警务合成实战训练理念探析

警务合成实战课的教学训练使体能、武力使用、射击、查缉等专业技能知识融为一体。警务合成技能训练的实用性、重视训练过程和灵活多变性的训练理念方法有助于提高民警的警务实战能力。     

Caring for the orphan in the Philippines:A Policy-Capacity review

Using synthesis and an integrative approach, the article analyzes laws, policies, and institutions that protect the rights and promote the welfare of orphaned children in the Philippines. The article undertakes an exploratory review of the potential and contemporary impacts of colonialism, imperialism, feudalism, and capitalism on child and youth welfare and describes the conditions and difficulties Filipino children face in the current policy environment. To address these conditions and difficulties, the article offers a synthesis of potential and ongoing policy-capacity solutions in orphan and youth care, such as implementing a strong social supporting structure to grandparents as first caregivers, strengthening a mixed welfare system on orphan care, and legislating a national orphan policy.     

Advances in Offender Profiling: A Systematic Review of the Profiling Literature Published Over the Past Three Decades

Despite the immense popularity of offender profiling as both a topic of fascination for the general public as well as an academic field of study, concerns have been raised about the development of this area of scientific inquiry. The present study provides a preliminary step towards moving the field forward as it reviews the type and quality of studies dealing with offender profiling over the past 31 years. Based on a content analysis of 132 published articles, the review indicates that researchers investigating this phenomenon rarely publish multiple articles, and they are generally reported across many different journals, thereby making knowledge synthesis and knowledge transfer problematic. In addition, the majority of papers published in the area are discussion pieces (e.g., discussing what profiling is, how profiles are constructed, and when profiling is useful), despite the fact that the processes underlying offender profiling are still not well understood. Finally, although peer-reviewed articles exploring this topic have steadily increased, the statistical sophistication of these studies is sorely lacking, with most including no statistics or formal analyses of data. Suggestions for future research and recommendations to streamline efforts in this field are provided based on the results of this review.

A passive approach for effective detection and localization of region-level video forgery with spatio-temporal coherence analysis

In this paper, we present a passive approach for effective detection and localization of region-level forgery from video sequences possibly with camera motion. As most digital image/video capture devices do not have modules for embedding watermark or signature, passive forgery detection which aims to detect the traces of tampering without embedded information has become the major focus of recent research. However, most of current passive approaches either work only for frame-level detection and cannot localize region-level forgery, or suffer from high false detection rates for localization of tampered regions. In this paper, we investigate two common region-level inpainting methods for object removal, temporal copy-and-paste and exemplar-based texture synthesis, and propose a new approach based on spatio-temporal coherence analysis for detection and localization of tampered regions. Our approach can handle camera motion and multiple object removal. Experiments show that our approach outperforms previous approaches, and can effectively detect and localize regions tampered by temporal copy-and-paste and texture synthesis.     

Compounds identified in an illicit generic Xanax tablet are the result of a failed synthesis of alprazolam

Unintended compounds produced by inexperienced clandestine chemists may present a challenge in laboratories tasked with their identification. In March 2020, an anonymously submitted tablet purchased as a generic form of Xanax was analyzed by Erowid's DrugsData.org . The gas chromatography–mass spectrometry (GC–MS) results publicly released online indicated several unidentified compounds due to a lack of database references at that time. Elucidation by our group indicated the presence of several structurally related compounds that were linked to a failed synthesis of alprazolam. For this case study, a published procedure for the synthesis of alprazolam starting with the chloroacetylation of 2-amino-5-chlorobenzophenone was identified as a potential source of this failure. The procedure was reproduced to identify pitfalls of the methodology and examine its possible link to the illicit tablet. Reaction outcomes were analyzed via GC–MS and compared to the tablet submission data. The major compound in this submission, N-(2-benzoyl-4-chlorophenyl)-2-chloroacetamide, along with several related byproducts were successfully reproduced indicating that the tablet contents potentially stem from a failure to synthesize alprazolam.     

Organic impurity profiling of fentanyl samples associated with recent clandestine laboratory methods

Nearly a decade ago, fentanyl reappeared in the United States illicit drug market. In the years since, overdose deaths have continued to rise as well as the amount of fentanyl seized by law enforcement agencies. Research surrounding fentanyl production has been beneficial to regulatory actions and understanding illicit fentanyl production. In 2017, the Drug Enforcement Administration (DEA) began collecting seized fentanyl samples from throughout the United States to track purity, adulteration trends, and synthetic impurity profiles for intelligence purposes. The appearance of a specific organic impurity, phenethyl-4-anilino-N-phenethylpiperidine (phenethyl-4-ANPP) indicates a shift in fentanyl production from the traditional Siegfried and Janssen routes to the Gupta-patent route. Through a collaboration between the DEA and the US Army's Combat Capabilities Development Command Chemical Biological Center (DEVCOM CBC), the synthesis of fentanyl was investigated via six synthetic routes, and the impurity profiles were compared to those of seized samples. The synthetic impurity phenethyl-4-ANPP was reliably observed in the Gupta-patent route published in 2013, and its structure was confirmed through isolation and structure elucidation. Organic impurity profiling results for illicit fentanyl samples seized in late 2021 have indicated yet another change in processing with the appearance of the impurity ethyl-4-anilino-N-phenethylpiperidine (ethyl-4-ANPP). Through altering reagents traditionally used in the Gupta-patent route, the formation of this impurity was determined to occur through a modification of the route as originally described in the Gupta patent.     

