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The Limits of Disclosure: What Research Subjects Want to Know about Investigator Financial Interests
Christine Grady R.N. Ph.D. F. A.A.N. Elizabeth Horstmann Jeffrey S. Sussman M.P.H. Sara Chandros Hull Ph.D. 《The Journal of law, medicine & ethics》2006,34(3):592-599
Research participants' views about investigator financial interests were explored. Reactions ranged from concern to acceptance, indifference, and even encouragement. Although most wanted such information, some said it did not matter, was private, or was burdensome, and other factors were more important to research decisions. Very few said it would affect their research decisions, and many assumed that institutions managed potential conflicts of interest. Although disclosure of investigator financial interest information to research participants is often recommended, its usefulness is limited, especially when participation is desired because of illness. 相似文献
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Galen Spencer Hull 《The Journal of Technology Transfer》2000,25(3):319-327
The transfer of the American model of management education to Central and Eastern Europe (CEE) is the subject of this paper. It specifically looks at the impact of a U.S. government-funded program to promote linkages between U.S. business schools and institutions in the CEE region. In 1990, the U.S. Agency for International Development (USAID) was authorized by the Congress to develop a program to assist the countries of the CEE region in their transition from command to market economies. This would consist of training and education in economics and management in nine countries from the Baltic states in the north to Albania in the south. This program, known as the Management Training and Economics Education Project (MTEEP) would include twelve grants amounting to nearly $100 million to eleven U.S. universities that would partner with 14 local institutions of higher education. The paper does not purport to contribute to theoretical literature, but rather to chronicle a trend in technology transfer. The author maintains that over a 10-year period MTEEP has contributed to a significant transfer of educational technology in the form of management education, especially in the establishment of MBA and executive MBA programs as well as management training programs. 相似文献
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Hull MJ Griggs D Knoepp SM Smogorzewska A Nixon A Flood JG 《The American journal of forensic medicine and pathology》2006,27(4):359-362
This is a report of postmortem false-positive reactivity using an enzyme-multiplied urine phencyclidine (PCP) immunoassay (EMIT II+) due to a single-agent fatal tramadol overdose. An autopsy of a 42-year-old male who died alone at home revealed no identifiable lethal anatomic abnormalities, thus leading to toxicologic analysis. Femoral blood was obtained for drug testing by high-performance liquid chromatography (HPLC) and showed a tramadol level of 14.0 mg/L, 2 orders of magnitude greater than the therapeutic range (0.1 to 0.3 mg/L). Urine was also obtained and EMIT II+ immunoassay revealed positivity for PCP at 88 mAU/min. However, confirmatory testing by HPLC failed to identify PCP in either the urine or serum. To verify the suspicion that this was a false-positive PCP result, stock solutions of tramadol and its major metabolite (O-desmethyltramadol) at concentrations of 100 mg/L in 10% methanol/H2O were compared with a blank solution (10% methanol/H2O) for EMIT II+ PCP reactivity and demonstrated reactivities of 44 mAU/min and 27 mAU/min, respectively. While these individual results were below the cutoff reactivity for a positive EMIT II+ PCP result (ca. 85 mAU/min), they were much more reactive than the blank calibrator (set at 0 mAU/min). Therefore, we conclude that the immunoreactivity of tramadol and its metabolites in aggregate is responsible for the PCP immunoassay interference and false-positive result. 相似文献