Polymerase chain reaction (PCR) amplification and human leukocyte antigen (HLA)-DQ alpha oligonucleotide typing on biological evidence samples: casework experience.

The polymerase chain reaction (PCR) method of specific gene amplification was used in casework to synthesize millions of copies of the polymorphic second exon of the human leukocyte antigen (HLA)-DQ alpha (or DQA1) locus from a variety of evidence samples. The HLA-DQ alpha allelic variants in the amplified deoxyribonucleic acid (DNA) were determined in a rapid non-radioactive test by hybridization to sequence-specific oligonucleotide probes in both the dot-blot and reverse dot-blot formats. This genetic typing system has been subjected to blind proficiency testing; the performance of this test in the analysis of experimentally mixed samples was also evaluated. As of August 1990, over 250 cases have been tested and more than 2000 individual evidence (bloodstains, semen stains, individual hairs, bone fragments, and tissue sections) and reference samples have been analyzed. The first 198 of these cases are summarized in this paper; in 65% of the cases with conclusive results a suspect was included, and in 35%, all suspects were excluded. Individual cases as well as some of the general issues relating to forensic science analysis and this genetic typing system are discussed. The high rate of exclusion reported here combined with the ability of PCR to type old evidence samples suggests the relevance of this genetic test for postconviction review; two cases in which the convicted suspect was excluded are discussed.     

Technology-transfer strategies of DOE's conservation programs

This paper examines the process by which R&D results funded by the Office of Conservation and Renewable Energy (CE) of the US Department of Energy (DOE) have generated commercial applications. It looks at examples of technology-transfer procedures and activitees across three of CE's component offices that correspond to the major energy end-use sectors: transportation, buildings, and industry. On the surface, the conservation programs would appear to have little strategic consistency and, therefore, lack the clear leadership many seek in a technology-transfer program. However, as an alternative to strategic consistency, one may tailor the technology-transfer approach of each program to its unique circumstances. This paper presents case studies of such tailoring, in which the diversity of approaches mirrors the complexity of the energy end-use markets and the private-public interests that must be negotiated to successfully commercialize energy-saving innovations. The paper discusses the lessons learned about the conditions requiring adaptive design and the structures and practices that have been proven effective.     

R&D spinoffs: Serendipity vs. a managed process

This paper describes some of the spinoff benefits that can result from R&D projects, and categorizes them in terms of the dimensions of market and technical newness. These dimensions are discussed with reference to two types of spinoffs: 1) alternative market applications, when the results of an R&D project are subsequently applied to a market or use that differs from the originally intended application, and 2) second-generation technologies, when the technology that was the subject of an R&D project is significantly altered or enhanced in unanticipated ways through subsequent R&D. Examples from the Department of Energy's Energy-Related Inventions Program are integrated into the results of literature review to illustrate key concepts, including core technologies, degrees of market and technology newness, technology robustness, and the nature of connections linking spinoffs to prior R&D investments. The paper concludes by discussing spinoffs as a managerial strategy.     

Reviews

Chris Beasley, Sexual Economyths: Conceiving a Feminist Economics (Allen and Unwin) Sydney, 1994.

Jo Bridgeman and Susan Millns (eds), Law and Body Politics—Regulating the Female Body (Dartmouth) Aldershot, 1995.

Rosalyn Diprose, The Bodies of Women: Ethics, Embodiment and Sexual Difference (Routledge) London and New York, 1994.

Moira Gatens, Imaginary Bodies (Routledge) London & New York, 1996.

Elizabeth Grosz, Space, Time and Perversion: The Politics of Bodies (Allen & Unwin) St Leonards, 1995.

Karen Green, The Woman of Reason: Feminism, Humanism and Political Thought (Polity Press) Cambridge, 1995.

Laura E. Donaldson, Decolonizing Feminisms: Race, Gender and Empire‐Building (Routledge) London, 1992.

Maggie Humm, A Reader's Guide to Contemporary Feminist Literary Criticism (Harvester Wheatsheaf) London, 1994.

Maggie Humm, Practising Feminist Criticism: An Introduction (Harvester Wheatsheaf) London, 1995.

Jane Balme and Wendy Beck (eds), Gendered Archaeology: The Second Australian Women in Archaeology Conference, Research Papers in Archaeology and Natural History, No. 26 (ANH Publications, RSPAS, Australian National University) Canberra, 1995.

Patricia Ann Palmieri, In Adamless Eden: The Community of Women Faculty at Wellesley (Yale University Press) New Haven & London, 1995.

Myra Marx Ferree and Patricia Yancey Martin (eds) Feminist Organizations: Harvest Of The New Women's Movement (Temple University Press) Philadelphia, 1995.

Liane V. Davis, Building on Women's Strengths (Haworth Press) New York, 1994.

Dorothy Broom (ed.), Double Bind: Women Affected by Alcohol and Other Drugs (Allen & Unwin) St Leonards, 1994.     

Bonding in a High-Risk and a General Sample of Children:Comparison of Measures of Attachment and Their Relationship to Smoking and Drinking

Bonding in parent, peer, and school domains were compared in a general sample of children and a sample of children of methadone-treated parents. Bivariate comparisons revealed that children of methadone-treated parents had lower SES, and were significantly more likely to smoke cigarettes but not more likely to drink alcohol. Several measures of attachment were significantly different between the two samples across parent, peer, and school domains. Multivariate analyses indicated that the children of methadone-treated parents were more likely to smoke, even after accounting for the effects of demographic and attachment variables. For drinking, sample membership was not found to be significant. Attachment to school decreased the odds of both smoking and drinking in both samples. Peer attachment had no effect on the odds of smoking initiation; however,loyalty to best friend did predict increased odds of drinking initiation.