Transfer of Triazine‐iron(II) Chromic Complexes Left by Iron Items on Textile Background and Human Skin

Abstract: The research is focused on the detection and transfer of iron traces left by iron items on clothing and human skin. The method is based on the formation of colored complexes between ferrous ions and five synthesized, mostly new triazines. Iron traces originally were left by iron rings on slightly wetted (artificial sweat) cotton fabrics and subsequently transferred to a separate textile substrate. Prior to the use of trazines the contact spots were treated with a new inorganic reducing agent (Sn²⁺) to reduce Fe³⁺ to Fe²⁺. The method is sensitive to detect iron traces on wetted canvas after 10 min contact with iron items. More spectacular results were obtained for traces left on human palm even after very short contact (10 sec). The new iron‐trace‐transfer method eliminated the contact of triazines solutions with human skin. Transmission visible spectra of Fe(II)–triazine complexes were determined.     

Conceptualising,evaluating and communicating uncertainty in forensic science: Identifying commonly used tools through an interdisciplinary configurative review

This study provides a set of tools for conceptualising, evaluating and communicating uncertainty in forensic science. Given that the concept of uncertainty is one that transcends disciplinary boundaries, an interdisciplinary configurative review was carried out incorporating the disciplines of medicine, environmental science and economics, in order to identify common themes which could have valuable applications to the discipline of forensic science. Critical Interpretive Synthesis was used to develop sub-synthetic and synthetic constructs which interpreted and synthesised the underlying evidence and codes. This study provides three toolkits, one each for conceptualisation, evaluation and communication. The study identified an underlying theme concerning the obstacles that would need to be overcome for the effective application of these toolkits and achieving effective conceptualisation, evaluation and communication of uncertainty in forensic science to lay-stakeholders. These toolkits offer a starting point for developing the conversation for achieving greater transparency in the communication of uncertainty. They also have the potential to offer stakeholders enhanced understanding of the nuances and limitations of forensic science evidence and enable more transparent evaluation and scrutiny of the reliability, relevance and probative value of forensic materials in a crime reconstruction.     

The Lumpen and the Popular: Guillermo Cabrera Infante and Julio García Espinosa

This article deals with the post-1959 re-definitions of the concept of 'popular culture' and its relation to the cultural legacy of Havana's nightlife during the 1950s. After the 1959 Revolution, many Euro-Cuban cultural producers saw and represented the cultural expressions of the Afro-Cuban poor in the capital as being central to Cuban 'popular culture'. This article focuses mainly on two Euro-Cuban authors, writer Guillermo Cabrera Infante and filmmaker Julio García Espinosa, whose works during the first years of the 1960s were highly influenced by Havana's nightlife culture. What both authors shared was a view of the nocturnal in Havana as the heterotopical space and time—following Foucault's concept of 'heterotopia' (1998: 175-185)—where the divisions between high and low art in Cuba could be transcended through the encounters of the different cultural traditions then cohabiting in the city.     

Synthesis,structure, in vitro pharmacology,and in vivo activity of trans-3,4-dichloro-N-[[1-(dimethylamino)-4-phenylcyclohexyl]methyl]-benzamide (AP01; 4-phenyl-AH-7921), a novel mixed μ-/κ-opioid

Analogs of non-fentanyl novel synthetic opioids (NSO) with modifications that fall outside of established structure–activity relationships (SARs) for that class of drugs create the question whether or not it should be considered an analog, as defined by 21 U.S.C. §802(32)(A), which is important for its inclusion in the US system of drug scheduling. AH-7921 is a US Schedule I drug and an example of the 1-benzamidomethyl-1-cyclohexyldialkylamine class of NSO. The SARs regarding substitution of the central cyclohexyl ring have not been well characterized in the literature. Therefore, in order to expand the SAR surrounding AH-7921 analogs, trans-3,4-dichloro-N-[[1-(dimethylamino)-4-phenylcyclohexyl]methyl]-benzamide (AP01; 4-phenyl-AH-7921) has been synthesized, analytically characterized, and tested in vitro and in vivo pharmacologically. Using methods described in the original patents for this class of NSO, it was found that the single trans geometric isomer was obtained. The proton nuclear magnetic resonance, mass spectrum, infrared spectrum, and Raman spectrum are reported along with the melting point of the hydrochloride salt. In vitro binding to a battery of 43 central nervous system receptors showed it to be a high-affinity μ-opioid receptor (MOR) and κ-opioid receptor (KOR) ligand (60 nM and 34 nM, respectively). AP01 also had a 4 nM affinity for the serotonin transporter (SERT), which is a higher level of potency at this receptor than most other opioids. In rats, it exhibited antinociception in the acetic acid writhing test. Therefore, the 4-phenyl modification results in an active NSO, but carries with it potential toxicities beyond those expected for currently approved opioid drugs.