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The opinion of Advocate General Léger, published on 24November 2005 in C-431/04, opens the way for extending the durationof certain pharmaceutical formulation patents by means of asupplementary protection certificate (SPC). 相似文献
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Helena Teixeira Paula Proena Alain Verstraete Francisco Corte-Real Duarte Nuno Vieira 《Forensic Science International Supplement Series》2005,150(2-3):205
An analytical method using solid-phase extraction (SPE) and high-performance liquid chromatography–mass spectrometry (LC–MS) has been developed and validated for the confirmation of Δ9-tetrahydrocannabinol (THC) in oral fluid samples. Oral fluid was extracted using Bond Elut LRC-Certify solid-phase extraction columns (10 cm3, 300 mg) and elution performed with n-hexane/ethyl acetate. Quantitation made use of the selected ion-recording mode (SIR) using the most abundant characteristic ion [THC + H+], m/z 315.31 and the fragment ion, m/z 193.13 for confirmation, and m/z 318.00 for the protonated internal standard, [d3-THC + H+]. The method proved to be precise for THC, in terms of both intra-day and inter-day analyses, with coefficients of variation less than 10%, and the calculated extraction efficiencies for THC ranged from 76 to 83%. Calibration standards spiked with THC between 2 and 100 ng/mL showed a linear relationship (r2 = 0.999). The method presented was applied to the oral fluid samples taken from the volunteers during the largest music event in Portugal, named Rock in Rio-Lisboa. Oral fluid was collected from 40 persons by expectoration and with Salivette®. In 55% of the samples obtained by expectorating, THC was detected with concentration ranges from 1033 to 6552 ng/mL and in 45% of cases THC was detected at concentrations between 51 and 937 ng/mL. However, using Salivette® collection, 26 of the 40 cases had an undetectable THC. 相似文献
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Peter Atkins Greg Bagley Jim Bartoo Michael Bayer David Beatty David Brown Terry Cook Reggie Fairchild David Foster Bruno Gentil Gordon Goetzmann Michael Green Jim Hamann Rustom Irani Greg Lee Lynn Little Jim Mariani Tom McGuire Doug Merrill Gentaro Murakami Todd Naiven Taisuke Nomura Doug Paul Joe Rodriguez Stephen Silver Howard Suskind Mitsuhiro Tsuchiya Mike Wais Jeff Wright Jonathan Zaremski 《The Journal of Technology Transfer》1992,17(1):58-67
The United States today faces a loss of influence as a world power, a reduction in American independence as a policymaker, and a decline in the standard of living on which Americans have come to depend. History teaches that nations weaker and less productive than the United States can rise to become economic powerhouses and rapidly increase their standards of living. History also teaches that nations failing to recognize their fundamental problems will inevitably decline. American politicians must face what is abundantly clear: the United States is losing ground and must act quickly to reverse its course. This White Paper outlines what must be done. Information about the nation's current status must be analyzed and communicated. Incentives to improve the level of competence in government must be provided and maintained. The emphasis of government policy must be changed to reflect broad economic and technological interests as opposed to special interests. Savings must be encouraged and increased. Infrastructure must be improved Tax laws must be modified to help bring these changes about. Economic and technological issues must be elevated to the importance they require. American thinking must reflect the new realities: that the age of leadership through military power is over, that the requirements for success in the world of the 1990s and beyond require a sound and growing economy that is internationally competitive. The US can accomplish these goals only through foundation-shaking, comprehensive, fundamental changealong the lines we propose herein.This paper is the executive summary (with minor editing modifications) of a white paper that is available from Cornell University's Johnson Graduate School of Management. 相似文献
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The new Finnish law on the status and rights of a patient 总被引:1,自引:0,他引:1
Kokkonen P 《European journal of health law》1994,1(2):127-135
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