Population genetics of nine short tandem repeat loci: allele frequency distribution in a Brazilian population sample

Gene and genotype frequencies in relation to the D3S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, and D7S820 loci were determined in a sample of 290 unrelated individuals (204 Caucasians and 86 mulattoes) living in the city of S?o Paulo, Brazil. The sex test Amelogenin was also performed in all subjects from our sample, revealing the expected sex in all instances. Allele frequency data obtained from the analysis of these samples were in the usual range of other population groups with similar racial background. In the sample of Caucasian individuals, panmictic proportions were ruled out in relation to TPOX and CSF1PO loci, but only in the latter was the overall frequency of heterozygotes significantly less than expected. In the sample of mulattoes, Hardy-Weinberg proportions were rejected in relation to FGA and CSF1PO loci, but in no instance were the overall numbers of heterozygotes different from the corresponding expected ones under panmixia. Taking into account all this and also the number of tests performed, the degree of genetic heterogeneity of Brazilian populations, and the critical level reached by the significant results (1% < alpha<5%), the departures from panmixia here observed can be considered to be negligible in altering significantly biologic relationship odds calculated under the assumption of random matings.     

Basic education clusters in Cambodia: looking at the future while learning from the past

School clusters have been adopted as an education policy by most Asian countries since the 1960s. In Cambodia, primary schools have been organised in clusters since 1993. Clusters were considered a mechanism for quality improvements of education and a way to facilitate sharing and interaction between schools. Primary school clusters have been partially successful. Today there is a growing interest among Cambodian policymakers for integrating primary schools (Grades 1–6) and lower secondary schools (Grades 7–9). This article provides a policy suggestion by arguing for extending the cluster mechanism to these integrated basic education schools with all grades from 1 to 9.     

Community participation in local governance in Cambodia: learning from the village networks approach

Cambodia has embarked on a process of decentralisation and democratisation, including the establishment of elected Commune Councils in early 2002. Given the lack of a tradition of encouraging civic participation in public affairs, however, there was initially little general awareness of how to engage with these Councils. The authors describe a project supported by the Ministry of Rural Development and the German bilateral agency, GTZ, and undertaken with local non-government organisations, to identify and support active community groups and improve their capacity to interact with the Commune Councils, while at the same time seeking ways for the Commune Councils to support the different groups.     

A case of sudden infant death due to a primary cardiac sarcoma

The case reported herein concerns the unexpected death of a 3-month-old female newborn who suddenly collapsed in her mother's arms and was dead on arrival at the hospital. The clinical histories of the baby and her parents were negative for symptoms or signs of illness, even those of cardiovascular origin. Furthermore, no clinical appearance of a pathologic status was noted by pediatricians after the birth until the last emergency recovery. The autopsy excluded external and internal signs of violence but revealed a large primary cardiac tumor arising from the free wall of the left ventricle, which had totally invaded the heart causing mitral valve deformation. Histological examination showed a low-grade sarcoma that completely infiltrated the myocardial tissue. The pathogenesis of this sudden infant death was postulated as being owing to a fatal ventricular fibrillation combined with a tumor-related restrictive cardiomyopathy obstructing left ventricular filling.     

Y-STRs in forensic medicine: DNA analysis in semen samples of azoospermic individuals

ABSTRACT: The incidence of rape has increased, especially in metropolitan areas, such as the city of São Paulo. In Brazil, studies about it have shown that the majority of this type of crime is committed by the relatives and persons close to the victim. This has made the crime more difficult to be denounced, as only 10% of the cases are reported to competent police authorities. Usually, cytological exams are carried out in sex crime investigations. The difficulty in showing the presence of spermatozoa is frequent, but it does not exclude the presence of male DNA. The absence of spermatozoa in material collected from rape victims can be due to several factors, including the fact that the agressor suffers from azoospermia. This condition can be the result of a successful vasectomy. As the majority of DNA in the ejaculation sample is from spermatozoa, there is much less DNA to be analyzed. This study presents the application of Y‐STRs (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) in DNA analysis of sperm samples from 105 vasectomized men. The study demonstrated a great variation in DNA concentration. DNA extraction and amplification was possible in all sperm samples even in the absence of spermatozoa. The same profile was observed, for each individual, from DNA extracted from blood, pre‐ and postvasectomy semen samples. The use of markers specific for Y chromosome in sex crime cases, especially in the absence of spermatozoa, is very important, mainly because in most situations there is a small quantity of the agressor's DNA in the medium and a large quantity of the victim's DNA.     

Assessing Committee Roles in a Developing Legislature: The Case of the Ukrainian Parliament

The Ukrainian parliament consistently attracts scholarly attention as one of the developing parliaments in the Former Soviet Region that is succeeding with institutionalisation. This study assesses committee roles in the legislative process and discusses factors that are associated with strong or weak roles for committees. We bring evidence from the Ukrainian parliament to test traditionally hypothesised institutional factors in committee studies, such as roles of government and parties. To account for the difference between developed and developing legislatures, we add an attitudinal component to the analysis. The results confirm that traditionally hypothesised factors are important in assessing committee roles. However, important intervening factors such as strength and size of factions and the range of ideologies have to be taken into account to explain institutional dynamics in a developing legislature. In addition, an analysis of attitudes provides a valuable insight into the development of committee roles in a developing legislature.     

War and Democratization: Legality,Legitimacy and Effectiveness

Promotion of democracy in post-war and post-conflict societies became a hot topic during the 1990s. External actors linked their peace-building efforts to the promotion of democracy. Four modes of promotion of democracy by external actors can be distinguished: first, enforcing democratization by enduring post-war occupation (mode 1); second, restoring an elected government by military intervention (mode 2); third, intervening in on-going massacres and civil war with military forces (‘humanitarian intervention’) and thereby curbing the national sovereignty of those countries (mode 3); and fourth, forcing democracy on rogue states by ‘democratic intervention’, in other words, democracy through war (mode 4). In this special issue we consider the legality, legitimacy, and effectiveness of the four modes where the international community of states not only felt impelled to engage in military humanitarian or peace-building missions but also in long-term state- and democracy-building. All cases analysed here suggest that embedding democratization in post-war and post-conflict societies entails a comprehensive agenda of political, social, and economic methods of peace-building. If external actors withdraw before the roots of democracy are deep enough and before democratic institutions are strong enough to stand alone, then the entire endeavour may fail.     

关于生育权和人权的思考

《关于生育权和人权的思考》是一个全社会都很关注的热点。生育权涉及到每个民族、每户家庭、每个公民的切身利益。众所周知,上世纪五十年代,当时的全国人大代表、原北京大学校长、人口经济学家马寅初先生曾提出限制人口数量,提高人口质量的意见,遭到诸多非议。几十年过去了,历史和实践已经证明了他《新人口论》思想的科学性和真理性。上世纪七十年代末,我们将计划生育政策作为国策写进宪法,提倡只生一个好,取得了举世瞩目的成就,少生了4亿人,促进了经济发展、社会进步、综合国力提高和人民生活的改善;同时也带来了诸如人口老龄化迅速成为世界之首、计划生育家庭面临较大风险、维护国家安全、国防安全难度增大等诸多问题。