Acute myoglobinuria as a fatal complication of heroin addiction

A fatal case of myoglobinuria complicating heroin addiction is described. Clinically the patient had no overt symptoms of rhabdomyolysis. Pathologists should be alerted to this rare complication in heroin addicts who die of no apparent cause. The antimyoglobin immunoperoxidase technique is useful in confirming the diagnosis.     

Restriction fragment length polymorphism analysis of forensic science casework in the People's Republic of China.

Restriction fragment length polymorphism (RFLP) analysis for the purpose of individualization is now being used in casework in the People's Republic of China. This report describes the use of the multilocus minisatellite probe 33.15 to solve three cases, including two homicides and a rape. In the third case, fetal tissue was analyzed to prove that the alleged rapist was, in fact, the father. In each case, analysis of deoxyribonucleic acid (DNA) resulted in a positive match. The probability of chance association of the DNA fingerprint was calculated as 5.6 x 10(-12), which is similar to the figures reported in the literature.     

September 11: A societal reaction perspective

This article illustratesthe application of the labeling or societalreaction theory regarding the events ofSeptember 11, 2001. It explains thevarious types of labels that societyassigned to ``September 11' and how societalreactions led to governmental and lawenforcement changes. Pertinent opinionpolls were analyzed to indicate the powerof labeling which, in turn, was used todemonstrate how the USA PATRIOT Act waspassed during heightened societalreaction.     

英国的调解制度--近期发展

本文分析了英国近来的一些案例,介绍了英国在采取非诉方法解决争议方面的最新发展,强调了法院在一些案件中的态度.     

Shaped on the Anvil of Mars: Vance and Nettie Palmer and the Great War

In Australia as elsewhere within the belligerent nations of the Great War, dissenting thinkers were marginalised with the mobilisation of militarism. Vance and Nettie Palmer, Australia's most important literary partnership in the interwar period, were initially critical of the war, their response typical of the English radical intelligentsia among whom they were living at the time of its outbreak. Forced back to Australia in 1915, the Palmers had to re-establish themselves in its increasingly turbulent intellectual battlefields. Nettie's earlier anti-war beliefs and cosmopolitanism were undermined while Vance became ever more deeply enmeshed in a discourse concerning the virtues of the “ordinary people”, which encompassed the men of the Australian Imperial Force (AIF). Nevertheless, in their extensive writings about Australia, neither Palmer ever endorsed the legend of the heroic Anzacs. The Great War, however, profoundly shaped their political consciousness and their choice of genre and writing strategies, as it did others of their literary generation. This article will show that the war was a far more important influence on their work than usually acknowledged in Australian literary scholarship, and thereby reveal some of the cultural patterns that shaped their generation of Australian radical writers and intellectuals — particularly in Melbourne, arguably the heartland for the tradition of democratic literary nationalism which the Palmers have been seen to epitomise.     

Quantitative analysis of chlorpromazine by electron spin resonance (ESR) spectroscopy

A simple and sensitive method is described for quantitative analysis of chlorpromazine in blood, serum, urine and tissue homogenate. The chlorpromazine cation radical produced by adding perchloric acid and 2,3-dichloro-5,6-dicyano-p-benzoquinone to the sample can be detected by the ESR method at room temperature. The sensitivity limit is 10 ng, that is, 20 μl of the solution containing 0.5 μg chlorpromazine/ml. The time needed for the measurement is within 10 min. The chlorpromazine radical thus produced is very stable; for example, 95% of the radical was observed after 24 h. The advantage of this method is discussed by comparing with the ordinary spectrophotometry which requires the purification of the sample.     

Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).