High performance liquid chromatographic determination of alcohols with reference to body distribution of methanol

A method has been developed on reverse phase high performance liquid chromatography for simultaneous determination of methyl, ethyl and isopropyl alcohols under refractive index detection using pure water as the mobile phase. A good separation has been achieved between these alcohols. Detector response was linear with a detection limit of 5 mg/100 ml. Recovery studies were performed by adding known amounts of methyl and ethyl alcohols to blood, lung and liver within the range 80–90%. The reproducibility of the results was always >90%. The quantitative distribution of methyl alcohol in postmortem body tissues and fluids has been reported in three cases of poisoning.     

Acidic and neutral drugs screen in blood with quantitation using microbore high-performance liquid chromatography–diode array detection and capillary gas chromatography–flame ionization detection

Blood previously acidified with aqueous saturated ammonium chloride solution was extracted with ethyl acetate. The dried extract was subjected to acetonitrile–hexane partition. The acetonitrile portion was analysed for the presence of acidic and neutral drugs by HPLC–DAD (200 mm×2.1 mm I.D. microbore ODS-Hypersil column) and GC–FID (25 m narrow-bore×0.25 mm I.D. HP-5 column with 0.33 μm film thickness). The protocol was found to be suitable for both clinical toxicology (including emergency toxicology) and postmortem toxicology. At least 66 drugs of interest were unequivocally identified by RRTs (HPLC) and UV spectra (DAD) match while another 12 were unequivocally identified by double RRTs match (HPLC and GC). Quantitation was facilitated by incorporating calibration blood standards in each assay batch. The five drugs most commonly encountered in clinical blood specimens (1150 cases) were: paracetamol (47.4% of the cases); chlormezanone (6.6%), theophylline (1.74%), naproxen (1.65%) and mefenamic acid (1.56%). The following drugs were detected in toxicologically significant quantities in postmortem blood specimens (245 cases): phenobarbitone (1.22% of the cases), naproxen (0.82%), chlormezanone (0.82%), theophylline (0.82%), carbamazepine (0.41%) and paracetamol (0.41%).     

当前农民的生活满意度 --一项对安徽阜阳农村的实地调查

通过对安徽省一些农村的实地调查,作者运用社会学和社会心理学的测量方法,探讨了当前农民的生活满意度这一特定的主观感受方面的基本状况.针对目前农村社会发展所遇到的主要问题,文章提出了进一步改善农民生活从而提高其生活满意度的一些政策建议.     

8例利多卡因过敏性休克死的血药浓度分析

目的研究利多卡因过敏性休克死者利多卡因血药浓度及其与死因的关系。方法采用高效液相色谱法(HPLC),分别对使用利多卡因麻醉术中各项指标均正常的8例术中因利多卡因过敏性休克死者的血液和11例顺利完成手术患者的血液进行利多卡因浓度的检测,对比分析两者结果。结果 8例死者利多卡因血药浓度(1．61mg± 0．45mg／L)低于11例正常患者利多卡因血药浓度(2．44mg±0．47mg／L)。结论利多卡因过敏性休克死者血药浓度在正常值范围内,与发生过敏性休克致死无关。     

论非法经营同类营业罪

本文对非法经营同类营业罪规定的国有公司、企业及其中董事、经理的范围和同类营业的内涵等问题进行探讨,以明确本罪犯罪构成。     

政府绩效管理与效率政府建设

本文分析了政府绩效管理的内涵与特点,论述了绩效管理在效率政府建设中的地位与作用,总结了当代政府绩效管理的发展趋势。在借鉴西方政府绩效管理的基本做法,总结我国政府绩效管理取得成就与存在问题的基础上,提出了构建政府绩效管理新模式、建设效率政府的思路与对策。     

论非法经营罪

非法经营罪是97刑法修订后变动最多的一个罪名,值得关注。非法经营罪罪名是否恰当、非法经营罪客体应如何把握、非法经营罪客观方面常见犯罪形态的认定等问题,有必要予以详尽地阐述。     

侦捕诉一体化工作机制的运作原理及实践完善——兼论捕权上提的影响及应对

检察机关在实践中推行的侦捕诉一体化工作机制,是刑事诉讼“互相配合”原则的具体体现.捕权上提改革开展后,给该机制的运作带来诸如办案时间紧张、不捕率上升等问题.检察机关应积极应对捕权上提,整合控诉犯罪资源、采取措施,完善侦捕诉一体化工作机制.     

我国艾滋病行为干预的现实状况与基本评价

艾滋病行为干预是预防、控制艾滋病的重要技术手段,其内容框架主要包括对象、形式、目标、原则、措施等。近年来,我国政府通过采取各种各样的措施,广泛开展行为干预,积极应对艾滋病,取得了明显的成效,但同时也存在不少问题。要充分认识加强艾滋病行为干预工作的重要性和紧迫性,切实认真地执行艾滋病行为干预的政策规定,更加广泛、深入和持久地开展艾滋病的行为干预活动,加大监管力度,分类实施相应的行为干预措施。     

Risks and Realities of Working with Alienated Children

Involvement in custody cases that include accusations of parental alienation—whether as an evaluator, expert witness, lawyer, judge, therapist, provider of a specialized intervention, or researcher—incurs both professional and personal risks. Some risks relate to false negative or false positive identifications of parental alienation that can lead to regulatory agency complaints and public condemnation by the parent who feels wronged by the case outcome. Other risks stem from providing services in an emerging area of practice and working with children who overtly oppose repairing the relationship with their rejected parent. These risks include: unfounded accusations of mistreating children; negatively biased commentary and sensationalist attacks in the media and in social media, professional conferences and journals, and in courtroom testimony; harassment, vilification, and invasion of privacy; threats of violence and public humiliation; shunning and rumor spreading by colleagues; and complaints to regulatory agencies. This article examines circumstances, beliefs, and dynamics that give rise to these risks, suggests precautions to reduce the risk of false accusations against professionals, and offers recommendations for dealing with regulatory agencies. Criticisms that a court or service provider has mistreated a child merit careful scrutiny in the context of the case evidence and empirical data. While some interventions for alienated children raise legitimate concerns, others have been maligned by anecdotal complaints that studies show do not represent the experience of most participants.