High performance liquid chromatographic determination of alcohols with reference to body distribution of methanol

A method has been developed on reverse phase high performance liquid chromatography for simultaneous determination of methyl, ethyl and isopropyl alcohols under refractive index detection using pure water as the mobile phase. A good separation has been achieved between these alcohols. Detector response was linear with a detection limit of 5 mg/100 ml. Recovery studies were performed by adding known amounts of methyl and ethyl alcohols to blood, lung and liver within the range 80–90%. The reproducibility of the results was always >90%. The quantitative distribution of methyl alcohol in postmortem body tissues and fluids has been reported in three cases of poisoning.     

Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

大众传媒中歧视问题探究

大众传媒对当前信息传播的重要影响毋庸置疑,由于其宣称的独立性,以及站在政治和商业权力的对立面而受到普遍的赞誉。但在这个貌似公正无私外表的掩饰下,媒体却对现实社会中众多的“歧视”观念的产生和延续有着不可推卸的责任。     

大众传媒对未成年人思想道德建设的影响及对策

随着现代科技的发展,大众传媒的影响深入到社会生活的各个层面,广泛而深刻地影响着人们精神价值的构建,给未成年人的成长环境带来深刻变化。做好未成年人思想道德建设工作必须从新的时代要求出发,重视大众传媒给未成年人成长带来的深刻影响,积极推进未成年人德育工作在理念、机制、方法和内容上的创新,营造有利于未成年人健康成长的良好环境,从而促进未成年人身心健康发展。     

试论构建大众传媒与政策议程的良性互动关系

政策议程的创建对于实现政府决策的科学化与民主化意义巨大 ,而大众传媒则是使社会问题进入政策议程的有效途径之一。随着传媒技术的发展 ,大众传媒在其中扮演的角色会越来越重要。正确认识和把握政策议程与大众传媒两者的互动关系 ,对推进政府公共决策有重要理论价值和重大现实意义。     

绵羊血浆阿维菌素荧光高效液相色谱检测法的建立

建立了一种绵羊血浆中阿维菌素 (AVM )荧光高效液相色谱 (HPLC)检测法。用甲醇提取绵羊血浆中的AVM ,并用ODS C18固相萃取法进行纯化 ,纯化后的AVM经干燥处理后 ,用三氟乙酸酐和N 甲基咪唑对其进行荧光衍生化 ,用荧光HPLC进行检测。本方法的最低检测限为 0 .1ng/mL ,在血浆AVM含量 2 .5～ 5 0 .0ng/mL范围内 ,标准曲线方程为Y =2 72 12x -10 412 (r =0 .9995 ) ,样品的平均回收率为 92 .0 2 %± 6.3 3 %。批内变异系数 1.98%～ 6.2 2 % ,批间变异系数 2 .3 1%～ 8.94%。检测结果显示 ,本方法灵敏度高 ,干扰少 ,重复性好。     

试论毛泽东对中国传统民本思想的超越

毛泽东以马克思主义唯物史观为指导 ,批判地继承和吸收了中国传统民本思想的精华 ,加以改造创新 ,形成了毛泽东群众路线的观点 ,毛泽东在扬弃和超越中延续了中国传统文化的生命力。     

传媒对公共情绪宣导抚慰功能的研究设计

大众传媒作为社会危机的“调节器,”在帮助危机中的民众树立正确的心态、减缓并摆脱焦虑与不安的折磨、唤起他们内心的自信等方面,发挥了它自身的影响力。媒介到底对公共情绪的哪些部分产生了作用,如何运用情绪心理学进行解释,这是我们所要关注的。情绪与个体发展、社会化问题、生活色调、认知活动、健康等方面密切相关。这些关系都是建构新型的大众传播对公共情绪影响理论模型的基础,与人的个体发展密切相关。     

8例利多卡因过敏性休克死的血药浓度分析

目的研究利多卡因过敏性休克死者利多卡因血药浓度及其与死因的关系。方法采用高效液相色谱法(HPLC),分别对使用利多卡因麻醉术中各项指标均正常的8例术中因利多卡因过敏性休克死者的血液和11例顺利完成手术患者的血液进行利多卡因浓度的检测,对比分析两者结果。结果 8例死者利多卡因血药浓度(1．61mg± 0．45mg／L)低于11例正常患者利多卡因血药浓度(2．44mg±0．47mg／L)。结论利多卡因过敏性休克死者血药浓度在正常值范围内,与发生过敏性休克致死无关。     

媒体对定罪量刑活动可能带来负面影响的作用机制

媒体对定罪量刑活动所带来的负面影响,主要是以舆论为中介,其作用机制表现为:媒体传播引发舆论,舆论会带来民愤与民怜两方面效果,民愤与民怜成为影响定罪量刑的两大因素。媒体对定罪量刑活动所带来的负面影响程度受刑事立法、媒体和司法制度等方面因素影响。