Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

Reviews

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North-South Climate Change Negotiations: A Sequential Game with Asymmetric Information

This article determines the conditions under which theSouthern countries should act together, or separately, whilenegotiating with the North about climate change policy andabout the conditions for future Southern engagement. The papermodels the international negotiations with complete and withasymmetric information in a dynamic framework. Results showthat, depending on their characteristics, the differentplayers can obtain benefits delaying the moment of theagreement.     

Casino Politics,Organized Crime and the Post-Colonial State in Macau

Organized crime and politics have been traditionally intertwined in Macau. During the colonial era, the Portuguese administration was characterized by bureaucratic corruption and a cozy relationship with casino capitalists. The colonial state had limited autonomy vis-à-vis the casino capitalists. With the growth of tourism and the associated casino industry in Macau during the 1990s, organized crime groups penetrated various casinos and emerged as a baffling problem. Yet, neither the Portuguese administration nor the casino capitalists had the capability to contain the use of violence by organized crime groups. As Macau approached the end of the Portuguese colonial rule, the People's Republic of China (PRC) decided to intervene in the rapidly deteriorating law and order. The Chinese intervention took the forms of stationing the People's Liberation Army in the Macau Special Administrative Region (SAR), penalizing the triad boss Wan Kuok-kuoi, and supporting the new Edmund Ho Government's attempts at civil service reforms. The SAR Government also liberalized the casino industry by embracing American investment. Due to market competition, the local casino capitalists have been forced to improve the management of casinos and to minimize the infiltration of triads. Unlike the colonial state, the post-colonial state in the Macau SAR has enhanced its relative autonomy vis-à-vis the local casino capitalists, directly or indirectly curbing the detrimental impact of organized crime. The case study of Macau is illustrative of the critical role of state autonomy vis-à-vis casino capitalists, whose previous monopoly over casino management encountered the infiltration of organized crime that grasped the opportunities for maximizing profits in the era of the rapidly expanding casino industry. The Macau example also demonstrates the city-state's use of market competition as a means to improve casino management and to contain the spread of organized crime at least in the short run.     

Contextualising the Notion of Context in Jurilinguistic Studies

International Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique - Context is a notion that is commonly invoked in many linguistic studies, either with very...     

Between Government and Governance: Opening the Black Box of the Transformation Thesis

The notion of going from government to governance, known as the transformation thesis, as depicted in early Governance Theory has been subjected to substantive critique. This paper explores two different stances of such critique. The first critical stance is represented by Jonathan S. Davies’ 2011 book “Challenging Governance Theory: From networks to hegemony” and entails a radical rejection of the transformation thesis. The second stance offers a more moderate reconfiguration of the transformation thesis and is represented by the recently co-authored work of several prominent governance theorists titled “Interactive Governance: Advancing the paradigm”. While both aspire to set new agendas for governance research, this paper argues that the latter reconfiguration carries a problematic preposition towards overemphasizing the separation between government and governance practices.