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1.
目的观察艾灸对腹泻型肠易激综合征(diarrhea predominant irritable bowel syndrome,IBS-D)模型大鼠海马与结肠组织中核因子κB抑制蛋白(inhibitor of nuclear factor kappa B,IκB)激酶β(IκB kinase beta,IKKβ)、核因子κB抑制蛋白α(NF-kappa-B inhibitor alpha,IKBα)、核因子κB(nuclear factor kappa B,NF-κB)(P65)相对表达水平的影响,探讨艾灸治疗IBS-D的机制。方法将24只健康雄性SD大鼠随机分为空白组、模型组和艾灸组,每组8只。采用慢性束缚联合番泻叶灌胃方法建立IBS-D大鼠模型。艾灸组予以艾灸\"天枢\"\"上巨虚\",每日30min,每日1次,共治疗7d。治疗后,观察大鼠稀便率和直肠扩张所引起腹部回缩反射(abdominal withdrawal reflex,AWR)的最小容量阈值;蛋白质印迹法检测海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平。结果与空白组比较,模型组AWR的最小容量阈值明显下降(P<0.05),稀便率明显升高(P<0.05);海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平明显增加(P<0.05)。与模型组比较,艾灸组AWR的最小容量阈值明显升高(P<0.05),稀便率明显下降(P<0.05);海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平显著降低(P<0.05)。结论艾灸\"天枢\"\"上巨虚\"改善IBS-D大鼠腹泻症状和内脏高敏感性可能与艾灸抑制海马与结肠组织IKKβ/IKBα/NF-κB信号通路有关,且其作用机制可能是通过脑-肠轴途径实现的。 相似文献
2.
杜维明＂新轴心文明＂理念通过对启蒙的反思和多元现代性论域的开拓,揭示出了＂新轴心时代＂文明的发展特点;从文明对话、启蒙反思、儒家人文精神弘扬入手,强调＂新轴心文明＂的历史意义。但该理念关于普世价值的建构、儒家思想的现代转化、文明对话可行性等阐述带有盲目的乐观性,结合现实多元文明互相冲突的困境,杜氏理论还有失偏颇。 相似文献
3.
中国传统社会要求女性以家庭为中心,围绕“父子轴”,努力扮演好贤妻良母的家庭角色,即女性的“三个自我”：女儿、妻子、母亲。近代西力东侵、西学东渐引起中国社会的变革,传统家庭运作模式以及两性社会分工和权力关系出现新的变化。这些刺激了传统女性走出家庭中心,家不再成为女性的场域边界和道德束缚。近代女性走出家庭中心有3种途径。近代以来女性在解放和发展历程中,走出传统家庭相对容易,走出以家庭为中心的传统角色难;摆脱对男性的依附容易,实现社会自立、人格独立难;拓展社会领域容易,维系公私领域中角色的平衡难。 相似文献
4.
目的:探讨电针“百会”、“印堂”、“天枢”穴改善抑郁症消化功能障碍的机制。方法:将30只SD雄性大鼠随机分为正常组、模型组、电针组,每组10只。用放射免疫法测定脑肠肽类激素下丘脑生长抑素(SS)和血清胃泌素(GAS)的含量。结果:慢性应激抑郁型模型大鼠下丘脑SS显著下降和血清GAS显著升高(P<0.01);电针可以升高下丘脑SS和降低血清GAS含量(P<0.05,P<0.01)。结论:调节脑肠肽类激素的释放,可能是电针改善抑郁状态下大鼠消化功能的作用途径之一。 相似文献
5.
目的：探讨脾虚证大鼠甘草甜素（ＧＬ）的药物动力学（ＰＫ）特征,并从胃排空、脑－肠肽两方面探讨其机制。方法：利用血平作用于大鼠１４ｄ,复制实验性脾虚模型（Ｃ组）;用四君子汤（Ａ组）和六味地黄汤（Ｂ组）治疗以反证;用高效液相色谱（ＨＰＬＣ）法测定大鼠体内ＧＬ的血药浓度;用同位素检测其胃液体排空功能;用放射免疫分析法（ＲＩＡ）分析下丘脑和血浆中胃动素（ＭＯＴ）、胆囊收缩素（ＣＣＫ）及生长抑素（ＳＳ）的浓 相似文献
6.
