Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

General systems theory and criminal justice

Criminal justice agencies are organized sequentially — “output” from one agency is “input” to the next — but most scholars argue that criminal justice is not a system in a theoretical sense. In this article, it is argued that general systems theory (GST) reveals important insights into criminal justice structures and functions. Specifically, it is argued that the criminal justice system processes “cases” rather than people, and that the common goal of criminal justice processing is to “close cases so that they stay closed.” It also is argued that processing capacity progressively declines, in that at each system point the subsequent agency cannot input as many cases as the previous agency can output. Each agency therefore experiences “backward pressure” to close cases in order to reduce input to the next agency. Overall, this article highlights that criminal justice agents and agencies are best understood as operating in the context of the larger whole, thus it is concluded that criminal justice is a system in the sense of general systems theory.     

WASHINGTON,DU BOIS AND PLESSY V. FERGUSON

Law and Philosophy -     

The race may be close but my horse is going to win: Wish fulfillment in the 1980 presidential election

Using data from the 1980 U.S. presidential election, we investigate the extent to which voter expectations about candidate electoral success and margin of victory are subject to systematic biases. In particular, we examine the extent to which candidate supporters overestimate their choice's likelihood of success. After finding a rather dramatic bias in the direction of wishful thinking, we review alternative explanations of this phenomenon, including a model based on nonrandom contact networks and one based on preference-related differences in expectations about exogenous variables that could affect the election outcome.     

Reviews

Wing Thye Woo, Stephen Parker & Jeffrey D. Sachs (eds), Economies in Transition: Comparing Asia and Eastern Europe. Cambridge, MA: MIT Press, 1997, xiv + 412 pp., £33.95 h/b, £16.95 p/b.

Guy Standing, Russian Unemployment and Enterprise Restructuring: Reviving Dead Souls. Basingstoke: Macmillan, 1996, xxix + 404 pp., £45.00.

Ellen Mickiewicz, Changing Channels: Television and the Struggle for Power in Russia. New York: Oxford University Press, 1997, xiii + 340 pp., $35.00.

Naum Nim (ed.), Dos'e na tsenzuru, No. 1. Moscow: Fond zashchity glasnosti, 1997, 208 pp.

Taras Kuzio, Ukraine under Kuchma: Political Reform, Economic Transformation and Security Policy in Independent Ukraine. Basingstoke: Macmillan, 1997, xxiii + 281 pp., £50.00.

Mary Buckley (ed.), Post‐Soviet Women: from the Baltic to Central Asia. Cambridge: Cambridge University Press, 1997, xvii + 316 pp., £15.95.

Neil Hood, Robert Kilis & Jan‐Erik Vahlne (eds), Transition in the Baltic States: Micro‐level Studies. Basingstoke: Macmillan, 1997, xv + 299 pp., £50.00.

V. Stanley Vardis & Judith B. Sedaitis, Lithuania: The Rebel Nation. Boulder, CO: Westview Press, 1997, xi + 242 pp., £14.50.

Lonnie R. Johnson, Central Europe. Enemies, Neighbours, Friends. Oxford: Oxford University Press, 1996, xii + 339 pp., £15.99.

Gale Stokes, Three Eras of Political Change in Eastern Europe. Oxford: Oxford University Press, 1997, xvi + 240 pp., £13.99.

Kevin F. F. Quigley, For Democracy's Sake: Foundations and Democracy Assistance in Central Europe. Washington, DC: The Woodrow Wilson Center Press, 1997, xix + 190 pp., £13.00.

James Gow, Triumph of the Lack of Will. International Diplomacy and the Yugoslav War. London: C. Hurst and Co., 1997, 343 pp., £14.95.

Robert Chenciner, Daghestan: Tradition and Survival. Richmond: Curzon, 1997, xi + 307 pp., £25.00

William C. Wohlforth (ed.), Witnesses to the End of the Cold War. Baltimore: Johns Hopkins University Press, 1996, xvi + 344 pp., $39.95.

Vladimir N. Brovkin (ed.), The Bolsheviks in Russian Society: The Revolution and the Civil Wars. London: Yale University Press, 1997, vi + 333 pp., £21.00.

Carl Van Dyke, The Soviet Invasion of Finland 1939–40. London: Frank Cass, 1997, xiv + 288 pp., £35.00.

Maurice Friedberg, Literary Translation in Russia: A Cultural History, University Park, Pennsylvania: The Pennsylvania University Press, 1997, viii + 224 pp.