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《Forensic Science International: Genetics Supplement Series》2013,4(1):e158-e159
Participation in interlaboratory quality control exercises is one of the main mechanisms currently used for quality assurance and continuous improvement of the trials. The objective of this study was to design, to manage and to evaluate the Colombian Exercise Interlaboratory Quality Control 2012 (CEIQC-2012). The CEIQC-2012 included both practical and theoretical exercises. For practical exercise three samples were provided, two from blood and one from buccal swab, all on FTA cards, participants were requested to process the samples according to the methods and the markers used routinely in their own laboratories. For theoretical section four exercises were sent, and only one was mandatory, the remain have different degrees of difficulty and were optional. In the mandatory exercise, the participants were asked to calculate the partial and total IP of 15 autosomal STRs markers of an alleged father and a son. This exercise involved 28 laboratories from 6 Latin American and Caribbean countries (Brazil, Ecuador, Peru, Panama, Dominican Republic and Colombia), all reported results for the theoretical mandatory and 27 for the practical. Fifty-four STR markers distributed in autosomal, Y and X chromosomes were under consensus. The Proficiency Test conducted through the Colombian National Reference Laboratory has become a useful tool for quality assurance of all Colombian laboratories and some of Latin America and Caribbean that perform DNA testing to establish biological relationships. This exercise is also an excellent opportunity for constant experts training in the region. 相似文献
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《Forensic Science International: Genetics Supplement Series》2013,4(1):e73-e74
In order to increase the information about Indels, we report allele frequencies and statistical parameters of forensic efficiency obtained typing a sample of 114 unrelated healthy individuals living in San Basilio de Palenque – Colombia using a panel of 38 autosomal InDels. No significant deviations from Hardy–Weinberg expectations were found except in the marker rs10629077 (p = 0.0002). The present database will be useful for forensic and paternity purposes for the region studied. Moreover, these additional markers can help forensic laboratories to solve parentage testing as well as to improve the analysis of degraded DNA samples. 相似文献
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《Forensic Science International: Genetics Supplement Series》2013,4(1):e95-e96
Horse genotyping has a wide range of applications such as identification, pedigree verification, parentage test, forensic investigation, population genetics, analysis of diversity, legitimate registration, among others. Following the recommendations of the International Society for Forensic Genetics (ISFG) regarding the use of non-human (animal) DNA in forensic genetic investigations we have developed a multiplex PCR system of 15 autosomal tetra-nucleotide STRs loci to Equus caballus. The system includes the newly described ECAC2, ECAC4, ECAC5, ECAC9, ECAC10, ECAC12, ECAC14, ECAC15, ECAC18, ECAC21, ECAC23, ECAC26, ECAC28, ECAC29 and ECAC30 loci (on chromosomes 2, 4, 5, 9, 10, 12, 14, 15, 18, 21, 23, 26, 28, 29 and 30, respectively). The polymorphism is in average 8 alleles per marker with a maximum of eleven and a minimum of five for the population studied. All markers were in Hardy–Weinberg equilibrium, except ECAC5 (p = 0.0007). The probabilities of paternity (W), exclusion (PE) and cumulative discrimination (PD) for all loci were greater than 0.9999. This work will contribute to the implementation of standardized horse genotyping systems in the forensic community and the horse industry. 相似文献
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《Forensic Science International: Genetics Supplement Series》2013,4(1):e81-e82
This study established allele frequencies and some parameters of forensic interest with 15 autosomal STRs markers in a sample of 172 unrelated individuals from the Department of Cauca – Colombia using the PowerPlex® 16 BIO System (Promega CO) and Qiagen Multiplex PCR (Qiagen) kits. All markers analyzed showed more than 61% of heterozygosity. Penta E and Penta D were the only systems that are not in Hardy Weinberg equilibrium (p < 0.0033) after Bonferroni correction. The probabilities of paternity (W), the power of exclusion (PE) and of discrimination (PD) accumulated for all loci analyzed were 0.9999, 0.9999 and >0.9999, respectively. The parameters of forensic interest have values suitable for routine use in forensic genetics. 相似文献
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《Forensic Science International: Genetics Supplement Series》2013,4(1):e170-e171
This paper presents the genetic characterization of the Embera-Chami Amerindian community of Lapo-Antioquia-Colombia using 38 autosomal Indels. This group of markers showed a high discriminatory power (>99.9999%) and an appropriate power of exclusion (99.40%), allowing the use of these markers in the field of forensic genetics in this population. 相似文献
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Disruptive behavior includes psychopathological and behavioral constructs like aggression, impulsivity, violence, antisociality and psychopathy and is often closely related with diagnostic categories like conduct disorder (CD), attention deficit disorder (ADHD) and antisocial personality disorder (ASP). There is now clear evidence that neurobiological and environmental factors contribute to these phenotypes. A mounting body of evidence also suggests interactive effects of genetic and environmental risks.In this selective review we give an overview over epidemiological aspects of the relation between ADHD and antisocial behavior, including violent aggression and psychopathy. Moreover, we summarize recent findings from molecular genetic studies and particularly discuss pleiotropic effects of a functional polymorphism of the serotonin transporter promoter gene (5HTTLPR) and childhood adversity on ADHD and violent behavior. The reported gene–environment interactions are not only informative for understanding the neurobiological underpinnings of disruptive behavior, but also throw some light on the relation between ADHD and violent behavior from a genetic perspective. The impact of genetic research on forensic psychiatry and future directions of neurobiological research are discussed. 相似文献
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