以艾维茵肉鸡为试验动物,研究了垂体-肾上腺轴在传染性腔上囊病病毒(IBDV)强毒株攻击时对免疫系统的调节作用.结果表明,用IBDV强毒株攻击后,试验鸡垂体-肾上腺轴活动加强,血清促肾上腺皮质激素(ACTH)和皮质酮(F)上升,抗IBDV抗体、白细胞介素2(IL-2)和白细胞介素3(IL-3)上升,T淋巴细胞转化率下降.未经IBD疫苗免疫的鸡由于免疫系统遭到IBDV破坏,在IBDV强毒株攻毒后,抗IBDV抗体、IL-2和IL-3的上升幅度均比经IBD疫苗免疫的低.试验鸡血清ACTH和F分别与抗IBDV抗体、IL-2和IL-3呈显著正相关,与T淋巴细胞转化率呈显著负相关,显示机体受病原微生物攻击后垂体-肾上腺轴对免疫系统的调节作用,即增强特异性免疫反应,抑制非特异性免疫细胞的扩增. 相似文献
7.
由于9.11事件的发生,美国的军事外交战略发生了的重大变化,而布什在今年1月29日发表的国情咨文中又公开点名朝鲜,伊拉克,伊朗为邪恶轴心,从此朝鲜半岛的形势开始震荡起来.韩国政府和美国布什政府在朝鲜半岛问题上产生了裂痕.本文分析了金大中阳光政策遇到的困难和朝鲜半岛形势的症结所在以及可预见的前景. 相似文献
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Epigenetic mechanisms are potential mediators of the physiological response to abuse by altering the genetic predisposition of the cellular response to the environment, leading to changes in the regulation of multiple organ systems. This study was established to review the epigenetic mechanisms associated with childhood abuse as well as the long-term determinants that these epigenetic changes may have on future illness. We retrospectively analysed the effect of exposure to adverse childhood experiences (ACEs, specifically those relating to childhood maltreatment) between the ages of 0 and 16 years on the human epigenome, as well as possible clinical associations. After meeting inclusion and exclusion criteria, 36 articles were included in this systematic review. Eight of these studies did not find a relationship between childhood maltreatment and DNA methylation. Of the remaining 28 studies, nine were genome-wide association studies, whereas the rest were candidate gene studies, mainly studying effects on neuroendocrine, serotoninergic and immunoregulatory systems. Meta-analysis of correlation coefficients from candidate gene studies estimated an association of childhood adversity and DNA methylation variation at r = 0.291 (P < 0.0001), and meta-analysis of two epigenome-wide association studies (EWASs) identified 44 differentially methylated CpG sites. In conclusion, childhood maltreatment may mediate epigenetic mechanisms through DNA methylation, thereby affecting physiological responses and conferring a predisposition to an increased risk for psychopathology and forensic repercussions. Similar evidence for somatic illnesses is not yet available.
KEY POINTS
- Adverse childhood experiences are associated with increased mortality partly explained by acquired epigenetic changes
- There is a positive correlation between childhood abuse and DNA methylation at specific gene sites
- The cumulative effect of different types of childhood abuse and neglect may lead to changes in DNA methylation
- Epigenome changes associated with childhood abuse appear to be involved in the development of psychiatric illness in adulthood
- Studying epigenetic changes may have important public health and forensic applications in the future
9.
Nicolene Lottering B.For.Sc. B.App.Sc. Donna M. MacGregor B.Sc. M.Sc. Clair L. Alston B.Math. M.Sc. Ph.D. Debbie Watson B.App.Sc. Laura S. Gregory B.Sc. Ph.D. 《Journal of forensic sciences》2016,61(Z1):S39-S52
Contemporary, population‐specific ossification timings of the cranium are lacking in current literature due to challenges in obtaining large repositories of documented subadult material, forcing Australian practitioners to rely on North American, arguably antiquated reference standards for age estimation. This study assessed the temporal pattern of ossification of the cranium and provides recalibrated probabilistic information for age estimation of modern Australian children. Fusion status of the occipital and frontal bones, atlas, and axis was scored using a modified two‐ to four‐tier system from cranial/cervical DICOM datasets of 585 children aged birth to 10 years. Transition analysis was applied to elucidate maximum‐likelihood estimates between consecutive fusion stages, in conjunction with Bayesian statistics to calculate credible intervals for age estimation. Results demonstrate significant sex differences in skeletal maturation (p < 0.05) and earlier timings in comparison with major literary sources, underscoring the requisite of updated standards for age estimation of modern individuals. 相似文献
10.
胡文政 《中国青年政治学院学报》2004,23(1):77-81
以往教学中对于线段法解线性供求弹性,用图解很繁琐。由于纵轴和横轴法供求弹性的基本思想是用价格变动(P0/△P)和产量变动(△Q/Q0)来解弹性,故借此思想在纵轴法中寻求使Q1=0从而使△Q/Q0=1的条件,在横轴法中寻求在使P0/△P=1的条件,最终取而代之图解可以获得简洁的效果。 相似文献