identity of these compounds was confirmed by their independent synthesis.     

Identification and characterization of 2,5-dimethoxy-4-nitro-β-phenethylamine (2C-N) - A new member of 2C-series of designer drug

The online sale of psychoactive substances, including hallucinogens, is becoming a serious problem in many countries. This paper presents and discusses the mass spectrometric, infrared spectroscopic and nuclear magnetic resonance spectroscopic data of 2,5-dimethoxy-4-nitro-β-phenethylamine (2C-N), which was identified in a powder sample seized by the authorities in 2011 in Poland. The molecular mass of 2C-N (226.0954amu) was confirmed in the LC/ESI-QTOFMS experiment. The molecular ion was also observed in the GC-EI/MS spectrum. A characteristic set of ions for the parent substance was found using both chromatographic methods, and when derivatization with trifuluoroacetic anhydride (TFAA) was applied. Two broad dominant bands at 1520cm(-1) and 1342/1322cm(-1), observed in the FTIR spectrum of 2C-N, originated from the nitro group. NMR spectroscopy helped unequivocal elucidation of the structure. The applied identification procedure proved to be a powerful tool to determine the structure of a new designer drug.